Dermal Cell News Volume 9.24 | Jul 17 2023

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    2023-07-17 | DCN 9.24


    Dermal Cell News by STEMCELL Technologies
    Vol. 9.24 – 17 July, 2023
    TOP STORY

    Ultra-Fast and Controlled Capturing, Loading, and Release of Extracellular Vesicles by a Portable Microstructured Electrochemical Fluidic Device

    The device was composed of a fluidic channel confined within antibody-coated microstructured electrodes. As a proof of principle, the device was applied to isolate extracellular vesicles from skin wounds of healthy and diabetic mice.
    [Advanced Materials]

    Full Article
    Explore Antibodies for Epithelial Cell Markers
    PUBLICATIONSRanked by the impact factor of the journal

    Hydrophobic Tetracycline Immobilized in Fibrous Hyaluronan Regulates Adhesive Collagen-Based Hydrogel Stability for Infected Wound Healing

    The hybridized interwoven hydrogel promoted the proliferation and migration of L929 cells and vascularization in vitro.
    [Small]

    Abstract

    Polar Microalgae Extracts Protect Human HaCaT Keratinocytes from Damaging Stimuli and Ameliorate Psoriatic Skin Inflammation in Mice

    The protective activities of polar microalgae extracts on human keratinocyte cell lines against oxidative stress, radiation, and psoriatic cytokine exposure were assessed.
    [Biological Research]

    Full Article

    Integrating Spheroid-on-a-Chip with Tubeless Rocker Platform: A High-Throughput Biological Screening Platform

    Investigators developped a robust gravity-driven technique to culture arrays of cancer cell spheroids and dermal fibroblast spheroids in a high-throughput manner using a rocker platform.
    [Biotechnology Journal]

    Abstract

    Electrotaxis Evokes Directional Separation of Co-Cultured Keratinocytes and Fibroblasts

    Scientists showed the co-cultured electrotaxis of epidermal keratinocytes and dermal fibroblasts with a salt-bridgeless microfluidic approach for the first time.
    [Scientific Reports]

    Full Article

    The Hyaluronan Metabolism in the UV-Irradiated Human Epidermis and the Relevance of In Vitro Epidermal Models

    Using qRT-PCR, confocal microscopy, and LC–MS/MS. tha authors compared the naturally sun-exposed, sun-protected, experimentally repeatedly UVA + UVB-exposed and acutely UVA + UVB irradiated skin of Caucasian women.
    [Experimental Dermatology]

    Abstract

    CD271 Activation Prevents Low to High-Risk Progression of Cutaneous Squamous Cell Carcinoma and Improves Therapy Outcomes

    Spheroids from cutaneous squamous cell carcinoma patients with low-risk or high-risk tumors were established to explore histological features, proliferation, invasion abilities, and molecular pathways modulated in response to CD271 overexpression or activation in vitro.
    [Journal Of Experimental & Clinical Cancer Research]

    Full Article

    MicroRNA-23b Plays a Tumor Suppressive Role in Cutaneous Squamous Cell Carcinoma and Targets Ras-Related Protein RRAS2

    Researchers showed that miR-23b suppressed the expression of a gene network associated with key oncogenic pathways, and that the miR-23b-gene signature was enriched in human cutaneous squamous cell carcinoma.
    [Journal Of Investigative Dermatology]

    Full Article

    Vemurafenib Induces a Noncanonical Senescence-Associated Secretory Phenotype in Melanoma Cells Which Promotes Vemurafenib Resistance

    Investigators found that vemurafenib treatment induced BRAF-mutant but not wild-type melanoma cells into senescence, as manifested by positive β-galactosidase staining, cell cycle arrest, enlarged cellular morphology, and cyclin D1/p-Rb pathway inhibition.
    [Heliyon]

    AbstractFull Article
    Request your free copy of the 'Growing Organoids from Stem Cells' Wallchart
    REVIEWS

    Disease Modification in Inflammatory Skin Disorders: Opportunities and Challenges

    The author assesses the opportunities and challenges in the discovery and development of disease-modifying therapies for chronic inflammatory skin disorders.
    [Nature Reviews Drug Discovery]

    Abstract

    Nanotechnology-Empowered Strategies in Treatment of Skin Cancer

    Scientists summarize the various nanotechnology based combinatorial therapies available for skin cancer with their recent advances, and focus on current status of clinical trials of such therapies.
    [Environmental Research]

    Abstract
    INDUSTRY AND POLICY NEWS

    Melanoma Research Alliance’s RARE Registry for Acral & Mucosal Melanoma Surpasses Industry-Leading 100-Patient Milestone

    The Melanoma Research Alliance began work in 2020 to launch RARE, a direct-to-patient interactive portal, to advance its mission of accelerating treatment options, supporting cutting-edge research and ultimately finding a cure for all types of melanomas.
    [Melanoma Research Alliance]

    Press Release
    FEATURED EVENT

    2023 Barrier Function of Mammalian Skin Seminar GRC

    August 5 – 6, 2023
    Waterville Valley, New Hampshire, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Skin Development, Homeostasis, and Melanoma Initiation

    Duke University – Durham, North Carolina, United States

    Postdoctoral Position – Keloid, Wound Healing, and Fibrosis

    University of Connecticut Health – Farmington, Connecticut, United States

    Postdoctoral Researcher – Multiplex Analysis of Melanoma & Other Solid Tumors

    Karolinska Institutet – Solna, Sweden

    Research Assistant – BC Generations Project

    BC Cancer Center – Vancouver, British Columbia, Canada

    Postdoctoral Position – Skin-Like Polymer Materials

    Sorbonne-Universite – Paris, France

    > See All Jobs

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