 | | Vol. 9.25 – 24 July, 2023 |
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| By engineering mice to re-activate SOX9 in adult embryonic epidermal stem cells, the authors triggered fate switching. Combining epigenetic, proteomic and functional analyses, they interrogated the ensuing chromatin and transcriptional dynamics.
[Nature Cell Biology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| Investigators used two tetrameric ultrashort self-assembling peptide sequences, FFIK and FIIK, to create in vitro 3D models using well-described human dermal fibroblast cells.
[ACS Nano] |
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| Scientists investigated tested the scaffolds with or without mouse embryonic fibroblasts on full-thickness skin wounds on the BALB/c mice to assess their wound healing potential in vivo.
[International Journal Of Biological Macromolecules] |
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| The authors generated genetically modified mice which expressed a Kit-Kit ligand transgene under the control of a doxycycline-inducible promoter to investigate the impact of its overexpression in embryo, young postnatal, and adult skin with intact hair follicles.
[Journal Of Investigative Dermatology] |
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| Researchers assessed how a disruption of normal anatomic skin structure and function influenced the skin damage induced by light from 233 nm far-far-ultraviolet C (UVC) LEDs by inducing superficial skin wounds via mechanical detachment of the stratum corneum in ex vivo human skin.
[Journal Of Photochemistry And Photobiology B-Biology] |
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| p90 ribosomal S6 kinases activity and the functional effects of its inhibition by specific small molecule inhibitors were investigated in established melanoma cell lines and patient-derived short-term cultures from different mitogen-activated protein kinase pathway-hyperactivated genomic subgroups.
[Journal Of Experimental & Clinical Cancer Research] |
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| Using high-throughput RNA sequencing and a linear regression model, researchers identified 1437 coding RNAs and 1177 linear and circular long noncoding that were differentially abundant as a function of age.
[Aging Cell] |
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| Ginsenoside Rg3 was loaded into hydrogel and the effect of Rg3-Gel against UVB‑induced HaCat cells damages was determined by measuring its ability to alleviate UVB‑induced elevation of oxidative stress, pro-inflammatory and apoptotic response.
[Biomedicine & Pharmacotherapy] |
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| Previously, scientists discovered that one of the glucocorticoid receptor target genes, REDD1, was causatively involved in skin atrophy. Here, they investigated its role in glucocorticoid receptor function using HaCaT REDD1 knockout keratinocytes.
[Experimental Dermatology] |
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| The authors summarize the roles of β-blockers in soft tissue wound healing and explore their clinical applications.
[Medicinal Research Reviews] |
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| Verrica Pharmaceuticals Inc. announced FDA approval of YCANTHâ„¢ (cantharidin) topical solution for the treatment of molluscum contagiosum in adult and pediatric patients two years of age and older.
[Verrica Pharmaceuticals Inc.] |
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| August 13 – 18, 2023
Andover, New Hampshire, United States |
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| | TU Dresden – Dresden, Germany |
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| | Duke University – Durham, North Carolina, United States |
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| | University of Connecticut Health – Farmington, Connecticut, United States |
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| | Karolinska Institutet – Solna, Sweden |
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| | Brigham and Women’s Hospital – Boston, Massachusetts, United States |
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