Dermal Cell News Volume 9.26 | Jul 31 2023

    By
    Laurisa Dohm
    -
    0
    16








    2023-07-31 | DCN 9.26


    Dermal Cell News by STEMCELL Technologies
    Vol. 9.26 – 31 July, 2023
    TOP STORY

    Integrated Single-Cell Chromatin and Transcriptomic Analyses of Human Scalp Identify Gene-Regulatory Programs and Critical Cell Types for Hair and Skin Diseases

    Researchers used gene-regulatory maps to prioritize cell types, genes, and causal variants implicated in the pathobiology of androgenetic alopecia, eczema, and other complex traits.
    [Nature Genetics]

    Abstract
    Virtual Conference Exhibition: Pluripotent Stem Cells
    PUBLICATIONSRanked by the impact factor of the journal

    Constructing Epidermal Rete Ridges Using a Composite Hydrogel to Enhance Multiple Signaling Pathways for the Maintenance of Epidermal Stem Cell Niche

    To create an epidermal model with rete ridge microstructures, keratinocytes were cultured on a patterned GelMA-PEGDA hydrogel constructed using molding technology.
    [Acta Biomaterialia]

    AbstractGraphical Abstract

    TRIM71 Reactivation Enhances the Mitotic and Hair Cell–Forming Potential of Cochlear Supporting Cells

    Employing an organoid-based assay, the authors showed that TRIM71 re-expression increased the mitotic and hair cell–forming potential of P5 cochlear supporting cells by facilitating their de-differentiation into progenitor-like cells.
    [EMBO Reports]

    AbstractGraphical Abstract

    Keratinocytes-Specific SOX2 Overexpression Suppressed Pressure Ulcer Formation Following Cutaneous I/R Injury via Enhancement of Amphiregulin Production

    Ulcer formation was significantly suppressed in keratinocytes-specific SOX2-overexpressing mice. SOX2 in skin keratinocytes significantly suppressed the infiltrating inflammatory cells, apoptotic cells, vascular damage, and hypoxic areas in cutaneous ischemia-reperfusion (I/R) injury.
    [Journal Of Investigative Dermatology]

    Abstract

    CD9 Negatively Regulates Collective Electrotaxis of the Epidermal Monolayer by Controlling and Coordinating the Polarization of Leader Cells

    The involvement of tetraspanin-29 (CD9) in electric fields-induced fibrous actin polarization of leader cells, as well as electrotactic migration of the epidermal monolayer, was evaluated by genetic manipulation.
    [Burns & Trauma]

    Full Article

    Microenvironmental Snail1-Induced Immunosuppression Promotes Melanoma Growth

    Transcriptomic analysis of melanoma-associated fibroblasts and analysis of the tumors indicated that stromal Snail1 induced melanoma growth by promoting an immunosuppressive microenvironment and a decrease in anti-tumor immunity.
    [Oncogene]

    Full ArticleGraphical Abstract

    IL-22-Induced Ubiquitin-Specific Protease 15 Promotes Proliferation and Inflammation of Keratinocytes via Stabilization of SCCA2

    Knocking down ubiquitin-specific protease 15 resulted in reduced keratinocyte inflammation, and impaired keratinocyte viability and clonogenicity.
    [Journal Of Investigative Dermatology]

    AbstractGraphical Abstract

    The CD73 Is Induced by TGF-β1 Triggered by Nutrient Deprivation and Highly Expressed in Dedifferentiated Human Melanoma

    Results indicated that serum starvation led to a marked up-regulation of CD73 expression on A375 melanoma cells in a time-dependent manner.
    [Biomedicine & Pharmacotherapy]

    Full ArticleGraphical Abstract

    A Hydrogen Sulfide and Tyrosinase Responsive Dual-Locked Fluorophore for Selective Imaging of Melanoma Cells

    In vitro cell culture studies revealed that a resorufin-based dual-locked fluorescent probe could be activated with endogenous hydrogen sulfide and tyrosinase, and allowed selective imaging of B16-F10 cancer cells under confocal microscopy.
    [Chemical Communications]

    AbstractGraphical Abstract
    How to prioritize and manage your research projects
    REVIEWS

    Polysaccharide Hydrogel Platforms As Suitable Carriers of Liposomes and Extracellular Vesicles for Dermal Applications

    The authors provide a comprehensive overview of state-of-the-art polysaccharide-based hydrogel platforms designed for artificial and natural vesicles with application in drug delivery to the skin.
    [Advanced Drug Delivery Reviews]

    Full ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Senate Panel Approves 2% Bump for NIH Budget in 2024

    Although below the rate of biomedical inflation, it is far more generous than a corresponding House of Representatives bill that would slash NIH’s budget by 6%.
    [Science Insider]

    Editorial
    FEATURED EVENT

    89th Harden Conference – Proteoglycans: Matrix Master Regulators 2023

    September 4 – 7, 2023
    Surrey, England, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Researcher/Project Scientist – Clinical Skin Imaging

    Beckman Laser Institute – Irvine, California, United States

    Research Associate – Epithelial Morphogensis

    TU Dresden – Dresden, Germany

    Postdoctoral Fellow – Skin Development, Homeostasis, and Melanoma Initiation

    Duke University – Durham, North Carolina, United States

    Postdoctoral Position – Keloid, Wound Healing, and Fibrosis

    University of Connecticut Health – Farmington, Connecticut, United States

    Postdoctoral Researcher – Multiplex Analysis of Melanoma & Other Solid Tumors

    Karolinska Institutet – Solna, Sweden

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Dermal Cell News Twitter