Dermal Cell News Volume 9.27 | Aug 14 2023

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    2023-08-14 | DCN 9.27


    Dermal Cell News by STEMCELL Technologies
    Vol. 9.27 – 14 August, 2023
    TOP STORY

    GABA Regulates Electrical Activity and Tumor Initiation in Melanoma

    Using a combination of zebrafish transgenesis coupled with human tissues, scientists demonstrated that GABAergic signaling between keratinocytes and melanocytes promoted melanoma initiation by BRAFV600E.
    [Cancer Discovery]

    AbstractPress Release
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    PUBLICATIONSRanked by the impact factor of the journal

    Hdac1 and Hdac2 Regulate the Quiescent State and Survival of Hair-Follicle Mesenchymal Niche

    Researchers used the hair follicle to show that during growth, the mesenchymal niche of the hair follicle, the dermal papilla (DP), was maintained quiescent by the activity of Hdac1 and Hdac2 in the DP that suppressed the expression of cell-cycle genes.
    [Nature Communications]

    Full Article

    Targeting SERCA2 in Organotypic Epidermis Reveals MEK Inhibition as a Therapeutic Strategy for Darier Disease

    Investigators established a human tissue model of Darier disease to elucidate its pathogenesis and identify potential therapies.
    [JCI Insight]

    AbstractGraphical Abstract

    miR-186-5p Targets TGFβR2 to Inhibit RAW264.7 Cell Migration and Proliferation during Mouse Skin Wound Healing

    Scientists found that miR-186-5p regulated macrophage migration and proliferation to delay wound healing through the TGFβR2/Smad2/p38 molecular axes.
    [Environmental Toxicology]

    Abstract

    Sesamin Attenuates UVA-Induced Keratinocyte Injury via Inhibiting ASK-1-JNK/p38 MAPK Pathways

    Investigators assessed the protective effect of sesamin on ultraviolet A (UVA)-irradiated keratinocytes and determined its potential antiphotoaging effect.
    [Journal Of Cosmetic Dermatology]

    Full Article

    Tranexamic Acid Improves Psoriasis-Like Skin Inflammation: Evidence from In Vivo and In Vitro Studies

    Researchers investigated the effect of noncytotoxic concentrations of tranexamic acid on interleukin-17-induced human keratinocyte cells to determine the status of proliferative psoriatic keratinocytes.
    [Biomedicine & Pharmacotherapy]

    Full Article

    SPI1 Involvement in Malignant Melanoma Pathogenesis by Regulation of HK2 through the AKT1/mTOR Pathway

    The authors investigated the potential regulatory mechanism of Spi-1 proto-oncogene (SPI1) in melanoma. The mRNA and protein levels were measured via qRT–PCR and Western blotting.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    α-Mangostin Suppresses Melanoma Growth, Migration, and Invasion and Potentiates the Anti-Tumor Effect of Chemotherapy

    Researchers investigated α-Mangostin effect on melanoma growth, migration, and invasion and its possible molecular mechanism.
    [International Journal of Medical Sciences]

    Full Article

    3-Deazaneplanocin A, a Histone Methyltransferase Inhibitor, Improved the Chemoresistance Induced under Hypoxia in Melanoma Cells

    Scientists investigated whether epigenetic drugs can improve the chemoresistance induced under hypoxia in cancer cells.
    [Biochemical and Biophysical Research Communications]

    Abstract
    Explore tools and resources for your return to the lab
    REVIEWS

    Melanoma-Derived Mediators Can Foster the Premetastatic Niche: Crossroad to Lymphatic Metastasis

    The authors discuss tumor secretory factors involved in subverting tumor immunity and remodeling lymph nodes and highlight emerging therapeutic strategies.
    [Trends In Immunology]

    Full Article
    INDUSTRY AND POLICY NEWS

    NIH Researchers Say Agency Seeks to Block Unionization Effort

    Early-career researchers who work in labs operated by the US National Institutes of Health (NIH) have hit a roadblock on their way to unionizing.
    [Science Insider]

    Press Release

    Scleroderma Clinical Trial Initiative Snags Sanofi as First Partner to Accelerate Research

    Sanofi will be the inaugural partner for the Scleroderma Research Foundation’s new clinical trial initiative to advance treatments for the rare autoimmune disorder of the skin and organs.
    [Fierce Biotech]

    Press Release
    FEATURED EVENT

    Seventh International Cancer Immunotherapy Conference: Translating Science into Survival

    September 20 – 23, 2023
    Milan, Italy

    > See All Events

    JOB OPPORTUNITIES

    Research Associate – Recombinant Protein

    Creative Biolabs – New York, New York, United States

    Postdoctoral Researcher – Skin Inflammation & Regenerative Disease

    Institut Pasteur – Paris, France

    Principal Investigators – Molecular Cell Science

    Center for Excellence in Molecular Cell Science – Shanghai, China

    Postdoctoral Researcher/Project Scientist – Clinical Skin Imaging

    Beckman Laser Institute – Irvine, California, United States

    Postdoctoral Fellow – Skin Development, Homeostasis, and Melanoma Initiation

    Duke University – Durham, North Carolina, United States

    > See All Jobs

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