Dermal Cell News Volume 9.28 | Aug 21 2023

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    2023-08-21 | DCN 9.28


    Dermal Cell News by STEMCELL Technologies
    Vol. 9.28 – 21 August, 2023
    TOP STORY

    Competing Engagement of β-Arrestin Isoforms Balances IGF1R/p53 Signaling and Controls Melanoma Cell Chemotherapeutic Responsiveness

    Researchers explored whether unbalancing this system downstream of insulin-like growth factor type 1 receptor (IGF1R) could enhance the response of melanoma cells to chemotherapy.
    [Molecular Cancer Research]

    Abstract
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    Human Adipose ECM Alleviates Radiation Induced Skin Fibrosis via Endothelial Cell-Mediated M2 Macrophage Polarization

    Investigators evaluated adipose-derived extracellular matrix (ECM) as a mitigator of radiation-induced skin fibrosis.
    [iScience]

    AbstractGraphical Abstract

    Inhibition of CK2α Accelerates Skin Wound Healing by Promoting Endothelial Cell Proliferation through the Hedgehog Signaling Pathway

    Scientists found that the protein level of casein kinase 2α (CK2α) was increased in the endothelium of mice with type I diabetes induced by streptozotocin injection.
    [FASEB Journal]

    Abstract

    N4BP1 Regulates Keratinocytes Development and Plays Protective Role in Burn- and Adhesive-Related Skin Injury via MMP9

    The authors found that N4BP1 was highly expressed in skin and its expression was further increased upon skin injury.
    [Cellular Signalling]

    Full Article

    Iguratimod Attenuated Fibrosis in Systemic Sclerosis via Targeting Early Growth Response 1 Expression

    Iguratimod was applied in early growth response 1 overexpressed or knockdown human dermal fibroblast, bleomycin pre-treated mice, tight skin 1 mice, and systemic sclerosis skin xenografts.
    [Arthritis Research & Therapy]

    Full Article

    Clinical Significance of the Expression of FOXP3 and TIGIT in Merkel Cell Carcinoma

    Investigators analyzed mRNA expression data of 111 patients with Merkel cell carcinoma (MCC) and performed immunohistochemical analysis to detect the expression of programmed death ligand 1, CD8, FOXP3, TIGIT, and CD155 in 65 cases of MCC.
    [Scientific Reports]

    Full Article

    Topical Application of TOPK Inhibitor OTS514 Suppresses Psoriatic Progression by Inducing Keratinocytes Cell Cycle Arrest and Apoptosis

    Researchers aimed to investigate the expression and role of T-LAK cell-oriented protein kinase (TOPK) in psoriasis, and the role of TOPK inhibitor in psoriasis attenuation.
    [Experimental Dermatology]

    Abstract

    Preferential Killing of Melanoma Cells by a p16-Related Peptide

    Scientists reported the identification of a synthetic, cell-penetrating peptide able to kill human melanoma cells efficiently and selectively, while being less toxic to normal human melanocytes and nontoxic to human fibroblasts.
    [Biology Open]

    Full Article

    Increased Radiosensitivity of Melanoma Cells through Cold Plasma Pretreatment Mediated by ICG

    The photodynamic therapy effect induced by cold plasma irradiation and the radiosensitivity of indocyanine green (ICG) were investigated on DFW, human melanoma cancer cell lines, and HFF cell lines.
    [Journal of Radiation Research]

    Full ArticleGraphical Abstract
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    REVIEWS

    Mesenchymal Stem Cell-Derived Extracellular Vesicles in Skin Wound Healing: Roles, Opportunities and Challenges

    The authors provide a comprehensive overview of the current status of mesenchymal stem cell-derived extracellular vesicle-based therapies in skin wound healing, application potential, and associated drawbacks.
    [Military Medical Research]

    Full Article
    INDUSTRY AND POLICY NEWS

    BriaCell Awarded National Cancer Institute Grant to Advance Its Bria-Ots Immunotherapy for Cancer

    BriaCell Therapeutics Corp. announced that the National Cancer Institute has awarded the Company a research grant to advance its platform of personalized off-the-shelf immunotherapies for cancer.
    [BrioCell Therapeutics, Corp.]

    Press Release
    FEATURED EVENT

    5th TIL Therapies Summit

    October 2 – 4, 2023
    Boston, Massachusetts, United States

    > See All Events

    JOB OPPORTUNITIES

    Molecular Biologist – Skin Cancer

    Heidelberg, Germany – Helmholtz Association of German Research Centres

    Postdoctoral Fellow – Anti-Tumor Immunity and Melanoma Biology

    University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    Research Associate – Recombinant Protein

    Creative Biolabs – New York, New York, United States

    Postdoctoral Researcher – Skin Inflammation & Regenerative Disease

    Institut Pasteur – Paris, France

    Principal Investigators – Molecular Cell Science

    Center for Excellence in Molecular Cell Science – Shanghai, China

    > See All Jobs

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