Dermal Cell News Volume 9.31 | Sep 18 2023

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    2023-09-18 | DCN 9.31


    Dermal Cell News by STEMCELL Technologies
    Vol. 9.31 – 18 September, 2023
    TOP STORY

    Sustained Pigmentation Causes DNA Damage and Invokes Translesion Polymerase Polκ for Repair in Melanocytes

    Researchers systematically investigated the effect of sustained elevation of melanogenesis and mapped the consequent cellular repair response of melanocytes.
    [Nucleic Acids Research]

    Full ArticleGraphical Abstract
    Learn how to be a great STEM mentor to new lab members
    PUBLICATIONSRanked by the impact factor of the journal

    VDR Is an Essential Regulator of Hair Follicle Regression through the Progression of Cell Death

    Scientists showed that, in vitamin D receptor (Vdr)-knockout mice, the hair cycle was halted during the catagen stage, preceding alopecia.
    [Life Science Alliance]

    Full Article

    Induced Differentiation of Primordial Germ Cell Like Cells from SOX9+ Porcine Skin Derived Stem Cells

    SOX9+ skin derived stem cells (SOX9+ SDSCs) were isolated from fetal porcine skin and a high-purity SOX9+ SDSCs population was obtained.
    [Theriogenology]

    AbstractGraphical Abstract

    Effects of Schumann Resonance on the Proliferation and Migration of Normal Human Epidermal Keratinocytes and the Expression of DEFB1 and SIRT1

    Researchers applied 7.8-Hz electromagnetic waves to normal human epidermal keratinocytes and investigated its effects on cell proliferation and migration, β-defensin (DEFB1), and sirtuin 1 (SIRT1) expression.
    [Journal of Cosmetic Dermatology]

    Full Article

    Activation of Melanocortin-1 Receptor Signaling in Melanoma Cells Impairs T Cell Infiltration to Dampen Antitumor Immunity

    Scientists reported that loss of melanocortin-1 receptor in melanoma cells activated antitumor T cell response and overcame resistance to immune checkpoint blockade.
    [Nature Communications]

    Full Article

    Chitosan Hydrogels with MK2 Inhibitor Peptide-Loaded Nanoparticles to Treat Atopic Dermatitis

    A cell-penetrating mitogen-activated protein kinase–activated protein kinase-2 (MK2) inhibitor peptide YARA was loaded into hollow thermo-responsive pNIPAM nanoparticles, which were further incorporated into chitosan hydrogels to promote local drug delivery, improve moisture and the anti-inflammatory activity.
    [Journal of Controlled Release]

    AbstractGraphical Abstract

    Anti-Atopic Dermatitis Effect of Fish Collagen on House Dust Mite-Induced Mice and HaCaT Keratinocytes

    Scientists investigated the anti-atopic dermatitis (AD) effects of fish collagen against house dust mite-induced AD in NC/Nga mice and TNF-α/IFN-γ-stimulated HaCaT keratinocytes.
    [Scientific Reports]

    Full Article

    Nuclear Translocation of PKM2 Mediates Keratinocyte Metabolic Reprogramming in Psoriasis

    Researchers investigated the function of PKM2 in psoriatic keratinocytes. They found that PKM2 expression and its nuclear translocation were induced in the epidermis of psoriasis patients,
    [Experimental Dermatology]

    Abstract

    Vitamin D3 Regulates NSUN2 Expression and Inhibits Melanoma Cell Proliferation and Migration

    The authors showed that vitamin D3 could significantly and specifically inhibit the proliferation and migration of melanoma B16 cells.
    [Molecular Diversity]

    Abstract
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    REVIEWS

    Human Epidermal Keratinocytes in Culture: A Story of Multiple Recipes for a Single Cell Type

    Investigators present a brief retrospective of the emergence of keratinocyte-based culture techniques. They also present opportunities and eventual problems that researchers might encounter when exploring the skin using such procedures.
    [Skin Pharmacology And Physiology]

    Abstract
    INDUSTRY AND POLICY NEWS

    EBGLYSS® (Lebrikizumab) Receives Positive CHMP Opinion for Moderate-to-Severe Atopic Dermatitis

    The Committee for Medicinal Products for Human Use (CHMP) issued a positive opinion recommending the marketing authorization of EBGLYSS for the treatment of adult and adolescent patients with moderate-to-severe atopic dermatitis, who are candidates for systemic therapy.
    [Almirall, S.A.]

    Press Release

    Possible Misconduct Found in Papers from Italian Minister of Health

    An Italian newspaper has found duplicated images in eight cancer papers co-authored by the country’s minister of health, Orazio Schillaci. Dr. Schillaci published the papers between 2018 and 2022 while working in the faculty of medicine of the University of Rome Tor Vergata.
    [Science Insider]

    Press Release
    FEATURED EVENT

    New Vista of Tissue Engineering & Regenerative Medicine

    October 16 – 19, 2023
    Hong Kong

    > See All Events

    JOB OPPORTUNITIES

    Clinical/Non-Clinical Senior Lecturer – Experimental Medicine

    King’s College London – London, England, United Kingdom

    Scientific Director – Intramural Research Program

    National Institute of Arthritis and Musculoskeletal and Skin Diseases – Bethesda, Maryland, United States

    PhD Position – Regulation of Skin Stem Cells during Epithelial Development

    Nottingham Trent University – Nottingham, England, United Kingdom

    Postdoctoral Scientist – Cancer Research Cluster

    Cedars-Sinai – Los Angeles, California, United States

    Senior Research Fellow – Cancer Genomics

    University of Melbourne – Melbourne, Australia

    > See All Jobs

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