Dermal Cell News Volume 9.32 | Sep 25 2023

September 25, 2023

2023-09-25 | DCN 9.32

Dermal Cell News by STEMCELL Technologies

Vol. 9.32 – 25 September, 2023

TOP STORY

Myc-Dependent Dedifferentiation of Gata6⁺ Epidermal Cells Resembles Reversal of Terminal Differentiation

Researchers integrated lineage tracing and single-cell mRNA sequencing to uncover the underlying mechanism of Gata6⁺ epidermal cell dedifferentiation.
[Nature Cell Biology]

Full Article

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PUBLICATIONSRanked by the impact factor of the journal

DERMAL STEM CELLS & TISSUE REGENERATION

Impact of Exposure to Atmospheric Particulate Matter in Human Skin-Derived Fibroblast Cells: A Metabolomics Approach for the Class of Amino Acids Based on GC×GC-Q-TOFMS/MS

The toxicity of particulate material to fibroblast cells derived from the human dermis was investigated using metabolomic analysis for the class of amino acids.
[Journal of Hazardous Materials]

Abstract

Loss of Dicer in Newborn Melanocytes Leads to Premature Hair Greying and Changes in Integrin Expression

Using two mouse genetic models and human and mouse cell lines, the authors found that the inactivation of Dicer in melanocytes led to a misplacement of these cells within the hair follicle.
[Journal of Investigative Dermatology]

Full Article

Fisetin, a Potential Skin Rejuvenation Drug That Eliminates Senescent Cells in the Dermis

Researchers investigated the effects of fisetin, a potential anti-aging component found in various edible fruits and vegetables, on senescent human dermal fibroblasts and aging human skin.
[Biogerontology]

Abstract

SKIN CANCERS & DISORDERS

Depletion of G9A Attenuates Imiquimod-Induced Psoriatic Dermatitis via Targeting EDAR-NF-κB Signaling in Keratinocyte

Scientists found that G9A was highly expressed in lesions of patients with psoriasis and imiquimod-induced psoriasis-like mouse model.
[Cell Death & Disease]

Full Article Graphical Abstract

Melanoma Cells Repress Desmoglein 1 in Keratinocytes to Promote Tumor Cell Migration

Investigators provided evidence that melanoma cells hijacked intercellular communications by secreting factors that keep Desmoglein 1 expression low in the surrounding keratinocytes.
[Journal of Cell Biology]

Abstract Press Release

4-Octyl Itaconate Inhibits Inflammation to Attenuate Psoriasis as an Agonist of Oxeiptosis

Scientists found that oxeiptosis of keratinocytes was inhibited in psoriasis lesions. KEAP1, as the upstream molecular component of oxeiptosis, was highly expressed in psoriasis lesions.
[International Immunopharmacology]

Abstract

Increase of ISG15 in Psoriasis Lesions and Its Promotion of Keratinocyte Proliferation via the Hif-1α Signaling Pathway

The expression of interferon stimulated gene 15 (ISG15) saw a significant increase through the immunohistochemical detection of imiquimod-induced mice. In the psoriasis cell model, a remarkable increase also occurred.
[Experimental Dermatology]

Abstract

Selective Adhesion Inhibition and Hyaluronan Envelope Reduction of Dermal Tumor Cells by Cold Plasma-Activated Medium

Researchers conducted a comparative study concerning the plasma sensitivity of dermal tumor cells versus non-tumorigenic dermal cells regarding their adhesion capacity.
[Cell Adhesion & Migration]

Full Article

STEMCELL has implemented an Environmental Management System that is now ISO 14001-certified.

REVIEWS

Skin Cancer Prevention – Recent Advances and Unmet Challenges

Investigators review the epidemiology, risk factors, and current cutaneous squamous cell carcinoma (cSCC) prevention strategies. They highlight the gaps and future clinical strategies to address cSCC risk in high-risk populations.
[Cancer Letters]

Abstract

INDUSTRY AND POLICY NEWS

NIH Upholds Controversial Plan to Step Up Oversight of Foreign Collaborators

Despite negative feedback from the research community, the US National Institutes of Health (NIH) has decided to move forward with a policy requiring that foreign scientists receiving ‘subawards’ from the agency must share their laboratory notebooks and other raw data with their research partner in the US.
[Nature News]

Press Release

FEATURED EVENT

Dermal Cell News Volume 9.32 | Sep 25 2023

Myc-Dependent Dedifferentiation of Gata6⁺ Epidermal Cells Resembles Reversal of Terminal Differentiation

Impact of Exposure to Atmospheric Particulate Matter in Human Skin-Derived Fibroblast Cells: A Metabolomics Approach for the Class of Amino Acids Based on GC×GC-Q-TOFMS/MS

Loss of Dicer in Newborn Melanocytes Leads to Premature Hair Greying and Changes in Integrin Expression

Fisetin, a Potential Skin Rejuvenation Drug That Eliminates Senescent Cells in the Dermis

Depletion of G9A Attenuates Imiquimod-Induced Psoriatic Dermatitis via Targeting EDAR-NF-κB Signaling in Keratinocyte

Melanoma Cells Repress Desmoglein 1 in Keratinocytes to Promote Tumor Cell Migration

4-Octyl Itaconate Inhibits Inflammation to Attenuate Psoriasis as an Agonist of Oxeiptosis

Increase of ISG15 in Psoriasis Lesions and Its Promotion of Keratinocyte Proliferation via the Hif-1α Signaling Pathway

Selective Adhesion Inhibition and Hyaluronan Envelope Reduction of Dermal Tumor Cells by Cold Plasma-Activated Medium

Skin Cancer Prevention – Recent Advances and Unmet Challenges

NIH Upholds Controversial Plan to Step Up Oversight of Foreign Collaborators

ESMO Congress 2023

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Clinical/Non-Clinical Senior Lecturer – Experimental Medicine

Scientific Director – Intramural Research Program

Research Associate – Tissue Immunology

Software Architect – Development of Skin Cancer Recognition Software

PhD Position – Regulation of Skin Stem Cells during Epithelial Development

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