Dermal Cell News Volume 9.33 | Oct 16 2023

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    Laurisa Dohm
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    2023-10-16 | DCN 9.33


    Dermal Cell News by STEMCELL Technologies
    Vol. 9.33 – 16 October, 2023
    TOP STORY

    Mpox Virus Infection and Drug Treatment Modeled in Human Skin Organoids

    Scientists demonstrated that hiPSC-derived skin organoids were susceptible to Mpox virus infection and support infectious virus production.
    [Nature Microbiology]

    Abstract
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    Multicellular Bioprinted Skin Facilitates Human-Like Skin Architecture In Vivo

    Six primary human skin cell types were used to bioprint a trilayer skin construct consisting of epidermis, dermis, and hypodermis.
    [Science Translational Medicine]

    AbstractPress Release

    Tracing Immune Cells Around Biomaterials with Spatial Anchors during Large-Scale Wound Regeneration

    Researchers presented a method for large-area wound regeneration using biodegradable aligned extracellular matrix scaffolds, and showed that the implantation of these scaffolds accelerated wound coverage and enhanced hair follicle neogenesis.
    [Nature Communications]

    Full Article

    Carnitine Acetyltransferase Deficiency Mediates Mitochondrial Dysfunction-Induced Cellular Senescence in Dermal Fibroblasts

    Carnitine acetyltransferase knockdown caused mitochondrial dysfunction, as indicated by increased oxidative stress, disruption of mitochondrial morphology, and a metabolic shift from oxidative phosphorylation to glycolysis.
    [Aging Cell]

    Full Article

    A Self-Healing Hydrogel Wound Dressing Based on Oxidized Bletilla striata Polysaccharide and Cationic Gelatin for Skin Trauma Treatment

    The novel hydrogel significantly facilitated wound healing by promoting hair follicles regeneration, blood vessels repair, collagen deposition, and inducing skin tissue remodeling via increased CD31 expression in a full-thickness skin wound rat model.
    [International Journal Of Biological Macromolecules]

    Full Article

    Uncovering the Complex Relationship between Balding, Testosterone and Skin Cancers in Men

    The authors dissected this relationship via Mendelian randomization analyses, using genetic data from recent male-only meta-analyses of cutaneous melanoma and keratinocyte cancers, followed by stratified Mendelian randomization analysis by body-sites.
    [Nature Communications]

    Full ArticlePress Release

    NRF3 Suppresses Squamous Carcinogenesis, Involving the Unfolded Protein Response Regulator HSPA5

    NRF3 protein expression was strongly downregulated, or even absent, in invasively growing cancer cells of patients with basal and squamous cell carcinomas.
    [EMBO Molecular Medicine]

    Full ArticleGraphical Abstract

    Glycyl-tRNA Synthetase Induces Psoriasis-Like Skin by Facilitating Skin Inflammation and Vascular Endothelial Cell Angiogenesis

    Glycyl-tRNA synthetase (GARS) was highly expressed in human skin keratinocytes, and GARS knockdown in keratinocytes suppressed cell proliferation and promoted apoptosis via the nuclear factor kappa-B/mitogen-activated protein kinase signaling pathway.
    [Journal Of Investigative Dermatology]

    AbstractGraphical Abstract

    Inhibition of IL-17 Ameliorates Keratinocyte-Borne Cytokine Responses in an In Vitro Model for House-Dust-Mite Triggered Atopic Dermatitis

    Peripheral blood mononuclear cells derived from respectively sensitized atopic dermatitis patients were stimulated with house dust mite extract and cell culture supernatants were applied subsequently in absence or presence of secukinumab to primary human keratinocytes.
    [Scientific Reports]

    Full Article
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    REVIEWS

    Engineered Extracellular Vesicles in Wound Healing: Design, Paradigms, and Clinical Application

    Scientists introduce the latest progress in the design methods and experimental paradigms of engineered extracellular vesciles (EVs) applied in wound repair, and comprehensively analyze the current clinical research status and prospects of engineered EVs within this field.
    [Small]

    Abstract

    Layer-by-Layer Analysis of In Vitro Skin Models

    The authors summarize the recent developments in in vitro skin models, with a focus on their applications, limitations, and future directions.
    [ACS Biomaterials Science & Engineering]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Astria Scratches Dealmaking Itch, Paying Ichnos $15M to Join Eczema Race Led by Amgen, Sanofi

    Ichnos Sciences has finally found a buyer for its OX40 eczema program. Astria Therapeutics has taken the other side of the deal, paying $15 million upfront to secure a spot at the back of a race led by Amgen and Sanofi.
    [Fierce Biotech]

    Editorial
    FEATURED EVENT

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    JOB OPPORTUNITIES

    Clinical Research Coordinator – Rheumatology

    Cedars-Sinai – Los Angeles, California, United States

    Doctoral Positions – Biomedical Research

    Berlin Institute of Health at Charité – Berlin, Germany

    Scientific Director – Intramural Research Program

    National Cancer Institute – Bethesda, Maryland, United States

    PhD Position – Regulation of Skin Stem Cells during Epithelial Development

    Nottingham Trent University – Nottingham, England, United Kingdom

    Postdoctoral Scientist – Cancer Research Cluster

    Cedars-Sinai – Los Angeles, California, United States

    > See All Jobs

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