Dermal Cell News Volume 9.34 | Oct 23 2023

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    Laurisa Dohm
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    2023-10-23 | DCN 9.34


    Dermal Cell News by STEMCELL Technologies
    Vol. 9.34 – 23 October, 2023
    TOP STORY

    Novel Methodologies for Host-Microbe Interactions and Microbiome-Targeted Therapeutics in 3D Organotypic Skin Models

    The authors presented a novel methodology for microbial colonization of organotypic skin and analysis thereof.
    [Microbiome]

    Full Article
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    PUBLICATIONSRanked by the impact factor of the journal

    Incorporation of Hair Follicles in 3D Bioprinted Models of Human Skin

    The tissue developed hair follicle–like structures upon maturation, supported by migration of keratinocytes and melanocytes, and their morphology and composition grossly mimicked that of the native skin tissue.
    [Science Advances]

    Full Article

    Determining the Structure of Protein-Bound Ceramides, Essential Lipids for Skin Barrier Function

    Researchers confirmed the presence of Cys-bound epoxy-enone ceramides in mouse epidermis by mass spectrometry analysis of protease-digested epidermis samples.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Contributions of Viral Oncogenes of HPV-18 and Hypoxia to Oxidative Stress and Genetic Damage in Human Keratinocytes

    Scientists studied the combined effect of viral oncoproteins E5, E6 and E7 and hypoxia in increasing oxidative stress and promoting DNA damage and nuclear architecture alterations.
    [Scientific Reports]

    Full Article

    Effects of Oxytocin on the Hair Growth Ability of Dermal Papilla Cells

    The authors examined the effects of oxytocin on dermal papilla cells that control hair growth by secreting growth/regression signals, and tested the hair growth-promoting effects of oxytocin using in vitro hair follicle organoids.
    [Scientific Reports]

    Full Article

    Androgen Receptor Is a Determinant of Melanoma Targeted Drug Resistance

    Researchers reported that androgen receptor (AR) activity was required for melanoma cell proliferation and tumorigenesis, and showed here that AR expression was markedly increased in BRAF/MEK inhibitor-resistant melanoma cells, and in sensitive cells soon after BRAFi exposure.
    [Nature Communications]

    Full Article

    Inhibition of TGF-β Signaling, Invasion, and Growth of Cutaneous Squamous Cell Carcinoma by PLX8394

    Investigators showed that the next-generation B-Raf inhibitor PLX8394 blocked TGF-β signaling in ras-transformed metastatic epidermal keratinocytes harboring wild-type B-Raf and hyperactive Ras.
    [Oncogene]

    Full Article

    SOX10 Loss Sensitizes Melanoma Cells to Cytokine-Mediated Inflammatory Cell Death

    Scientists observed that genetic ablation of SOX10 rendered melanoma cells more sensitive to CD8+ T cell-mediated killing and cell death induction by either TNFα or IFNγ.
    [Molecular Cancer Research]

    Abstract

    CRISPR/Cas9 Based Non-Viral Gene Editing Therapy for Topical Treatment of Recessive Dystrophic Epidermolysis Bullosa

    CRISPR/Cas9 plasmids delivered by the selcted highly branched poly(β amino ester)s achieved efficient targeted deletion and restored bulk C7 production in recessive dystrophic epidermolysis bullosa patient keratinocyte polyclones.
    [Molecular Therapy-Methods & Clinical Development]

    AbstractGraphical Abstract
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    REVIEWS

    Nanotechnology-Based Techniques for Hair Follicle Regeneration

    Scientists review hair follicle-specific targeting strategies, with particular emphasis on currently used nanotechnology-based strategies for both hair loss-related diseases and hair follicle regeneration.
    [Biomaterials]

    Full ArticleGraphical Abstract

    Electrospun Fibers for the Treatment of Skin Diseases

    The authors give an overview of the potential applications of electrospun fibers in skin therapy. In addition to the treatment of bacterial, diabetic and burn wounds, focus is placed on inflammatory diseases such as atopic dermatitis and psoriasis.
    [Journal Of Controlled Release]

    Full ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    BIMZELX® Approved by the US FDA for the Treatment of Adults with Moderate to Severe Plaque Psoriasis

    Bimekizumab is the first and only approved psoriasis treatment designed to selectively inhibit two key cytokines driving inflammatory processes – interleukin 17A and interleukin 17F.
    [UCB]

    Press Release
    FEATURED EVENT

    Donor Selection & Cell Source Summit

    November 28 – 30, 2023
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    JOB OPPORTUNITIES

    Postdoctoral Scientist – Skin Cancer and Aging

    Cancer Research UK Manchester Institute – Manchester, England, United Kingdom

    Postdoctoral Fellow – Cancer Research

    University of Gothenburg – Gothenburg, Sweden

    Assistant Professor – Biochemistry and Molecular and Cellular Biology

    Georgetown University – Washington, Pennsylvania, United States

    Doctoral Positions – Biomedical Research

    Berlin Institute of Health at Charit̩ РBerlin, Germany

    Clinical Research Coordinator – Rheumatology

    Cedars-Sinai – Los Angeles, California, United States

    > See All Jobs

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