 | | Vol. 9.35 – 30 October, 2023 |
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| Scientists showed that biomimetic iron single-atom catalysts with broad-spectrum reactive oxygen species (ROS) scavenging capability could be used for psoriasis treatment and relapse prevention via related gene restoration.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| Using electrochemical analysis on human hair follicle preparations in vitro, researchers were able to show that outer root sheath cells released ATP and the neurotransmitters serotonin and histamine in response to mechanical stimulation.
[Science Advances] |
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| The authors developed a novel method involving physicochemical and enzymatic treatment of cadaveric human skin to obtain human acellular dermal matrix scaffold.
[Stem Cell Research & Therapy] |
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| Using previously established mouse full-thickness wounds, scientists showed that Bcl-2 and adenovirus E1B 19-kDa interacting protein 3 (BNIP3) expression was significantly elevated at the wound edge, and hypoxia treatment enhanced BNIP3 expression in fibroblasts.
[FEBS Journal] |
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| The authors addressed the lack of cell models for mucosal melanoma by establishing 30 organoids of human oral mucosal melanoma, which retained major histopathological and functional features of parental tumors
[Science Advances] |
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| Researchers discovered a key function of Transglutaminase Type-2 in regulating melanogenesis by modulating MITF transcription factor expression and its transcriptional activity.
[Cell Death & Disease] |
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| In the imiquimod-induced psoriasis-like mouse model, oral administration of the optimized compound for one week significantly alleviated modified psoriasis area and severity index scores, compared with the control group.
[Journal Of Medicinal Chemistry] |
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| A dinitrochlorobenzene (DNCB)-induced atopic dermatitis mouse model was established and treated with low, medium, and high doses of Rosmarinus officinalis essential oil.
[Biomedicine & Pharmacotherapy] |
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| HaCaT cells were stimulated by TNF-α with or without liquiritin, harvested for analysis by western blots and RT-qPCR, and the cellular supernatants were collected and analyzed by ELISA for cytokines.
[Phytotherapy Research] |
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| The authors shed light on the implications of pathological dysregulation of the NLRP1 inflammasome in skin diseases and investigate the potential rationale for targeting this pathway as a future therapeutic approach.
[British Journal Of Dermatology] |
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| Deciphering the genetic basis of a number of inherited conditions has delineated the pivotal role played in this process by a series of proteases and protease inhibitors, including serpins, cathepsins, and cystatins, suggesting novel avenues for therapeutic intervention in both rare and common disorders of cornification.
[Journal Of Investigative Dermatology] |
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| The company is primed to launch a Phase I clinical study, aiming to assess the safety, tolerability, and preliminary efficacy of SPX-303 in patients beleaguered by advanced or refractory solid tumors.
[SparX Biopharmaceutical Corp. (Cision Newswire)] |
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| December 2 – 6, 2023
Boston, Massachusetts, United States |
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| | UC San Diego – San Diego, California, United States |
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| | Cancer Research UK Manchester Institute – Manchester, England, United Kingdom |
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| | University of Gothenburg – Gothenburg, Sweden |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | National Cancer Institute – Bethesda, Maryland, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
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