 | | Vol. 9.37 – 20 November, 2023 |
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| Researchers found that expressing a constitutively active oncogenic mutant version of Smoothened (SMO) that induces the development of basal cell carcinoma in the ear epidermis of mice induced clonal expansion together with tumor initiation and invasion.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| Scientists identified a multipotent fibroblast progenitor marked by CD201 expression in the fascia, the deepest connective tissue layer of the skin.
[Nature] |
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| The proteins compensated the skin microenvironment for permanent neurological damage after burns to initiate peripheral nerve regeneration and hair follicle niche formation.
[ACS Nano] |
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| The MOF-808 crystals were applied to in vivo skin wound model as a hydrogel dispersion. The hydrogel containing 0.2 wt% MOF-808 crystals showed significant improvement in terms of wound healing efficacy and quality over the corresponding control.
[Advanced Healthcare Materials] |
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| Investigators performed epithelial-mesenchymal tissue recombination experiments using hair-forming back skin and glabrous plantar skin from mouse embryos to unveil that the back skin mesenchyme was inductive even before dermal condensate formation.
[Development] |
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| Abrogation of Ataxia-telangiectasia mutated (ATM) kinase inhibitors expression in melanoma cells via CRISPR-mediated gene knockout reduced 3D invasion in vitro as well as spontaneous lymph node metastasis in vivo.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| The expression level of plasmacytoma variant translocation 1 (PVT1) was quantified in normal skin, premalignant skin lesion actinic keratosis and cutaneous squamous cell carcinomas by qRT-PCR and single molecule in situ hybridization.
[British Journal Of Dermatology] |
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| Mechanistically, activated keratinocytes produced chemokines and cytokines that triggered neutrophil chemotaxis and activation in a fatty acid binding protein 5 (FABP5)-dependent manner.
[Cell Reports] |
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| Investigators conducted experiments focusing on the antifibrotic and anti-inflammatory effects of apremilast using dermal fibroblasts derived from patients with systemic sclerosis and an systemic sclerosis mouse model.
[Scientific Reports] |
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| The authors provide an overview of mRNA cancer vaccines by discussing their utility in treating melanoma.
[ACS Applied Bio Materials] |
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| Article-processing charges levied by publishers on authors have become an integral — and sometimes unpopular — part of the open-access revolution. Other options are being explored.
[Nature] |
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| December 4 – 7, 2023
Dublin, Ireland |
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| | Temple University – Philadelphia, Pennsylvania, United States |
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| | Babraham Institute – Cambridge, England, United Kingdom |
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| | University of Cambridge – Cambridge, England, United Kingdom |
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| | Stony Brook University – Stony Brook, New York, United States |
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| | University of Edinburgh – Edinburgh, Scotland, United Kingdom |
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