 | | Vol. 9.38 – 27 November, 2023 |
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| The authors introduced an advanced human skin equivalent and used tsetse flies to naturally infect the skin with trypanosomes.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| Researchers studied cardinal features important for tissue patterning and hair regeneration, finding that they spontaneously formed spheroid configurations, with polarized epidermal cells coupled with dermal cells through a newly formed basement membrane.
[NPJ Regenerative Medicine] |
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| Scientists engineered mice that kept physiological expression of collagen VII only in epithelial cells or in fibroblasts, revealing that production of collagen VII either by keratinocytes or fibroblasts alone was sufficient for creation of mechanically robust skin.
[Journal Of Investigative Dermatology] |
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| Investigators presented the results of a readily accessible machine learning-based pipeline that used standard fluorescence microscope and open access software to quantify the minute morphological changes that human fibroblasts undergo during their replicative lifespan in culture.
[Geroscience] |
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| Scientists synthesized chitosan nanoparticles containing a chemically modified miR126 sequence, which were further functionalized with an antibody specific to the chondroitin sulfate proteoglycan 4 melanoma marker.
[Molecular Therapy] |
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| miR-4488 and miR-4443 were measured by qRT-PCR. Nestin levels were tested by western blot, confocal immunofluorescence, immunohistochemical and flow cytometry analyses.
[Journal Of Experimental & Clinical Cancer Research] |
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| In vivo studies revealed that repeated particulate matter exposure to intact skin resulted in cutaneous inflammatory responses, including increased skin thickness and mast cell infiltration.
[ACS Applied Materials & Interfaces] |
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| In vitro experiments using HaCaT cells demonstrated that sulforaphane inhibited IL-22 and TNF-α-induced activation of inflammatory pathways and keratinocyte proliferation.
[Cell Death & Disease] |
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| Primary pooled keratinocytes and a keratinocyte cell line were stimulated with contact allergens, and inflammatory responses and expression of metabolic markers were measured by qPCR and flow cytometry, respectively.
[Contact Dermatitis] |
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| The authors focus on intracellular and molecular mechanisms such as AhR, A3AR, RIP1, CGRP, and S1P that serve as novel pharmacological targets for psoriasis, and on new molecules now approved or under clinical investigation to interfere with these target mechanisms.
[Expert Opinion On Therapeutic Targets] |
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| The number of top researchers affiliated with universities in Saudi Arabia has dropped sharply, months after the institutions were revealed to be enticing eminent scientists abroad to declare a Saudi affiliation—often in exchange for cash—in a bid to boost their rankings.
[SCIENCEINSIDER] |
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| January 16 – 19, 2024
San Diego, California, United States & Virtual |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | Temple University – Philadelphia, Pennsylvania, United States |
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| | Babraham Institute – Cambridge, England, United Kingdom |
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| | Armenian Bioinformatics Institute – Yerevan, Armenia |
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| | Stony Brook University – Stony Brook, New York, United States |
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