 | | Vol. 9.40 – 11 December, 2023 |
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| Investigators discovered that systemically administered CAR (CARSKNKDC) peptide had inherent ability to promote wound healing: wounds closed and re-epithelialized faster in CAR-treated male mice.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| Using an innovative planar-sagittal live imaging technique to visualize the basement membrane of developing skin, researchers directly observed basement membrane deformation during hair follicle budding and basal progenitor cell divisions.
[Journal Of Cell Biology] |
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| The authors conducted a comprehensive time-series analysis by combining scRNA sequencing datasets collected at different stages of development and validated our findings through multi-panel in situ spatial transcriptomics.
[Journal Of Investigative Dermatology] |
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| Investigators identified some of the major technical barriers that have impacted regulatory recognition of an in vitro skin model for this purpose and proposed how these could be overcome on-chip using artificial cells engineered from the bottom-up.
[Lab On A Chip] |
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| Scientists provide an in-depth insight into the role of ∆Np63α in the development of squamous cell carcinomas during different stages of tumor formation and how it may be targeted for therapeutic implications.
[Biochimica Et Biophysica Acta-Reviews On Cancer] |
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| The authors established matched immortalized human frontal and occipital scalp dermal papilla (DP) cell lines from ndrogenetic alopecia patients. Simian virus 40 large T antigen and human telomerase reverse transcriptase were introduced into primary human DP cells.
[Scientific Reports] |
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| Through the CRISPR/Cas9 system, researchers performed a specific cleavage only on the mutant allele and restored a normal cellular phenotype and a correct intermediate filament network, without affecting the epidermal stem cells, which played a crucial role in epidermal regeneration.
[Molecular Therapy] |
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| Through transcriptomic analysis of primary and metastatic melanoma, it was confirmed that in metastatic samples, some of the 97 down-regulated genes participate in maintaining skin homeostasis while 42 up-regulated genes were enriched in cancer-related functions.
[Aging] |
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| Transglutaminase-1 immunoreactivity initially increased and co-localized with membrane-associated transglutaminase activity during keratinocyte differentiation.
[Scientific Reports] |
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| | Scientists provide an in-depth insight into the role of ∆Np63α in the development of squamous cell carcinomas during different stages of tumor formation and how it may be targeted for therapeutic implications.
[Biochimica Et Biophysica Acta-Reviews On Cancer] |
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| Dermavant Sciences announced positive results from its Phase IV, open-label clinical trial of VTAMA® cream, 1% for the treatment of plaque psoriasis in the head and neck region in adults.
[Dermavant Sciences] |
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| February 14 – 18, 2024
Cancun, Mexico |
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| | Albert-Ludwigs-University Freiburg – Freiburg im Breisgau, Germany |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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| | Helmholtz Association of German Research Centres – Heidelberg, Germany |
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| | BC Cancer – Vancouver, British Columbia, Canada |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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