Endothelial Cell News 5.37 | Oct 26 2020

May 12, 2022

2020-10-26 | ENDOCN 5.37

Endothelial Cell News by STEMCELL Technologies

Vol. 5.37 – 26 October, 2020

TOP STORY

TGF-β Suppresses Type 2 Immunity to Cancer

The authors showed that depletion of transforming growth factor-β receptor 2 (TGFβR2) in CD4⁺ T cells, but not CD8⁺ T cells, halts cancer progression as a result of tissue healing and remodeling of the blood vasculature, causing cancer cell hypoxia and death in distant avascular regions.

Abstract Press Release

Activate, expand, and differentiate your cells with cytokines, chemokines, and growth factors from STEMCELL Technologies.

PUBLICATIONSRanked by the impact factor of the journal

Timed
Ang2-Targeted Therapy Identifies the Angiopoietin-Tie Pathway as Key Regulator of Fatal Lymphogenous Metastasis

Investigators established a GEMM fragment-based tumor model uniquely sustaining a functional network of intratumoral lymphatics that facilitated seeding of fatal peripheral metastases.
[Cancer Discovery]

Abstract Press Release

Direct
Reprogramming of Human Umbilical Vein- and Peripheral Blood-Derived Endothelial Cells into Hepatic Progenitor Cells

Scientists showed that a set of three transcription factors, FOXA3, HNF1A, and HNF6, could induce human umbilical vein endothelial cells to directly acquire the properties of human hepatic progenitor cells.
[Nature Communications]

Full Article

The
GEF Trio Controls Endothelial Cell Size and Arterial Remodeling Downstream of Vegf Signaling in Both Zebrafish and Cell Models

Using zebrafish embryos and endothelial cell models, researchers describe an alternative, flow independent model, involving enlargement of arterial endothelial cells, which resulted in the formation of large diameter arteries.
[Nature Communications]

Full Article

YAP
Orchestrates Heterotypic Endothelial Cell Communication via HGF/C-MET Signaling in Liver Tumorigenesis

In yes-associated protein (YAP)S127A-induced tumorigenesis, a gradual replacement of liver sinusoidal endothelial cells by continuous endothelial cells was associated with dynamic changes in the expression of genes involved in paracrine communication.
[Cancer Research]

Abstract

Tumor
Exposed-Lymphatic Endothelial Cells Promote Primary Tumor Growth via IL6

Investigators revealed a new mechanism by which tumor exposed-lymphatic endothelial cells (teLEC) exert mitogenic effects on tumor cells. Their conclusions were supported by morphological and molecular changes induced in teLEC that in turn enhance cancer cell invasion in 3D cultures and tumor cell proliferation in vivo.
[Cancer Letters]

Full Article

Transport
of Ultrasmall Gold Nanoparticles (2 nm) across the Blood–Brain Barrier in a Six-Cell Brain Spheroid Model

The spheroids used were composed of six brain cell types: Astrocytes, pericytes, endothelial cells, microglia cells, oligodendrocytes, and neurons. They formed an in vitro blood brain barrier that regulated the transport of compounds into the spheroid.
[Scientific Reports]

Full Article

MicroRNA-34a
Promotes Apoptosis of Retinal Vascular Endothelial Cells by Targeting SIRT1 in Rats with Diabetic Retinopathy

miR-34a interacted with SIRT1 and suppressed SIRT1 expression. MiR-34a overexpression inhibited proliferation and promoted apoptosis of rat retinal vascular endothelial cells, which was effectively abolished by SIRT1 up-regulation.
[Cell Cycle]

Abstract

Effect of Ergothioneine on 7-Ketocholesterol-Induced Endothelial Injury

Endothelial cells were exposed to high levels of the cholesterol oxidation product, 7-ketocholesterol, in patients with cardiovascular disease and diabetes, and this process is thought to mediate pathological inflammation.
[NeuroMolecular Medicine]

Full Article

Atorvastatin
and Pravastatin Stimulate Nitric Oxide and Reactive Oxygen Species Generation, Affect Mitochondrial Network Architecture and Elevate Nicotinamide N-Methyltransferase Level in Endothelial Cells

The side effects of pravastatin and atorvastatin on the EA.hy926 endothelial cell line were investigated. It was found that both statins activated proinflammatory responses, elevated nitric oxide and reactive oxygen species generation and stimulated antioxidative response in these cells.
[Journal of Applied Toxicology]

Abstract

PRL-2 Phosphatase Is Required for Vascular Morphogenesis and Angiogenic Signaling

Researchers showed that endothelial cells in the retina express Phosphatase of Regenerative Liver (PRL)-2 encoded by the Ptp4a2 gene, and that inducible endothelial and global Ptp4a2 mutant mice exhibited defective retinal vascular outgrowth, arteriovenous differentiation, and sprouting angiogenesis.
[Communications Biology]

Full Article

REVIEWS

Endothelial
Dysfunction in Neuroprogressive Disorders— Causes and Suggested Treatments

The authors provide details of potential treatment options for mitigating endothelial cell dysfunction and activation in neuroprogressive disorders.
[BMC Medicine]

Abstract

INDUSTRY AND POLICY NEWS

UNL Biochemists Earn $1.8 Million Grant to Study Tight Junctions

A group of biochemists at the University of Nebraska-Lincoln (UNL) earned a five-year, $1.8 million grant to understand the structure, function and dysfunction of tight junctions.
[The Daily Nebraskan]

Press Release

FEATURED EVENT

TGF-β Suppresses Type 2 Immunity to Cancer

Timed
Ang2-Targeted Therapy Identifies the Angiopoietin-Tie Pathway as Key Regulator of Fatal Lymphogenous Metastasis

Direct
Reprogramming of Human Umbilical Vein- and Peripheral Blood-Derived Endothelial Cells into Hepatic Progenitor Cells

The
GEF Trio Controls Endothelial Cell Size and Arterial Remodeling Downstream of Vegf Signaling in Both Zebrafish and Cell Models

YAP
Orchestrates Heterotypic Endothelial Cell Communication via HGF/C-MET Signaling in Liver Tumorigenesis

Tumor
Exposed-Lymphatic Endothelial Cells Promote Primary Tumor Growth via IL6

Transport
of Ultrasmall Gold Nanoparticles (2 nm) across the Blood–Brain Barrier in a Six-Cell Brain Spheroid Model

MicroRNA-34a
Promotes Apoptosis of Retinal Vascular Endothelial Cells by Targeting SIRT1 in Rats with Diabetic Retinopathy

Effect of Ergothioneine on 7-Ketocholesterol-Induced Endothelial Injury

Atorvastatin
and Pravastatin Stimulate Nitric Oxide and Reactive Oxygen Species Generation, Affect Mitochondrial Network Architecture and Elevate Nicotinamide N-Methyltransferase Level in Endothelial Cells

PRL-2 Phosphatase Is Required for Vascular Morphogenesis and Angiogenic Signaling

Endothelial
Dysfunction in Neuroprogressive Disorders— Causes and Suggested Treatments

UNL Biochemists Earn $1.8 Million Grant to Study Tight Junctions

Keystone
Symposia: Tumor Metabolism and the Microenvironment

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Research Associate – Cerebrovascular Development and Disease

Postdoctoral Researcher – Endothelial Cell Metabolism in Illness

Postdoctoral
/ PhD Student – Placental Vascular Immune Response

Postdoctoral Fellowship – Clinical Research in Autonomic Dysfunctions

Postdoctoral
Associate – Endovascular Research

> See All Jobs