Endothelial Cell News Volume 1.01 | Mar 14 2016

Three-Dimensional Bioprinting of Thick Vascularized Tissues
Investigators report a method for bioprinting 3D cell-laden, vascularized tissues that exceed 1 cm in thickness and can be perfused on chip for long time periods. They integrated parenchyma, stroma, and endothelium into a single thick tissue by coprinting multiple inks composed of human mesenchymal stem cells and human neonatal dermal fibroblasts within a customized extracellular matrix alongside embedded vasculature, which is subsequently lined with human umbilical vein endothelial cells. [Proc Natl Acad Sci USA]
Abstract | Full Article | Press Release | Video

Morphogenesis of 3D Vascular Networks Is Regulated by Tensile Forces
The authors assessed the effect of uniaxial cell-induced and externally applied tensile forces on the morphology of vascular networks formed within fibroblast and endothelial cell-embedded 3D polymeric constructs. [Proc Natl Acad Sci USA] Abstract

Role of Moesin in Advanced Glycation End Products-Induced Angiogenesis of Human Umbilical Vein Endothelial Cells
Researchers investigated the impact of moesin on advanced glycation end product-induced human umbilical vein endothelial cell proliferation, migration, and tubulogenesis. Silencing of moesin decreased cell motility and tube formation but not cell proliferation. [Sci Rep] Full Article

E-Selectin-Targeting Delivery of MicroRNAs by Microparticles Ameliorates Endothelial Inflammation and Atherosclerosis
Scientists tested the hypothesis that delivery of microRNA (miR)-146a and miR-181b with an E-selectin-targeting multistage vector to inflamed endothelium covering atherosclerotic plaques inhibits atherosclerosis. [Sci Rep] Full Article

The Effects of Microvesicles on Endothelial Progenitor Cells Are Compromised in Type 2 Diabetic Patients via Downregulation of miR-126/VEGFR2 Pathway
The effects of circulating microvesicles (MVs) and endothelial progenitor cell (EPC) derived MVs on EPC migration, apoptosis and reactive oxygen species production in healthy controls, well-controlled and uncontrolled diabetic patients were investigated. [Am J Physiol Endocrinol Metab] Abstract

Lymphatic Endothelial Cells Efferent to Inflamed Joints Produce iNOS and Inhibit Lymphatic Vessel Contraction and Drainage in TNF-Induced Arthritis in Mice
Scientists determined the cellular source of inducible nitric oxide synthase (iNOS) induced in lymphatic endothelial cells in response to tumor necrosis factor (TNF), the effects of iNOS on lymphatic smooth muscle cell function and on the development of arthritis in TNF-transgenic mice, and whether iNOS inhibitors improve lymphatic function and reduce joint destruction in inflammatory erosive arthritis. [Arthritis Res Ther] Full Article

Effects of Transplanted Circulating Endothelial Progenitor Cells and Platelet Microparticles in Atherosclerosis Development
Scientists investigated the possible protective role of a cell therapy-based approach using endothelial progenitor cells and the dual behaviour of circulating platelet microparticles on atherosclerosis development in hypertensive-hypercholesterolemic hamster model. [Biol Cell] Abstract

Neuromuscular Electrical Stimulation Acutely Mobilizes Endothelial Progenitor Cells in Critically Ill Patients with Sepsis
Investigators explored the neuromuscular electric stimulation-induced effects on mobilization of endothelial progenitor cells in septic ICU patients. [Ann Intensive Care] Full Article

The Vascular Endothelial Growth Factor Inhibitors Ranibizumab and Aflibercept Markedly Increase Expression of Atherosclerosis-Associated Inflammatory Mediators on Vascular Endothelial Cells
Investigators sought to assess the in vitro effects of Ranibizumab and Aflibercept on the expression of key inflammatory mediators on endothelial cells. [PLoS One] Full Article

A Three-Dimensional Culture System Recapitulates Placental Syncytiotrophoblast Development and Microbial Resistance
Researchers describe a three-dimensional–based culture model using human JEG-3 trophoblast cells that develop syncytiotrophoblast phenotypes when cocultured with human microvascular endothelial cells. JEG-3 cells cultured in this system exhibited enhanced fusogenic activity and morphological and secretory activities strikingly similar to those of primary human syncytiotrophoblasts. [Sci Adv] Abstract | Press Release

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EUSA Pharma and AVEO Announce Submission of Marketing Authorization Application for Tivozanib in Advanced Renal Cell Carcinoma
EUSA Pharma and AVEO Oncology announced the submission of a Marketing Authorization Application to the European Medicines Agency for tivozanib for the first-line treatment of advanced renal cell carcinoma. [EUSA Pharma] Press Release

Cancer MoonShot 2020 Community Oncology Milestone: National Immunotherapy Coalition (NIC) Partners with New England Cancer Specialists to Advance Cancer Care in New England
Cancer MoonShot 2020 announced its clinical affiliation with New England Cancer Specialists, aimed to greatly expand patients’ access to advanced cancer care, innovative clinical trials, and survivorship resources in the community. [Cancer MoonShot 2020] Press Release

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Postdoctoral Fellow – Ion Channel Signaling and Metabolism (University of Iowa Carver College of Medicine)

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