Endothelial Cell News 1.17 July 11, 2016 | |
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TOP STORYGoing to ‘Wars’ against Cancer and Heart Disease Researchers discovered a new gene that controls blood vessel formation. This work presents a possible new drug target for cancer and heart disease. [Press release from Duke-National University of Singapore Medical School discussing online publication in Nature Communications] Press Release | Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Solid Tumor Therapy by Selectively Targeting Stromal Endothelial Cells Using a range of tissue-specific loss-of-function and gain-of-function genetic models, researchers determined that the in vivo toxin sensitivity requires capillary morphogenesis protein-2 expression on host-derived tumor endothelial cells. Notably, engineered toxins were shown to suppress the proliferation of isolated tumor endothelial cells. [Proc Natl Acad Sci USA] Abstract EPCs Enhance Angiogenesis in Renal Regeneration Administration of exogenous endothelial progenitor cells (EPCs) promotes angiogenesis and vasculogenesis in decellularized renal scaffolds-mediated renal regeneration, providing adequate microenvironment for kidney recovery post renal injury. [Oncotarget] Full Article Bilirubin is an Endogenous Antioxidant in Human Vascular Endothelial Cells Researchers measured bilirubin in both arterial and venous rat endothelium. In the human endothelial Ea.hy926 cell line, they demonstrated that intracellular bilirubin could be modulated by either extracellular bilirubin uptake, or by up-regulation of heme oxygenase-1, a cellular enzyme related to endogenous bilirubin synthesis. [Sci Rep] Full Article Scientists identified novel heme oxygenase-1 (HO-1) targets involved in angiogenesis. HO-1 depletion attenuated vascular endothelial growth factor-induced human endothelial cell proliferation and tube formation. [Sci Rep] Full Article Glycine Inhibits Angiogenesis in Colorectal Cancer: Role of Endothelial Cells The authors evaluated anti-angiogenic effects of glycine in colorectal cancer. Glycine was added to cultures of human and rat colorectal cancer cells, and endothelial cells. [Amino Acids] Abstract Scientists explored the causal role of focal adhesion kinase (FAK) in inducing vascular endothelial growth factor-C (VEGF-C) expression in interleukin-6 (IL-6)-stimulated murine lymphatic endothelial cells. FAK signaling blockade by NSC 667249 attenuated IL-6-induced VEGF-C expression and VEGF-C promoter-luciferase activities. [PLoS One] Full Article Pleiotropic Effects of Survivin in Vascular Endothelial Cells Compared to non-infected or control adenovirus-infected rat aortic endothelial cells (RAECs) in vitro, survivin (SVV)-expressing cells had increased viability and migratory capability, but reduced apoptosis. In vivo, SVV-expressing RAECs were associated with a higher level of angiogenesis. [Microvasc Res] Abstract Primary cells isolated from two different tissues of the same animal, rat bone marrow stem cells and rat aortic endothelial cells were co-cultured to study the effects of co-culturing on both osteogenesis and angiogenesis. [Microvasc Res] Abstract | |
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REVIEWSFunctional Definition of Endothelial Progenitor Cells: A Molecular Perspective Since the discovery of endothelial progenitor cells (EPCs) almost two decades ago, there has been great hope in their use in treating chronic ischemic disease. Unfortunately, to date, many of the clinical trials using EPCs have been hampered by the lack of clear definition of this cell population. [Stem Cells Transl Med] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field.
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SCIENCE NEWSMerck presented data from the pivotal Phase III TAILOR study in patients from China, the first prospective trial to evaluate an anti-EGFR antibody in the first-line therapy of patients with RAS wild-type metastatic colorectal cancer. [Press release from Merck & Co., Inc. discussing research presented at the ESMO 18th World Congress on Gastrointestinal Cancer (WCGC), Barcelona] Press Release | |
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INDUSTRY NEWSAngionetics Inc. announced that it has entered into an exclusive territorial distribution and license agreement with an entity affiliated with Huapont Life Sciences Co., Ltd. for Huapont to clinically develop, market and sell the Generx® angiogenic gene therapy product candidate in Mainland China. [Angionetics Inc.] Press Release Arizona Patient Will Receive First U.S.-Approved Fully Dissolving Heart Stent A heart stent that dissolves completely over time and that represents the next major advance in coronary artery disease treatment will be implanted in the first U.S. patient at HonorHealth Scottsdale Shea Medical Center. The revolutionary device received approval from the U.S. Federal Drug Administration on July 5 after years of clinical research and trials. [HonorHealth (PR Newswire Association LLC.)] Press Release
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POLICY NEWSMajor Funders Launch International Repository of Cutting-Edge Cancer Models U.S. and European funding agencies are launching the Human Cancer Models Initiative, which aims to give the research community tumor cells that behave more like actual human tumors. [ScienceInsider] Editorial
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EVENTSNEW European Society for Medical Oncology (ESMO) 2016 Visit our events page to see a complete list of events in the endothelial cell community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Vascular Biology (Boston Children’s Hospital) NEW Postdoctoral Fellow – Vascular Cell Signaling (LSU Health Science Center) NEW Postdoctoral Positions – Endothelial Cells (Instituto de Medicina Molecular) Faculty Position – Liver Regeneration (University of Poitiers) Postdoctoral Fellow – Immunometabolism (Dalhousie University) Postdoctoral Position – Endothelial Cells (KULeuven) PhD Student – Endothelial Responses to Stiffening in Aging Blood Vessels (AMC Medical Research) Postdoctoral Scientist – Decoding New Targets in Angiogenesis (VIB) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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