Endothelial Cell News 1.27 October 3, 2016 | |
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TOP STORYAngiotensin Receptors and β-Catenin Regulate Brain Endothelial Integrity in Malaria Scientists demonstrated that ruptured Plasmodium falciparum–infected red blood cells induce activation of β-catenin, leading to disruption of inter–endothelial cell junctions in human brain microvascular endothelial cells. [J Clin Invest] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)A macrocyclic ruthenium(III) complex [RuIII(N2O2)Cl2]Cl is reported as an inhibitor of angiogenesis and an anti-tumor compound. The complex is relatively non-cytotoxic towards endothelial and cancer cell lines in vitro, but specifically inhibited the processes of angiogenic endothelial cell tube formation and cancer cell invasion. [Angew Chem Int Ed] Abstract Flow-Dependent YAP/TAZ Activities Regulate Endothelial Phenotypes and Atherosclerosis The authors investigated the functional role of Yes-associated protein (YAP)/transcriptional coactivator with PDZ-binding motif (TAZ) in the flow regulation of atheroprone endothelial phenotypes and the consequential development of atherosclerotic lesions. [Proc Natl Acad Sci USA] Abstract Researchers demonstrated that thrombin triggers MALT1 to proteolytically cleave cylindromatosis (CYLD). Fragmentation of CYLD results in microtubule disruption and a cascade of events leading to endothelial cell retraction and an acute permeability response. [Cell Rep] Full Article | Graphical Abstract Scientists developed a method to culture monolayer human embryonic stem cells (hESCs) on stem cell niche laminin LN511 or LN521 matrix. They report a chemically defined, xeno-free protocol for differentiation of hESCs to endothelial progenitor cells using LN521 as the main culture substrate. [Stem Cell Reports] Full Article Endothelial Cells Require CD98 for Efficient Angiogenesis The authors used specific genetic targeting and antibody blockade approaches to examine the function of CD98 in endothelial cell proliferation, blood vessel growth, and tumor angiogenesis. [Arterioscler Thromb Vasc Biol] Abstract Investigators explored the ability of perfused cells to form new vessels. In the absence of exogenous angiogenic stimuli, Dll4, a marker of endothelial capillary-tip cell activation during sprouting angiogenesis was absent, indicating the reformed vasculature was largely quiescent. However, after addition of VEGFA, Dll4 positive endothelial cells could be detected, demonstrating this engineered vascular construct maintained its capacity for neovascularization. [Tissue Eng Part A] Abstract HIF-1α induced by hypoxia and CoCl2 up-regulated vascular endothelial growth factor and miR-21, and increased angiogenesis. It was found that expression of target gene thrombospondin 1 (TSP-1) was inversely related with miR-21 in vitro and in vivo. [Transplantation] Abstract Scientists found that protein levels of VEGFA and cyclin D1 were regulated by the JAK/STAT3 pathway, and flow cytometry further confirmed variations in cell cycle parameters of endothelial cells and adipose-derived stromal cells. [Cell Prolif] Abstract Compared with hematopoietic stem cell transplantation, endothelial progenitor cells infusion promoted the differentiation and reduced apoptosis of transplanted hematopoietic stem cells, possibly through promotion of vascular repair of the bone marrow microenvironment via differentiation into the bone marrow endothelial cells. [Ann Hematol] Abstract Researchers investigated how high glucose (HG) and advanced glycation end products (AGEs) regulate miR-126 expression and whether miR-126 mediates the effects of HG and AGEs on endothelial progenitor cells. [J Vasc Res] Abstract | |
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REVIEWSEndothelial Cell Senescence and Thrombosis: Aging Clots The authors present and discuss important findings regarding the effects of the cardiovascular risk factor age on endothelial cell morphology and function including the senescence-associated secretory phenotype and altered expression of factors involved in thrombosis and fibrinolysis. [Thromb Res] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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SCIENCE NEWSEisai Inc. announced the presentation of seven abstracts featuring data on its cancer treatments. The abstracts highlight new results for the company’s oncology agents, Halaven® and Lenvima®, for investigational uses in difficult-to-treat cancers and provide new information about these agents across multiple tumor types. [Press release from Eisai Inc. (PR Newswire Association LLC.) discussing research to be presented at the European Society of Medical Oncology (ESMO) 2016 Congress, Copenhagen] Press Release | |
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INDUSTRY NEWSMedicine Nobel for Research on How Cells ‘Eat Themselves’ Molecular biologist Yoshinori Ohsumi has won the 2016 Nobel Prize in Physiology or Medicine for his work in the field of autophagy: the processes by which the cell digests and recycles its own components. [Nature News] Editorial | Press Release X4 Pharmaceuticals announced dosing of the first patient in its Phase Ib study of X4P-001 in patients with resectable Stage III and Stage IV melanoma. [X4 Pharmaceuticals] Press Release Allegro Ophthalmics, LLC. announced completion of enrollment in its PACIFIC Phase IIb clinical trial that is evaluating the safety and efficacy of Luminate® in inducing posterior vitreous detachment in patients with non-proliferative diabetic retinopathy. [Allegro Ophthalmics, LLC.] Press Release | |
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POLICY NEWSDemocratic Databases: Science on GitHub Scientists are turning to a software–development site to share data and code. [Nature Toolbox] Editorial Biologists Plan Scoring System for Antibodies Biomedical experts plan to create a scoring system that will help researchers choose reliable antibodies for their experiments. The only problems: figuring out how such a ranking would work — and getting manufacturers to adopt the standard. [Nature News] Editorial UK Bioethicists Eye Designer Babies and CRISPR Cows From designer babies to engineered mosquitoes, advances in genome-editing technologies such as CRISPR–Cas9 have raised the possibility of tremendous scientific advances — and serious ethical concerns. [Nature News] Editorial
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EVENTSNEW Advances in Cell Engineering, Imaging and Screening NEW Challenges, Solutions and Progress in Stem Cell Medicine Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Positions – Cell Biology (The Roskamp Institute, Inc.) NEW Postdoctoral Scientist – Mitochondrial Signaling in Angiogenesis (VIB) NEW Faculty Position – Tumor Immunology (Vanderbilt University Medical Center) NEW Postdoctoral Associate – Cancer Research (Thomas Jefferson University) Postdoctoral Research Fellow (University of Leeds) Postdoctoral Fellow – Extracellular Vesicle (Exosome) Research in Cancer) PhD Position – Blood-Saliva Barrier (Austrian Institute of Technology) Chair – Medical Biology (Masaryk University) PhD Thesis – In Vitro Models of the Blood-Saliva Barrier (Austrian Institute of Technology GmbH) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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