Endothelial Cell News 1.29 October 24, 2016 | |
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TOP STORYAtorvastatin Enhances Endothelial Cell Function in Post Transplant Poor Graft Function Researchers evaluated the function of bone marrow endothelial progenitor cells (BM EPCs) in subjects with poor graft function (PGF) post-allotransplant. Moreover, they investigated whether atorvastatin could enhance the number and function of BM EPCs derived from subjects with PGF in vitro. [Blood] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Investigators showed that miR302-367 elevation in endothelial cells reduces retinal sprouting angiogenesis and promotes vascular stability in vivo, ex vivo and in vitro. Erk1/2 is identified as direct target of miR302-367, and down-regulation of Erk1/2 upon miR302-367 elevation in endothelial cells increases the expression of Klf2 and in turn S1pr1 and its downstream target VE-cadherin, suppressing angiogenesis and improving vascular stability. [Circ Res] Abstract Aberrant ceRNA-Mediated Regulation of KNG1 Contributes to Glioblastoma-Induced Angiogenesis The siRNA-mediated knockdown of CTU1, KIAA1274, or RAX in U87 cells and immortalized human endothelial cells (iHECs) significantly reduced KNG1 expression, which resulted in the upregulation of oncogenic EGFR signaling in both cell lines, and stimulated angiogenic processes in cultured iHECs and zebrafish and mouse xenograft models of glioblastoma-induced angiogenesis. [Oncotarget] Full Article In human umbilical vein endothelial cells, eriocalyxin B treatment could significantly block vascular endothelial growth factors (VEGF)-induced cell proliferation, tube formation, cell migration and cell invasion. [Oncotarget] Full Article Acetylcholine Released by Endothelial Cells Facilitates Flow-Mediated Dilatation Scientists showed acetylcholine is an autocrine signaling molecule released from endothelial cells, and identified a new role for the classical neurotransmitter in endothelial mechanotransduction. [J Physiol] Abstract | Full Article Dermal-Epidermal Cross-Talk: Differential Interactions with Microvascular Endothelial Cells Scientists report that human dermal fibroblasts (NHDF) promote viability and proliferation of microvascular endothelial cells (HMVEC), while HMVEC are not mitogenic for NHDF. [J Cell Physiol] Abstract Researchers found that STPC2 significantly inhibited endothelial cell migration and tube formation without toxicity. STPC2 reduced the mRNA and protein expression of vascular endothelial growth factor-A (VEGF-A) and hypoxia-inducible factor (HIF)-1 alpha in the endothelial cells. [Int J Biol Macromol] Abstract Researchers explored the effect of aptamers on intracellular plasminogen activator inhibitor-1 (PAI-1). They transiently transfected the PAI-1 specific aptamers into both MDA-MB-231 human breast cancer cells, and human umbilical vein endothelial cells and studied their effects on cell migration, invasion and angiogenesis. [PLoS One] Full Article The authors examined the effects of paeonol on microRNA-126 expression, and its ability to inhibit monocyte adhesion to oxidized low-density lipoprotein (ox-LDL)-injured vascular endothelial cells. [Int J Mol Med] Abstract Scientists investigated how high-intensity interval and moderate-intensity continuous exercise training affect circulating monocyte-derived endothelial progenitor cells (EPCs) levels and EPC functionality under hypoxic condition. [Eur J Appl Physiol] Abstract | |
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REVIEWSVascular Adaptation in Pregnancy and Endothelial Dysfunction in Preeclampsia The authors review the endocrinology of maternal adaptation to pregnancy and contrast this with that of preeclampsia (PE). Their focus was specifically on those hormones with directly impact endothelial cell function and dysfunction, as endothelial cell dysfunction is a hallmark of PE. [J Endocrinol] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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INDUSTRY NEWSAllegro Ophthalmics, LLC announced that the DEL MAR Phase IIb clinical trial evaluating Luminate® in 136 patients with diabetic macular edema met its primary and secondary endpoints, demonstrating promising visual acuity gains and reduction in central macular thickness that were equivalent to bevacizumab monotherapy. [Allegro Ophthalmics, LLC] Press Release Ocular Therapeutix, Inc. provided an update on the company’s development strategy for its sustained release intravitreal depot technology for the treatment of serious retinal diseases. [Ocular Therapeutix, Inc.] Press Release | |
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POLICY NEWSReview Finds Misconduct in Events Surrounding WHO Fetal Growth Study For the first time in its 68-year history, the World Health Organization (WHO) has concluded that researchers are guilty of research misconduct. An independent review commissioned by WHO has found that “research ethics misconduct occurred” in a multimillion-dollar global study on fetal growth led by researchers at the University of Oxford in the United Kingdom. [ScienceInsider] Editorial Two Major California Research Institutes Will Merge One of the biggest nonprofit biomedical research outfits in the world is getting a new translational medicine research arm, aimed at speeding the conversion of basic research insights into novel medicines. Officials at the Scripps Research Institute announced that it will merge with the California Institute for Biomedical Research, which was launched in 2012 as a nonprofit version of a drug development company. [ScienceInsider] Editorial To Save Money, NSF Requires University Cost-Sharing for Rotators The National Science Foundation (NSF) has decided that universities should pay 10% of the salaries of faculty members working temporarily at the agency. NSF hopes the new policy will demonstrate its commitment to saving taxpayer dollars without alienating the academic community that it relies upon to stay on the cutting edge of basic science. [ScienceInsider] Editorial
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EVENTSNEW 29th Lorne Cancer Conference Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Fellow – Vascular Regeneration and Angiogenesis (University of Edinburgh) Postdoctoral Research Associate – Cancer Research (Weill Cornell College of Medicine) Postdoctoral Positions – Vascular and Immune Modulation in Cancer (VIB) Postdoctoral Positions – Cell Biology (The Roskamp Institute, Inc.) Faculty Position – Tumor Immunology (Vanderbilt University Medical Center) Postdoctoral Associate – Cancer Research (Thomas Jefferson University) Postdoctoral Fellow – Extracellular Vesicle [Exosome] Research in Cancer (McGill University) Chair – Medical Biology (Masaryk University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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