Endothelial Cell News 2.32 September 25, 2017 | |
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TOP STORYResearchers showed that the adenosine A2a receptor promotes hypoxia-inducible transcription factor-1-dependent endothelial cell glycolysis, which is crucial for pathological angiogenesis in proliferative retinopathies. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Cepharanthine inhibited the endolysosomal trafficking of free-cholesterol and low-density lipoprotein in HUVECs by binding to Niemann-Pick disease, type C1 protein and increasing the lysosomal pH. The blockade of cholesterol trafficking led to a cholesterol-dependent dissociation of mTOR from the lysosomes and inhibition of its downstream signaling. [Cancer Lett] Abstract ANGPTL4 Mediates the Protective Role of PPARγ Activators in the Pathogenesis of Preeclampsia The authors showed that peroxisome proliferator-activated receptor γ (PPARγ) agonist rosiglitazone upregulated the expression and secretion of angiopoietin-like protein 4 (ANGPTL4) in a dose-dependent manner in HTR8/SVneo cells, HUVECS and placental explants. [Cell Death Dis] Full Article Researchers investigated the role of sirtuin 3 (SIRT3) on endothelial cell (EC) glycolytic metabolism, angiogenesis, and diastolic function. They tested the hypothesis that loss of SIRT3 in ECs impairs endothelial glycolytic metabolism and angiogenesis and contributes to myocardial capillary rarefaction and the development of diastolic dysfunction. [J Mol Cell Cardiol] Abstract Human retinal endothelial cells treated with and without different concentrations of homocysteine showed a reduction of tight junction protein expression, increased FITC dextran leakage, decreased transcellular electrical resistance and increased angiogenic potential. [Sci Rep] Full Article Proteomic Response of Human Umbilical Vein Endothelial Cells to Histamine Stimulation Endothelial cells were treated with histamine, as the endogenous ligand of histamine receptors, to obtain a global overview of its cellular effects. [Proteomics] Abstract Researchers investigated the effects of different concentrations of propofol on cell damage, metabolic activity, barrier function and wound healing capacity of human endothelial cells. [Eur J Anaesthesiol] Abstract Adiponectin Modulates the Function of Endothelial Progenitor Cells via AMPK/eNOS Signaling Pathway Investigators transferred adiponectin gene into endothelial progenitor cells via lentiviral vectors and investigated the proliferation, migration and tube formation of these transfected cells. They found that adiponectin is highly expressed in endothelial progenitor cells and promotes their proliferation, migration and tube formation. [Biochem Biophys Res Commun] Abstract | |
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REVIEWSThe authors update current understandings of vascular endothelial growth factor inhibitors on cardiovascular toxicity, explore potential mechanisms, and clarify whether genetic or ethnic factors contribute to their adverse effects. [Ann Med] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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INDUSTRY NEWSAplagon Oy and Cadila Pharmaceuticals Sweden AB announced a development and commercialization agreement for Aplagon’s lead APAC product. APACs are proprietary, locally acting, potent antithrombotic products, which target blood vessel wall injury. [Aplagon Oy] Press Release Ophthotech Provides Update on Zimura® Complement Programs for Treatment of Eye Diseases Ophthotech Corporation announced the initiation of an open-label Phase IIa clinical trial of Zimura®, the company’s complement factor C5 inhibitor, in patients with wet age-related macular degeneration. [Ophthotech Corporation] Press Release | |
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POLICY NEWSWhat Germany’s Election Results Mean for Science As Germany reels from an unexpected surge for the far right in the elections, researchers don’t expect much effect on the country’s generous support for science. But with smaller parties standing to gain political influence, battles over issues such as the regulation of gene-edited organisms and how to cut greenhouse-gas emissions could grow fiercer. [Nature News] Editorial BIA & MHRA Publish Report ‘Innovation in Life Sciences in a Changing and Dynamic Environment’ The UK BioIndustry Association (BIA) and the Medicines and Healthcare Products Regulatory Agency (MHRA) brought together experts from across the sector to discuss some hot topics and important developments that are having an impact on the changing and dynamic UK life sciences ecosystem. [Medicines and Healthcare Products Regulatory Agency] Press Release United Kingdom Sees Dip in European Research Applications after Brexit Vote The number of researchers applying for Europe-funded Marie Curie fellowships in the United Kingdom has dipped slightly since the country’s vote to leave the European Union, data released to Nature show. But there is no evidence yet of a sharp collapse in interest, which some scientists had feared in the wake of the Brexit referendum. [Nature News] Editorial HHMI’s Own Brand of Diversity in the Life Sciences One of Erin O’Shea’s first moves as Howard Hughes Medical Institute (HHMI) president was committing $25 million a year to support postdocs from underrepresented groups. Her hope was that they would eventually change the color—and culture—of their departments as they moved into leadership positions, in addition to serving as role models for the next generation of scientists. [ScienceInsider] Editorial
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EVENTSNEW 22nd International Workshop of the International Society for the Study of Vascular Anomalies Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Research Fellow – Cerebral Small Vessel Disease (University of Edinburgh) Postdoctoral Fellow – Tumor and Vascular Biology (Karolinska Institutet) Postdoctoral Fellow – Inflammation and Endothelial Cell Biology (University of Gothenburg) Postdoctoral Fellow – Vascular Cell Signaling (Louisiana State University Health Sciences Center) Postdoctoral Position – Vascular Biology Relating to Cardiovascular Diseases (University of Hawaii) Postdoctoral Position – Biology of Blood Platelets (INSERM) Assistant Professor – Stem Cell and Regenerative Medicine (Harvard University) Postdoctoral Research Scientist – Tissue Repair (The University of Alabama) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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