Endothelial Cell News 2.35 October 23, 2017 | |
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TOP STORYStudy Shows How Nerves Drive Prostate Cancer Researchers at Albert Einstein College of Medicine report that certain nerves sustain prostate cancer growth by triggering a switch that causes tumor vessels to proliferate. [Press release from Albert Einstein College of Medicine discussing online prepublication in Science] Press Release | Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Hdac3 Regulates Lymphovenous and Lymphatic Valve Formation The authors showed that during mouse development, the histone-modifying enzyme histone deacetylase 3 (Hdac3) regulates the formation of both lymphovenous valves, which maintain the separation of the blood and lymphatic vascular systems, and the lymphatic valves. [J Clin Invest] Full Article Investigators describe how the endothelial transcription factor ETS-related gene (ERG) promotes liver homoeostasis by controlling canonical transforming growth factor β (TGFβ)-SMAD signaling, driving the SMAD1 pathway while repressing SMAD3 activity. Molecular analysis showed that ERG binds to SMAD3, restricting its access to DNA. [Nat Commun] Full Article | Press Release Scientists linked matricellular protein thrombospondin 1 (TSP1) and its receptor CD47 to the activation of NADPH oxidase 1 (Nox1), but not of the other closely related Nox isoforms, and associated oxidative stress, and to senescence in human cells and aged tissue. In human endothelial cells, TSP1 promoted senescence and attenuated cell cycle progression and proliferation. [Sci Signal] Abstract Researchers used an in vitro model to assess monocyte binding to HLA I Ab-activated endothelial cells and found mechanistic target of rapamycin (mTOR) inhibition reduced ezrin/radixin/moesin phosphorylation, ICAM-1 clustering and monocyte firm adhesion to HLA I Ab-activated endothelium. [Am J Transplant] Abstract The authors explored the role of Nogo-B in the regulation of angiogenesis in proliferative diabetic retinopathy (PDR) patients and primary human retinal endothelial cells (HRMECs). Nogo-B was highly enriched in ocular tissues of PDR patients and in HRMECs exposed to high glucose. [Cell Physiol Biochem] Full Article Investigators examined the pro-angiogenic effects of cathepsin D (CathD) in human omental microvascular endothelial cells i.e. proliferation and migration, to investigate whether these effects are dependent on CathD catalytic activity and to delineate the intracellular signalling kinases activated by CathD. [Biochim Biophys Acta] Full Article The authors co-cultured human skin-derived precursors with B4G12 cells in serum-free medium and obtained abundant corneal endothelial cell (CEC)-like cells which had similar morphology and characteristics to human CECs. CEC-like cells exerted excellent therapeutic effect when they were transplanted into rabbit and monkey corneal endothelial dysfunction models by injection method. [Sci Rep] Full Article Scientists established a NaAsO2-induced sinusoidal dedifferentiation mice model. Liver sinusoidal endothelial cells (LSECs) were isolated and isobaric tag for relative and absolute quantitation based proteomic approach was adopted to globally examine the effects of arsenic on LSECs during the progression of sinusoidal dedifferentiation. [Sci Rep] Full Article | |
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REVIEWSTissue Regeneration Using Endothelial Colony-Forming Cells: Promising Cells for Vascular Repair The authors provide a brief overview of human endothelial colony-forming cell (ECFC) isolation and characterization, a survey of a number of animal models of human disease in which ECFCs have been shown to have prominent roles in tissue repair, and a summary of current challenges that must be overcome before moving ECFCs into human subjects as a cell therapy. [Pediatr Res] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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SCIENCE NEWSInSphero to Present Novel 3D Human Liver Fibrosis Model InSphero AG presented data characterizing and demonstrating the utility of its new 3D InSight™ Human Liver Fibrosis Model for screening efficacy of anti-fibrotic drugs. [Press release from InSphero AG discussing research presented at The Liver Meeting® 2017, the Annual Meeting of the American Association for the Study of Liver Diseases (AASLD), Washington, D.C.] Press Release | |
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INDUSTRY NEWSNew Target Emerging for Treating Diabetes-Related Blood Vessel Damage A key enzyme that helps our proteins fold and function properly may also be a good therapeutic target to improve blood vessel health in diseases like diabetes and atherosclerosis, scientists say. Ushio-Fukai is principal investigator on a new $1.4 million grant from the National Institutes of Health to further nail down the target and move toward “therapeutic” angiogenesis. [Augusta University] Press Release VBL Therapeutics Announces Orphan Drug Designation for VB-111 in Europe VBL Therapeutics announced that the European Medicines Agency has designated ofranergene obadenovec (VB-111) as an “orphan medicinal product” for the treatment of ovarian cancer, adding to the orphan status already granted for glioblastoma in US and Europe. [VBL Therapeutics] Press Release | |
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POLICY NEWSIranian Scholar Sentenced to Death A judge in Tehran has ordered the death penalty for Iranian researcher Ahmadreza Djalali, according to his wife and diplomatic sources in Italy. Djalali is affiliated with the Karolinska Institute in Stockholm, Sweden, and the University of Eastern Piedmont in Novara, Italy. A resident of Sweden with his family, Djalali was arrested in April 2016 on an academic visit to Tehran and accused of “collaboration with a hostile government”. [Nature News] Editorial In Brazil, Researchers Struggle to Fend Off Deepening Budget Cuts With time and money running out, Brazilian scientists are turning up the pressure on the federal government to avoid a total collapse of the national science and technology funding system before the end of the year. Researchers delivered a petition with more than 82,000 signatures to congressional leaders in Brasília, demanding the reversal of deep budget cuts that have left research institutions struggling to pay even basic water and electricity bills. [ScienceInsider] Editorial
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EVENTSNEW International Society on Thrombosis and Hemostasis Scientific and Standardization Committee (ISTH SSC) 2018 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Research Assistant – Bone and Vascular Biology (University of Oxford) NEW PhD Studentship – Cardiovascular Research (Max Planck Institute for Heart and Lung Research) Postdoctoral Position – Basic Neuroscience (McLean Hospital/Harvard Medical School) PhD Student – Cystic Fibrosis Associated Liver Disease (KU Leuven) Scientist – Angiogenesis (University of East Anglia) Postdoctoral Fellowship – Pulmonary Vascular Biology (Stanford University) Postdoctoral Position – Tumor Immunology and Cancer Immunotherapy (VIB) Postdoctoral Fellow – Tumor and Vascular Biology (Karolinska Institutet) Postdoctoral Position – Biology of Blood Platelets (INSERM) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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