Endothelial Cell News 3.01 January 15, 2018 | |
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TOP STORYDietary Salt Promotes Neurovascular and Cognitive Dysfunction through a Gut-Initiated TH17 Response Researchers report that, in mice, excess dietary salt suppresses resting cerebral blood flow and endothelial function, leading to cognitive impairment. The effect depends on expansion of TH17 cells in the small intestine, resulting in a marked increase in plasma interleukin-17. [Nat Neurosci] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)The authors showed that caudal vein of the embryonic zebrafish can be used as a model for assessing nanoparticle interactions with mammalian liver sinusoidal endothelial cells and macrophages. [ACS Nano] Abstract Researchers showed that cavin-1, a component of caveolae, is a functionally significant suppressor of cytokine signaling 3 (SOCS3)-interacting protein. SOCS3 was critical for cavin-1 stabilization, such that deletion of SOCS3 reduced the expression of cavin-1 and caveolin-1 proteins, thereby reducing caveola abundance in endothelial cells. [Nat Commun] Full Article Scientists found that two transcription factors, MYCN and SOX17, induce and indefinitely expand in culture precursors of human arterial endothelial cells (expandable arterial endothelial precursors [eAEPs]). Independent eAEP lines differred in their proclivity to undergo an endothelial-to-mesenchymal transition, a hallmark event in a broad array of vascular diseases and disorders. [Stem Cell Reports] Full Article | Press Release Cardiac Endothelial Cell Transcriptome Researchers applied fluorescence-assisted cell sorting to isolate pure endothelial cells (ECs) from adult mouse hearts. RNAseq revealed 1288 genes predominantly expressed in cardiac ECs versus heart tissue including several transcription factors. [Arterioscler Thromb Vasc Biol] Abstract Investigators demonstrated the considerable remodeling potential of spinal cord blood vessels and highlighted an important angiogenic role for the α5β1 integrin in promoting endothelial proliferation. [Angiogenesis] Abstract Scientists evaluated the effects of Slit2/Robo1 signaling pathway on angiogenesis of human renal glomerular endothelial cells exposed to a diabetic-like environment or recombinant Slit2-N. [Angiogenesis] Abstract Angiopoietins Bind Thrombomodulin and Inhibit Its Function as a Thrombin Cofactor Angiopoietin-1 and angiopoietin-2 inhibited the thrombin/thrombomodulin (TM)-mediated generation of activated protein C and thrombin-activatable fibrinolysis inhibitor in cultured endothelial cells, and inhibited the binding of thrombin to TM in vitro. [Sci Rep] Full Article Xeno-Free Pre-Vascularized Spheroids for Therapeutic Applications Investigators developed axeno-free supplement for cell culture-based formulation for 2D-culture of outgrowth endothelial cells (OEC), and then used it for generating co-culture spheroids of OEC and mesenchymal stem cells. [Sci Rep] Full Article Investigation of Quercetin and Hyperoside as Senolytics in Adult Human Endothelial Cells Given quercetin’s narrow therapeutic index reported in work done with human umbilical vein endothelial cells (HUVECs), the authors hypothesized that quercetin is not innocuous for non-senescent adult human vascular endothelial cells at concentrations that have been reported to be safe for proliferating HUVECs. [PLoS One] Full Article Production of BMP4 by Endothelial Cells Is Crucial for Endogenous Thymic Regeneration Scientists showed that thymic endothelial cells (ECs) comprise a critical pathway of regeneration via their production of bone morphogenetic protein 4 (BMP4). ECs increased their production of BMP4 after thymic damage, and abrogating BMP4 signaling or production by either pharmacologic or genetic inhibition impaired thymic repair. [Sci Immunol] Full Article | |
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REVIEWSThe Evolving Role of MicroRNAs in Endothelial Cell Dysfunction in Response to Infection The authors present the current state of knowledge regarding the role of microRNAs with emphasis on their role in controlling endothelial cell function. [Semin Thromb Hemost] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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INDUSTRY NEWSEisai Co., Ltd. and Merck announced that they received Breakthrough Therapy Designation from the FDA for Eisai’s multiple receptor tyrosine kinase inhibitor LENVIMA® in combination with Merck’s anti-PD-1 therapy KEYTRUDA® for the potential treatment of patients with advanced and/or metastatic renal cell carcinoma. [Merck] Press Release Molecular Partners AG announced initial safety and efficacy data from its ongoing phase II study of MP0250 in multiple myeloma. MP0250 is a proprietary DARPin® drug candidate neutralizing VEGF and HGF and thus blocking key escape pathways and resistance. [Molecular Partners AG] Press Release | |
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POLICY NEWSSouth Korean Universities Reach Agreement with Elsevier after Long Standoff After a months-long standoff, a consortium of hundreds of South Korean universities has reached a new deal with scientific publisher Elsevier for access to ScienceDirect, a database containing content from 3,500 academic journals and thousands of electronic books. [ScienceInsider] Editorial Rising Star Appointed UK Science Minister The United Kingdom has gained a new science minister as part of a broader reshuffle of government posts. Sam Gyimah, who moves from the Ministry of Justice, was appointed minister for universities and science, replacing Jo Johnson. [Nature News] Editorial
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EVENTSNEW The Stem Cell Niche Conference 2018 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Vascular Biology (City of Hope) NEW Research Faculty Position – Ophthalmology and Visual Science (Yale University) PhD Student – Hepatic Endothelial Cells (German Cancer Research Center) PhD Scholarship – Cardiovascular Science (Università degli Studi di Verona) PhD Positions – Angiogenesis and Vascular Metabolism (VIB) PhD Scholarships – Human Endothelial Cells in Chronic Disease (University of Hull) Postdoctoral Position – Cardiac Metabolism (University of British Columbia) Postdoctoral Position – Biology of Blood Platelets (INSERM) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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