Endothelial Cell News 3.04 February 5, 2018 | |
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TOP STORYNew Mouse Model Makes Stem Cells Light Up Green Multipotent stromal cells have long been a hot topic in medical research. Scientists have now found a way to specifically mark these stem cells. This makes it possible to analyze their distribution pattern and their function in living organisms. [Press release from the University of Bonn discussing online prepublication in Cell Stem Cell] Press Release | Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Researchers elucidated the potential role and molecular mechanism of circ-SHKBP1 in regulating the angiogenesis of U87 glioma-exposed endothelial cells (GECs). The expression of circ-SHKBP1, but not linear SHKBP1, was significantly upregulated in GECs compared with astrocyte-exposed endothelial cells. [Mol Ther Nucleic Acids] Full Article | Graphical Abstract Using a combination of loss of function studies in mouse and zebrafish as well as in vitro cell biology approaches, the authors identified a key role for Rasa3 in endothelial cells and vascular lumen integrity. [PLoS Genet] Full Article Scientists report that 48 hour clinorotation promoted cell migration in HUVECs by induction of autophagy. Furthermore, clinorotation enhanced autophagy by the mechanism of human murine double minute 2 (HDM2)-dependent degradation of cytoplasmic p53 at 26S proteasome, which resulted in the suppression of mechanistic target of rapamycin (mTOR), but not via activation of AMPK in HUVECs. [Cell Death Dis] Full Article Investigators examined the structure of clots formed on human umbilical vascular endothelial cells that had been treated with various types of particles versus those formed on untreated cells. There was a dose-dependent increase in fibre density in clots formed on particle-treated endothelial cells. [Thromb Haemost] Abstract By using various angiogenesis assays, it was delineated that DLK1 extracellular domain stimulated angiogenesis by promoting the proliferation, motility and tube formation of endothelial cells. [Angiogenesis] Abstract Scientists developed a renewable, scalable and transgene free human blood-brain barrier model, composed of brain endothelial cells, generated from human amniotic fluid derived induced pluripotent stem cells, which can also give rise to syngeneic neural cells of the neurovascular unit. [Sci Rep] Full Article Researchers showed that miR-146a and miR-181b impede the expression of E-selectin by repressing the activity of its transcription factor NF-κB, thereby impairing the metastatic potentials of colon cancer cells by decreasing their adhesion to, and migration through, the endothelium. [Sci Rep] Full Article Survivin Regulated by Autophagy Mediates Hyperglycemia-Induced Vascular Endothelial Cell Dysfunction Researchers found that high glucose did not cause endothelial injuries, instead, it evidently promoted endothelial proliferation and tube formation capacity indicating endothelial cell dysfunction upon hyperglycemia characterized by its preference to hyper-active status. [Exp Cell Res] Abstract | |
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REVIEWSIntegrated Approaches to Spatiotemporally Directing Angiogenesis in Host and Engineered Tissues Presenting angiogenic signals in a spatiotemporal fashion is beginning to generate improved vascular networks, which will allow for the creation of large and dense engineered tissues. Scientists provide a brief background on the cells, mechanisms, and molecules driving vascular development (including angiogenesis), followed by how biomaterials and growth factors can be used to direct vessel formation and maturation. [Acta Biomater] Abstract The authors discuss the potential role of humoral factors in triggering endothelial cell alterations in amyotrophic lateral sclerosis. A specific focus was on humoral IL-6 cytokine mediating EC inflammation via the trans-signaling pathway. [Int J Mol Sci] Full Article Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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INDUSTRY NEWSBracco Diagnostics Inc. announced that the labeling of its contrast agent MultiHance® has obtained FDA approval for an extension to include MRI of the CNS in pediatric patients younger than two years of age, to visualize lesions with abnormal blood-brain barrier or abnormal vascularity of the brain, spine, and associated tissues. [Bracco Diagnostics Inc.] Press Release PharmAbcine Inc. announced that it has entered into a collaborative agreement with MSD through a subsidiary, to evaluate PharmAbcine’s anti-VEGFR2 mAb, TTAC-0001, in combination with MSD’s anti-PD-1 therapy, KEYTRUDA®, in patients with recurrent glioblastoma multiforme and metastatic triple-negative breast cancer. [PharmAbcine Inc. (Business Wire (India) Inc.)] Press Release | |
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POLICY NEWSPubmed Commons Closes Its Doors to Comments The US National Institutes of Health announced that it will discontinue PubMed Commons, a tool that allows scientists to comment on articles indexed in the agency’s popular PubMed database of biomedical literature. The agency said low levels of engagement and the growth of alternate venues for public discussion of published papers contributed to its decision to close PubMed Commons after five years. [Nature News] Editorial Nature Journals Tighten Rules on Non-Financial Conflicts What makes a conflict of interest in science? Definitions differ, but broadly agree on one thing: an influence that can cloud a researcher’s objectivity. For some people, that influence can be money. But there are other influences that can interfere, such as institutional loyalty, personal beliefs and ambition. [Nature News] Editorial
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EVENTSNEW Stem Cells in Disease Modelling and Drug Discovery (SCDMDD) 2018 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW PhD Studentship – Tumor Biology (University College London) NEW Postdoctoral Fellow – Vascular Biology (Weill Cornell Medicine) Postdoctoral Position – Angiogenesis and Vessel Malformation (Karolinska Institutet) Postdoctoral Research Fellow – Therapeutic Angiogenesis (University of Michigan) Postdoctoral Fellow – Vascular Biology (City of Hope) Research Faculty Position – Ophthalmology and Visual Science (Yale University) PhD Positions – Angiogenesis and Vascular Metabolism (VIB) Postdoctoral Position – Biology of Blood Platelets (INSERM) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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