Endothelial Cell News 3.16 May 7, 2018 | |
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TOP STORYLymphatic Endothelial Cells Promote Melanoma to Spread Researchers found that growing human melanoma cells in co-cultures with human primary lymphatic endothelial cells revealed crosstalk of cancer cells with the tumor microenvironment leading to the increased invasive growth of melanoma cells and distant organ metastasis in a mouse tumor model. [Press release from the University of Helsinki discussing online prepublication in eLife] Press Release | Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Inactivation of the Serine Protease HTRA1 Inhibits Tumor Growth by Deregulating Angiogenesis Scientists report that silencing of HTRA1 in cultured endothelial cells increased migration rate and tube formation, whereas forced HTRA1 expression impaired sprouting angiogenesis. [Oncogene] Abstract The authors demonstrated a glycosylation-dependent regulatory mechanism for tumor angiogenesis. St6gal1−/− mice, lacking the α2,6-sialylation enzyme, were shown to exhibit impaired tumor angiogenesis through enhanced endothelial apoptosis. [Oncogene] Abstract GATA4 Regulates Angiogenesis and Persistence of Inflammation in Rheumatoid Arthritis Researchers demonstrated that GATA4 plays key roles in regulating VEGF secretion from rheumatoid arthritis fibroblast-like synoviocytes to promote cellular proliferation, induce cell migration, and angiogenic tube formation of endothelial cells. [Cell Death Dis] Full Article The nuclear factor-kappa-B (NFκB) pathway promotes vascular growth in the developing mouse lung, and investigators hypothesized that intrauterine growth restriction disrupts NFκB-regulated pro-angiogenic targets in fetal pulmonary artery endothelial cells. [Am J Physiol Lung Cell Mol Physiol] Abstract Researchers describe the construction of iEC2812, a genome scale metabolic reconstruction of endothelial cells and its application to describe metabolic changes that occur following endothelial dysfunction. [Sci Rep] Full Article ScFvs as Allosteric Inhibitors of VEGFR-2: Novel Tools to Harness VEGF Signaling Scientists investigated allosteric inhibition using binders targeting extracellular subdomains 4-7 of VEGFR-2 as an alternative to existing anti-angiogenic therapies, which rely on neutralizing VEGF or blocking of the ligand-binding site on the receptor. [Int J Mol Sci] Full Article Genetic Profiling of Young and Aged Endothelial Progenitor Cells in Hypoxia The authors identified 115 differentially expressed genes in young CD34+ endothelial progenitor cells (EPCs), 54 differentially expressed genes in aged CD34+ EPCs, and 25 common genes between normoxia and hypoxia groups. Among them, the expression of solute carrier family 2, member 1 increased the most by hypoxia in young cells. [PLoS One] Full Article Investigators verified the hypothesis that neuroligin 2, in parallel with its extraneuronal involvement in pancreatic beta cells exocytosis, modulated cytokine release from endothelial cells and consequently angiogenesis. [Biochem Biophys Res Commun] Abstract | |
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REVIEWSFetal Bovine Serum‐Free Culture of Endothelial Progenitor Cells – Progress and Challenges The authors provide a brief overview on the therapeutic relevance of endothelial progenitor cells, and critically analyze the available literature on fetal bovine serum‐free endothelial cell culture methods, including xeno‐free, serum‐free and chemically defined systems. [J Tissue Eng Regen Med] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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INDUSTRY NEWSVascugen Inc. announced that it has licensed a suite of intellectual property developed at the Indiana University (IU) School of Medicine related to blood vessel formation from adult stem cells. The regenerative medicine company is focused on finding therapies to repair tissues damaged by reduced blood flow due to disease or injury. [Vascugen Inc.] Press Release New Novartis Phase III Data for Brolucizumab Demonstrate Reliability of 12-Week Treatment Interval Novartis announced new positive brolucizumab data in neovascular age-related macular degeneration from a pre-specified secondary analysis of the Phase III HAWK and HARRIER trials. This is the first time a high level of reliability has been prospectively demonstrated for a pre-specified secondary endpoint of a 12-week dosing interval with an anti-VEGF therapy in Phase III trials. [Novartis] Press Release Ophthotech Corporation announced the completion of patient enrollment in its Phase IIa clinical trial of Zimura®, the company’s complement factor C5 inhibitor, in patients with wet age-related macular degeneration. [Ophthotech Corporation] Press Release Genentech announced that the FDA has accepted the company’s supplemental Biologics License Application and granted Priority Review for TECENTRIQ®, in combination with Avastin®, paclitaxel and carboplatin, for the initial treatment of people with metastatic non-squamous non-small cell lung cancer. [Genentech] Press Release | |
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POLICY NEWSBasic Scientists Still Feel Pinch of New NIH Clinical Trial Policy Basic researchers who study the brain and human behavior thought lawmakers had come to their rescue in March by blocking the National Institutes of Health (NIH) from redefining their studies as clinical trials. But NIH officials are still pushing ahead with new requirements that scientists say make no sense and will cripple their research. [ScienceInsider] Editorial Petition Asks National Academy of Sciences to Boot Sexual Harassers An online petition calling on the National Academy of Sciences to revoke memberships bestowed on people sanctioned for sexual harassment has garnered more than 250 signatures since it was posted on May 1. [The Scientist] Editorial Nature Announces New Editor-in-Chief Nature has named Magdalena Skipper as its new editor-in-chief. She is the first woman to hold the post. Skipper, who is currently editor-in-chief of the open-access journal Nature Communications, will become the eighth editor of Nature. [Nature News] Editorial Nature Journals Formalize Ethical Standards for Human Embryo and Stem-Cell Research Nature journals encourage stem-cell scientists to embrace guidelines agreed in 2016 by the International Society for Stem Cell Research as they design, execute and report their research. [Nature News] Editorial
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EVENTSNEW NAVBO: Vascular Biology 2018 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Technologist – Endothelial Cell Biology (STEMCELL Technologies Inc.) NEW Postdoctoral Research Scientist – Cardiovascular Regenerative Medicine (University of Oxford) NEW PhD Student – Hepatic Endothelial Cells (German Cancer Research Center) NEW Postdoctoral Fellow – Vascular Signaling of Cardiovascular Disease (AstraZeneca) NEW Postdoctoral Research Associate – Structural Biology (University of Oxford) NEW Postdoctoral Position – Stem Cells, Regenerative Biology (Helmholtz Zentrum München) Postdoctoral Fellows – Endothelial Cell Biology (KU Leuven) PhD Student – Hepatic Endothelial Cells (German Cancer Research Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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