Endothelial Cell News 3.32 September 24, 2018 | |
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TOP STORYThe conditioned medium of resveratrol-treated human umbilical cord-derived mesenchymal stem cells (Res-hucMSCs) accelerated the proliferation and migration of vascular endothelial cells in vitro and CD31 was in a high-level expression in Res-hucMSCs group in vivo. The angiogenesis was abrogated when Res-hucMSCs were treated with platelet-derived growth factor-DD siRNA. [Cell Death Dis] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scientists reported that basic fibroblast growth factor (FGF2)-Ras homolog gene family member A (RhoA)/Rho-associated protein kinase (ROCK) signaling functioned as a molecular switch to regulate the lineage fate of bone mesenchymal stem cells and that prevascularization promoted the cell fate switch, which contributed to increased bone regeneration with the use of prevascularized tissue-engineered bone grafts (TEBGs) compared with control TEBGs. [Cell Death Dis] Full Article Investigators cultured human peripheral blood mononuclear cells using a quality and quantity culture system under normal, microgravity (MG), or microgravity followed by normal (ME) conditions and found that ME resulted in the most significant increase in CD34+ and double positive Dil-Ac-LDL-FITC-Ulex-Lectin cells, both endothelial progenitor cell markers. [Sci Rep] Full Article Microgrooves in scaffolds were supposed to guide the assembly of HUVECs into well aligned tubular structures, thus promoting rapid angiogenesis. Subcutaneous implantation in mice showed that more blood vessels and newly formed bone were observed in the microgrooved composite scaffolds than in the control scaffold. [Sci Rep] Full Article Mesenchymal stem/stromal cells derived from chorionic villi of human term placenta reversed the effect of glucose on key endothelial cell functions including proliferation, migration, angiogenesis, and permeability. [Stem Cell Res Ther] Full Article Researchers demonstrated that platelet-derived growth factor (PDGF)-activated fibroblasts stimulated extracellular matrix fiber remodeling and deposition. The parallel-oriented fibers were used by endothelial cells as “tracks”, facilitating their activation and the creation of tubular structures mimicking in vivo capillary formation. [Oncogenesis] Full Article miR-665 Aggravates Heart Failure via Suppressing CD34-Mediated Coronary Microvessel Angiogenesis In vitro over-expression of miR-665 in endothelial cells resulted in decreased proliferation but enhanced apoptosis. CD34 was confirmed as one of the miR-665 targets. Consistently, re-expression of CD34 attenuated miR-665-mediated damage effects in vitro and in vivo. [Aging (Albany NY)] Full Article Inactivation of bone morphogenetic protein (BMP) receptor type II (BMPR2) in pulmonary vascular endothelial cells resulted in a deficit of RAD51, an enzyme essential for DNA repair and replication. Loss of RAD51, which caused DNA damage and cell death, was also detected in animal models and human patients with pulmonary arterial hypertension. Restoration of BMPR2 or activation of the BMP signaling pathway rescued RAD51 and prevented DNA damage. [Commun Biol] Full Article Scientists described an optimized three-dimensional co-culture protocol for the assessment of biological interactions between myogenic precursor cells and endothelial cells during skeletal muscle regeneration. [Methods Mol Biol] Abstract Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cell Therapy News. | |
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REVIEWSThe Role of Brain Vasculature in Neurodegenerative Disorders The authors examine the molecular definition of cerebral blood vessels, as well as pathways regulating cerebral blood flow and blood–brain barrier integrity. They also examine the role of cerebral blood flow and blood-brain barrier in the pathogenesis of Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and multiple sclerosis. [Nat Neurosci] Abstract Understanding Netrins and Semaphorins in Mature Endothelial Cell Biology Investigators review the current insights into the roles of netrins and semaphorins in endothelial cell survival, self-renewing, barrier function, response to wall shear stress, and control of the vascular tone. They also provide suggestions for future research into the functions of netrins and semaphorins in mature endothelial cell biology. [Pharmacol Res] Full Article | Graphical Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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SCIENCE NEWSNovartis announced a new data analysis showing that retinal fluid was detected less often in patients treated with brolucizumab (RTH258) 6 mg versus aflibercept over four visits between weeks 36 to 48. [Press release from Novartis International AG discussing research presented at EURETINA 2018, Vienna] Press Release | |
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INDUSTRY NEWSCase Western Reserve University School of Medicine has received a three-year, $1,118,556 grant from the National Heart, Lung, and Blood Institute of the National Institutes of Health (NIH) to investigate a new imaging approach for diagnosing peripheral arterial disease, a common and potentially serious circulatory problem. [Case Western Reserve University] Press Release Adverum Biotechnologies, Inc. announced the FDA has granted Fast Track designation for ADVM-022. ADVM-022 is a novel gene therapy candidate for the treatment of wet age-related macular degeneration (wAMD). [Adverum Biotechnologies, Inc.] Press Release Exelixis, Inc. announced that its partner Ipsen Biopharmaceuticals Canada Inc. received approval from Health Canada of CABOMETYX® tablets for the treatment of adults with advanced renal cell carcinoma who have received prior vascular endothelial growth factor targeted therapy. [Exelixis, Inc.] Press Release | |
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POLICY NEWSResearchers Take Action to End Airlines’ Restrictions on Lab Animals In a recently filed complaint to the US Department of Transportation, the National Association for Biomedical Research accused four major airlines of illegally discriminating against customers wishing to fly animals destined for the lab. [The Scientist] Editorial More and More Scientists Are Preregistering Their Studies. Should You? Preregistration, in its simplest form, is a one-page document answering basic questions such as: What question will be studied? What is the hypothesis? What data will be collected, and how will they be analyzed? In its most rigorous form, a “registered report,” researchers write an entire paper, minus the results and discussion, and submit it for peer review at a journal, which decides whether to accept it in principle. [ScienceInsider] Editorial
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EVENTSNEW 8th InterAmerican Oncology Conference Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Group Leader – In Vitro Vascular Systems (European Molecular Biology Laboratory) NEW Postdoctoral Fellow – Vascular and/or Lung Biology (Yale University) Postdoctoral Scientists – Vascular Diseases (Oklahoma Medical Research Foundation) Postdoctoral Scholar – Vascular Dysfunction in Sepsis (Medical University of South Carolina) Faculty Positions – Cardiovascular Research (Nationwide Children’s Hospital, Research Institute) Postdoctoral Fellow – Lymph Node Vasculature (Uppsala University) Scientist – Cardiovascular Research (University of Iowa Hospital and Clinics) Senior Postdoctoral Research Position – Cardiovascular Research (University of Tennessee) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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