Endothelial Cell News 3.33 October 1, 2018 | |
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TOP STORYElusive Stem Cells Could Help Repair Blood Vessels A unique source of stem cells in blood helps to build blood vessels according to new UCL-led research with mouse embryos. The findings change scientific understanding of how blood vessels are made and bring scientists one step closer to using stem cells to grow new blood vessels and repair damaged ones. [Press release from the University College London discussing online prepublication in Nature] Press Release | Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Mechanosensing by β1 Integrin Induces Angiocrine Signals for Liver Growth and Survival Scientists used the developing liver as a model organ to study angiocrine signals and showed that the growth rate of the liver correlated both spatially and temporally with blood perfusion to this organ. [Nature] Abstract | Editorial Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASM Researchers found that acid sphingomyelinase (ASM) was a critical factor for regulating brain endothelial barrier integrity. Genetic inhibition and endothelial-specific knockdown of ASM in mice ameliorated blood-brain barrier breakdown and neurocognitive impairment during aging. [Neuron] Abstract Sialylation of Vasorin by ST3Gal1 Facilitates TGF-β1 Mediated Tumor Angiogenesis and Progression ST3GAL1-silencing or desialylation of vasorin by neuraminidase enhanced its binding to TGF-β1 by two to three-fold and dampened TGF-β1 signaling and angiogenesis, as indicated by impaired tube formation of HUVECs, suppressed angiogenesis gene expression and reduced activation of Smad2 and Smad3 in HUVEC cells. [Int J Cancer] Abstract Investigators observed that CCL19 high-expressed SW1116 supernatant was able to inhibit proliferation, migration, and sprouting responses of HUVEC, whereas CCL19 low-expressed SW620 supernatant could promote HUVEC angiogenesis. [Cell Death Dis] Full Article FAK was highly expressed in HUVECs treated with estradiol (HU-ESTs). Cell viability and NO level decreased, whereas ROS level increased in the HU-ESTs. Inhibition of FAK greatly decreased cell invasion and migration. [Cell Physiol Biochem] Full Article Functionally, leukocytes were dispensable for the initial migratory response of a regrowing endothelial sheet, but critical for the subsequent formation and maintenance of a front zone with high cellular density. [J Leukoc Biol] Abstract The authors analyzed the angiogenic content of microparticles produced by activated platelets in subjects with Crohn’s disease. [Int J Mol Sci] Full Article Diversity in Human Placental Microvascular Endothelial Cells and Macrovascular Endothelial Cells To distinguish the differences between human placental microvascular endothelial cells (HPMECs) and HUVECs, investigators isolated HPMECs and HUVECs and validated their characteristics. [Cytokine] Abstract HADC Regulates the Diabetic Vascular Endothelial Dysfunction by Targetting MnSOD Researchers observed that histone deacetylase 2 (HDAC2) regulated the accumulation of reactive oxygen species induced by high glucose in vascular endothelial cells, which accounted for the effects of HDAC2 on proliferation and apoptosis. [Biosci Rep] Full Article Administration of T4 recombinant phages expressing the extracellular domain of VEGF receptor 2 (T4-VEGFR2) was able to suppress tumor growth and decrease microvascular density in murine models of Lewis lung carcinoma and colon carcinoma, and prolonged the survival of tumor bearing mice. [Arch Virol] Abstract Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cell Therapy News. | |
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REVIEWSEndothelial Cells: New Players in Obesity and Related Metabolic Disorders The authors summarize current views and discuss evidence in favor of a causal role for endothelial cells in systemic metabolic dysregulation. [Trends Endocrinol Metab] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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INDUSTRY NEWS$2.8 Million Federal Grant Awarded to TGen-UNM Consortium to Address Diabetic Blindness The National Institutes of Health has awarded a $2.8 million grant to the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, and to the University of New Mexico (UNM) in a groundbreaking effort to discover new treatments for diabetic blindness. [TGen] Press Release Weill Cornell Medicine Receives $2.7 Million Grant to Fund Diversity Center of Excellence Weill Cornell Medicine has been awarded a four-year, $2.7 million grant from the Health Resources and Services Administration to establish a Diversity Center of Excellence dedicated to increasing the number of minority physicians in academic medicine. [Weill Cornell Medicine] Press Release | |
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POLICY NEWSCancer Immunotherapy Pioneers Win Medicine Nobel Discoveries about ways to harness the immune system to attack cancer have won the 2018 Nobel Prize for Physiology or Medicine. [ScienceInsider] Editorial Tired of Male-Dominated Meetings, Leading Cancer Conference Makes Nearly All of Its Speakers Women Calling out “manels”—all male panels at meetings—has been one way researchers concerned about gender equity have called attention to the frequent imbalance of men and women on scientific conference programs. Now, organizers of a meeting at a leading cancer institute in Germany have gone a step further. At the Frontiers in Cancer Research meeting early next month, 23 of the 28 invited speakers—or 82%—are women. [ScienceInsider] Editorial Biologists Irate at NSF’s New One-Proposal Cap The National Science Foundation (NSF) in Alexandria, Virginia, has made several tweaks to its grant proposal policies in recent years to keep staff and reviewers from being overwhelmed by the rising number of submissions. But some biologists say the latest change goes too far. [ScienceInsider] Editorial
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EVENTSNEW NAVBO: Vascular Biology 2019 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Vascular Development (University of Colorado Denver) NEW Group Leader – Vascular Research (Helmholtz Zentrum München) Group Leader – In Vitro Vascular Systems (European Molecular Biology Laboratory) Postdoctoral Fellow – Vascular and/or Lung Biology (Yale University) Postdoctoral Scientists – Vascular Diseases (Oklahoma Medical Research Foundation) Postdoctoral Scholar – Vascular Dysfunction in Sepsis (Medical University of South Carolina) Faculty Positions – Cardiovascular Research (Nationwide Children’s Hospital, Research Institute) Postdoctoral Fellow – Lymph Node Vasculature (Uppsala University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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