Endothelial Cell News Volume 3.39 | Nov 26 2018

TOP STORY

Protocadherin-1 Is Essential for Cell Entry by New World Hantaviruses

Scientists identified the human asthma-associated gene protocadherin-1 (PCDH1) as an essential determinant of entry and infection in pulmonary endothelial cells by two hantaviruses that cause hantavirus pulmonary syndrome, Andes virus and Sin Nombre virus. [Nature] Abstract | Press Release | Press Release 2

(Ranked by impact factor of the journal)

N-Cadherin Signaling via Trio Assembles Adherens Junctions to Restrict Endothelial Permeability

Researchers demonstrated that deletion of N-cadherin in either endothelial cells or pericytes increased junctional endothelial permeability in lung and brain secondary to reduced accumulation of vascular endothelial-cadherin at adherens junctions. [J Cell Biol] Abstract

AAV2/8 Anti-Angiogenic Gene Therapy Using Single Chain Antibodies Inhibits Murine Choroidal Neovascularization

A therapeutic effect in a mouse model of choroidal neovascularization was demonstrated with antibodies in both scFv and immunoglobulin G1 formats. [Mol Ther Methods Clin Dev] Abstract | Full Article

TSPYL5-Mediated Inhibition of p53 Promotes Human Endothelial Cell Function

Investigators demonstrated that the expression of testis-specific protein, Y-encoded like (TSPYL) was highly enriched in human endothelial cells (ECs) such as HUVECs and human pluripotent stem cell-differentiated ECs. TSPYL5 overexpression was shown to promote EC proliferation and functions, such as migration and tube formation, by downregulating p53 expression. [Angiogenesis] Abstract

The Regulatory Network of miR-141 in the Inhibition of Angiogenesis

Researchers used several in vitro and in vivo models to demonstrate that miR-141 in endothelial cells inhibits angiogenesis. [Angiogenesis] Abstract

Galectin-3-Mediated Transdifferentiation of Pulmonary Artery Endothelial Cells Contributes to Hypoxic Pulmonary Vascular Remodeling

Galectin-3 (Gal-3) was found to inhibit cell proliferation and apoptosis in cultured endothelial cells. Meanwhile endothelial cell morphology was altered and exhibited smooth muscle-like cell features as demonstrated by the expression of α-SMA after Gal-3 treatment. [Cell Physiol Biochem] Full Article

Melatonin Protects Endothelial Progenitor Cells against Age-Induced Apoptosis via Autophagy Flux Stimulation and Promotes Wound Healing in Diabetic Mice

Scientists showed that melatonin protected endothelial progenitor cells against apoptosis and dysfunction via autophagy flux stimulation and ameliorated impaired wound healing in vivo. [Exp Mol Med] Full Article

MicroRNA Let‐7a Regulates Angiogenesis by Targeting TGFBR3 mRNA

Overexpression of let‐7a or knockdown of TGFBR3 in cell culture inhibited the tube formation and reduced migration rate. Moreover, xenograft experiments showed that overexpression of let‐7a or knockdown of TGFBR3 had smaller tumor size. [J Cell Mol Med] Full Article

Photobiomodulation (PBM) Promotes Angiogenesis In Vitro and in Chick Embryo Chorioallantoic Membrane Model

The authors investigated the potential effect of PBM from light emitting diodes at 635 nm, 80 mW/cm², 24 J/cm² on angiogenesis in a two-part study: 1.) Investigation of the effect of PBM on the proliferation of endothelial cells and on vasculogenesis in a co-culture model of endothelial cells and stem cells. 2.) Investigation of the influence of PBM at chick egg chorioallantoic membrane assays with fresh human skin xenografts. [Sci Rep] Full Article

Target Regulation of Both VECs and VSMCs by Dual‐Loading miRNA‐126 and miRNA‐145 in the Bilayered Electrospun Membrane for Small‐Diameter Vascular Regeneration

In vivo tests suggested that dual‐loading with miR‐126 and miR‐145 in the bilayered electrospun membranes could modulate both vascular endothelial cells (VECs) and vascular smooth muscle cells (VSMCs) for rapid endothelialization and hyperplasia inhibition. [J Biomed Mater Res A] Abstract

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Nano-Medicine and Vascular Endothelial Dysfunction: Options and Delivery Strategies

The authors reveal the various available, pipeline nano-medicine, their interaction with the endothelium and in other associated pathological conditions and their delivery strategies for target-specific treatment of vascular endothelial dysfunction. [Cardiovasc Toxicol] Abstract

Visit our reviews page to see a complete list of reviews in the endothelial cell research field.

TRACON Pharmaceuticals Presents New Circulating Tumor Cell Data from Ongoing Pivotal Phase III TAPPAS Trial of TRC105 and Votrient^® In Patients with Angiosarcoma

TRACON Pharmaceuticals presented new data from the company’s ongoing Phase III TAPPAS study of TRC105 and Votrient^® in patients with angiosarcoma. [Press release from TRACON Pharmaceuticals discussing research presented at the Connective Tissue Oncology Society (CTOS) Annual Meeting, Rome] Press Release

Chi-Med Announces First Commercial Launch of Fruquintinib Capsules (Elunate^®)

Hutchison China MediTech Limited (Chi-Med) announced the first commercial launch of fruquintinib capsules with the initiation of product sales in China. Fruquintinib is a small molecule, selective and highly potent inhibitor of VEGFR 1, 2 and 3. [Hutchison China MediTech Limited] Press Release

Opthea Confirms Final Patient Enrolment in Phase IIb Wet AMD Clinical Trial

Opthea Limited reported that the last patient has been enrolled in the company’s ongoing Phase IIb trial of OPT-302 for wet age-related macular degeneration and the final number of patients is confirmed as 366. OPT-302 is a soluble form of VEGFR-3 or ‘Trap’ molecule that blocks the activity of two proteins that cause blood vessels to grow and leak, processes which contribute to the pathophysiology of retinal diseases. [Opthea Limited (GlobeNewswire, Inc.)] Press Release

Crashing the Boards: Neuroscientist Maureen Condic Brings a Different Voice to NSF Oversight Body

The National Science Foundation (NSF) will welcome the first cohort of members appointed by President Donald Trump to its oversight body, the National Science Board. Most of the seven fit the mold of senior academic leaders, prominent scientists, and corporate research managers who typically sit on the 24-member board. But Maureen Condic is somewhat different. [ScienceInsider] Editorial

A 100^th Birthday Wish: Uphold Academic Freedom in Dark Times

One hundred years ago this month, shortly after the guns of the First World War fell silent, a German-speaking Scottish lawyer-turned-politician sent an 80-page report to his prime minister. In it was an idea whose echo still shapes the way in which many nations fund research — an idea arguably as important to the soul of modern science as the secular state is to modern democracy. [Nature News] Editorial

AI Peer Reviewers Unleashed to Ease Publishing Grind

A suite of automated tools is now available to assist with peer review but humans are still in the driver’s seat. A handful of academic publishers are piloting AI tools to do anything from selecting reviewers to checking statistics and summarizing a paper’s findings. [Nature News] Editorial

NEW Gordon Research Conference: Harnessing Lung Complexity Towards Improved Health Across the Lifespan
August 4-9, 2019
Lewiston, Maine, United States

Visit our events page to see a complete list of events in the community.

NEW Faculty Positions – Lung and Vascular Biology (Northwestern University)

Senior Research Assistant – Genitourinary Medical Oncology (MD Anderson Cancer Center)

Assistant/Associate Adjunct Professor – Cardiovascular Medicine (UC Davis)

Postdoctoral Positions – Angiogenesis and Vascular Metabolism (VIB)

Postdoctoral Research Associate – Endothelial Cell Research (University of Illinois)

Postdoctoral Positions – Cell/Developmental/Vascular Biology (Uppsala University)

Postdoctoral Fellow – Endothelial Cell Research (University of Missouri)

Postdoctoral Position – Molecular/Cell Biology of Neurodegeneration and Alzheimer’s Disease (Icahn School of Medicine at Mount Sinai)

Postdoctoral Fellow – Vascular Research (Johns Hopkins University School of Medicine)

Postdoctoral Fellow – Vascular Development (University of Colorado Denver)

Group Leader – Vascular Research (Helmholtz Zentrum München)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

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