Endothelial Cell News 3.41 December 10, 2018 | |
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TOP STORYScientists identified the endocytic receptor, uPARAP, as a partner of VEGFR-2 and VEGFR-3 that regulates their heterodimerisation. Genetic ablation of uPARAP led to hyperbranched lymphatic vasculatures in pathological conditions without affecting concomitant angiogenesis. In vitro, uPARAP controlled lymphatic endothelial cell migration in response to VEGF-C but not VEGF-A or VEGF-CCys156Ser. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Forkhead Box O1 (FoxO1) depletion increased endothelial proliferative and glycolytic capacities by upregulating the expression of glycolytic markers, which may account for the improvements at the tissue level ultimately impacting whole-body glucose metabolism. [Elife] Full Article | Press Release Using a novel simultaneous arterio‐venous delivery system, investigators report the complete re‐endothelialization of the kidney vasculature, including the glomerular and peritubular capillaries, using human induced pluripotent stem cell‐derived endothelial cells. [Am J Transplant] Abstract The authors analyzed the effects of textural parameters of biomimetic calcium deficient hydroxyapatite and sintered beta‐tricalcium phosphate, such as specific surface area, surface roughness, and microstructure, on the behavior of rat endothelial progenitor cells and their crosstalk with rat mesenchymal stem cells. [Adv Healthc Mater] Abstract Notoginsenoside R1 prevented ox-LDL-induced apoptosis, migration and adhesion-related molecule release in HUVECs possibly via down-regulating miR-132, and subsequent up-regulating matrix Gla protein. [Cell Physiol Biochem] Full Article Human Herpesvirus 6A and 6B Inhibit In Vitro Angiogenesis by Induction of Human Leukocyte Antigen G Virus-induced inhibition of endothelial cells (ECs) angiogenic ability directly correlated to HLA-G expression and release, and the addition of anti-HLA-G antibody restored the angiogenic properties of human herpesvirus 6-infected ECs. [Sci Rep] Full Article Extracellular Protein Fibulin-7 and Its C-Terminal Fragment Have In Vivo Antiangiogenic Activity Scientists examined the in vivo antiangiogenic activity of recombinant full-length fibulin-7 (Fbln7-FL) and Fbln7-C proteins using a rat corneal angiogenesis model. They found that both Fbln7-FL and Fbln7-C inhibited neovascularization. [Sci Rep] Full Article Using a chymase overexpression cell model, researchers investigated the mechanisms of chymase activation to test their hypothesis that histone acetylation could promote endothelial chymase expression. [Hypertens Res] Abstract Hsa‐miRNA‐29a Protects against High Glucose‐Induced Damage in Human Umbilical Vein Endothelial Cells The authors showed that hsa‐miRNA‐29a/Bcl‐2 associated X protein (Bax) played an essential role in the decreased proliferation and increased apoptosis of HUVECs induced by high glucose (HG), and overexpression of hsa‐miRNA‐29a effectively inhibited HG‐induced apoptosis and restored the proliferation and tube formation of HUVECs exposed to HG by inhibiting its target gene Bax. [J Cell Biochem] Abstract Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cell Therapy News. | |
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REVIEWSCytochrome p450 Epoxygenases and Cancer: A Genetic and a Molecular Perspective Researchers provide an overview of the role of CYP450 epoxygenase-derived lipids, with emphasis on arachidonic acid-derived products, in the regulation of endothelial cell function both in physiological and pathological conditions. [Pharmacol Ther] Abstract The Precise Molecular Signals That Control Endothelial Cell-Cell Adhesion within the Vessel Wall Investigators summarize the current knowledge of the mechanisms controlling endothelial cell-cell adhesion in the developing and mature blood vasculature. [Biochem Soc Trans] Full Article Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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INDUSTRY NEWSTens of thousands of lives could be saved by pioneering research to detect deadly diseases before symptoms even appear, thanks to a new collaboration between the government and the Life Sciences Industry. The deal will also announce that global biopharmaceutical company UCB is investing £1 billion in research and development, including in a new state-of-the-art facility, continuing the UK’s reputation as a world leading base for global life sciences research and industry. [GOV UK] Press Release Cerenis Therapeutics announced the results of TANGO, a Phase III clinical study evaluating CER-001 in patients with HDL deficiency. [Cerenis Therapeutics] Press Release | |
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POLICY NEWSSouth Africa’s Science Academy Urges Update to Nation’s Genetics Laws South Africa needs to overhaul the laws and ethical guidelines that govern its genetics research, testing and databases, says its national science academy — especially given the country’s troubled history of race-based discrimination. [Nature News] Editorial Despite Growing Budget, U.S. Cancer Institute Slashes Operating Budget by 5% A good year for biomedical research funding has turned sour at the National Cancer Institute (NCI) in Bethesda, Maryland, where the director is cutting operating budgets by 5% across the agency. Despite a rising overall budget, NCI’s funds are being stretched thin by various priorities and a ballooning number of funding applications, explains NCI Director Norman Sharpless. [ScienceInsider] Editorial Research Funders Make Secretive Overseas Investments: Report An investigation by Science reveals that charities’ investments support activities opposed to their own missions, such as human health and environmental protection. [The Scientist] Editorial China Backs Bold Plan to Tear Down Journal Paywalls In a huge boost to the open-access movement, librarians and funders in China have said that they intend to make results of publicly funded research free to read immediately on publication. The move includes a pledge of support for Plan S, a bold initiative launched in September by a group of European funders to ensure that, by 2020, their scientists make papers immediately open. [Nature News] Editorial
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EVENTSNEW 2019 ASCO Annual Meeting Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Zebrafish Vascular Biology (NYU Langone Medical Center) Postdoctoral Position – Molecular Neurobiology (San Raffaele Scientific Institute) Postdoctoral Position – Vascular Dementia (German Center for Neurodegenerative Diseases) Postdoctoral Fellow – Pulmonary Arterial Hypertension (National Institutes of Health) Faculty Positions – Lung and Vascular Biology (Northwestern University) Senior Research Assistant – Genitourinary Medical Oncology (MD Anderson Cancer Center) Assistant/Associate Adjunct Professor – Cardiovascular Medicine (UC Davis) Postdoctoral Positions – Angiogenesis and Vascular Metabolism (VIB) Postdoctoral Research Associate – Endothelial Cell Research (University of Illinois) Postdoctoral Positions – Cell/Developmental/Vascular Biology (Uppsala University) Postdoctoral Fellow – Endothelial Cell Research (University of Missouri) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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