Endothelial Cell News 4.27 August 12, 2019 | |
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TOP STORYResearchers found that placental growth factor, a homolog of the vascular endothelial growth factor that enhances an angiogenic switch in disease, was selectively secreted by the TH17 subset of helper T cells and promoted angiogenesis. [Nat Immunol] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scientists report the profiling of 33,000 lymphatic endothelial cells (LECs) in human lymph nodes by single-cell RNA sequencing. Unbiased clustering revealed six major types of human LECs. [Immunity] Abstract | Graphical Abstract CD146-HIF-1α Hypoxic Reprogramming Drives Vascular Remodeling and Pulmonary Arterial Hypertension CD146 was markedly upregulated in pulmonary artery smooth muscle cells (PASMCs) and in proportion to disease severity. CD146 expression and hypoxia-inducible transcription factor 1 alpha (HIF-1α) transcriptional program reinforced each other to physiologically enable PASMCs to adopt a more synthetic phenotype. [Nat Commun] Full Article Investigators describe a biomimetic approach where a supersaturated calcium and phosphate medium was used in combination with a non-collagenous protein analog to direct the deposition of nanoscale apatite, both in the intra- and extrafibrillar spaces of collagen embedded with osteoprogenitor, vascular, and neural cells. [Nat Commun] Full Article Treating Ischemia via Recruitment of Antigen-Specific T Cells Vaccinated mice receiving ovalbumin-releasing scaffolds locally concentrated antigen-specific TH2 T cells in surrounding ischemic tissue. This resulted in local angiogenesis, increased perfusion in ischemic limbs, and reduced necrosis and enhanced regenerating myofibers in muscle. [Sci Adv] Full Article | Press Release Whole-genome array from intense light-exposed wild-type or Period 2 (Per2-/-) mice and myocardial ischemia in endothelial-specific PER2-deficient mice uncovered a critical role for intense light in maintaining endothelial barrier function via light-enhanced hypoxia-inducible factor 1A transcription. [Cell Rep] Full Article | Graphical Abstract High lncRNA MALAT1 expression was detected in type 2 diabetes mellitus, and was positively correlated with HOMA-insulin resistance and resistin levels. Then, sh-MALAT1 or pcDNA-MALAT1 was delivered into HUVECs to knock down or up-regulate its expression, respectively. [Mol Ther Nucleic Acids] Abstract | Full Article Immortalized bronchial epithelial cells and umbilical vein endothelial cells were treated with acetylcholine in the presence of varying concentrations of tiotropium. Intracellular calcium concentration, extracellular regulated kinase phosphorylation and chemokine content in the conditioned media were assessed by commercial kits. [Sci Rep] Full Article VEGF Mediates Fat Embolism-Induced Acute Lung Injury via VEGF Receptor 2 and the MAPK Cascade Scientists found that animal oil-induced fat embolism (FE) significantly increased pulmonary VEGF expression and mitogen-activated protein kinase (MAPK) phosphorylation. They also evaluated the inflammatory response after FE and found that inducible nitric oxide synthase and interleukin-1β significantly increased after FE. [Sci Rep] Full Article Researchers isolated exosomes from the blood of non-small cell lung cancer (NSCLC) patients as well as NSCLC cell cultures, and assessed the impact of exosome exposure on the angiogenic capacities of HUVECs. [Mol Ther Oncolytics] Abstract | Full Article Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cell Therapy News. | |
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REVIEWSRole of miRNAs in Tumor and Endothelial Cell Interactions during Tumor Progression The authors focus on the role of miRNAs in endothelial cells regarding their positive or negative intervention on tumor angiogenesis or lymphoangiogenesis or when tumor cells detach from the tumor mass and intravasate or extravasation in/out of the blood vessels. [Semin Cancer Biol] Abstract The TGF-β1/p53/PAI-1 Signaling Axis in Vascular Senescence: Role of Caveolin-1 Plasminogen activator inhibitor-1 (PAI-1), a major TGF-β1/p53 target gene and negative regulator of the plasmin-based pericellular proteolytic cascade, is elevated in arterial plaques, vessel fibrosis, arteriosclerosis, and thrombosis, correlating with increased tissue TGF-β1 levels. The mechanism of PAI-1 transcription in senescent cells appears to be dependent on caveolin-1 signaling. [Biomolecules] Full Article Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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INDUSTRY NEWSOpthea Meets Primary Endpoint in Phase IIb Study of OPT-302 in Wet AMD Opthea Limited announced positive Phase IIb results demonstrating that OPT-302 combination therapy met the primary endpoint of superiority in mean visual acuity gain at 24 weeks compared to Lucentis® monotherapy in treatment-naïve patients with wet age-related macular degeneration (AMD). [Opthea Limited (GlobeNewswire, Inc.)] Press Release Opthea’s Patent Application Covering OPT-302 to be Granted by European Patent Office Opthea Limited announced that the European Patent Office (EPO) has issued a “Notice of Intention to Grant” in relation to Opthea’s European patent application covering OPT-302, a soluble form of VEGF Receptor-3 that binds and inhibits the activity of VEGF-C and VEGF-D. [Opthea Limited (GlobeNewswire, Inc.)] Press Release | |
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POLICY NEWSAcademia to FBI on Monitoring Chinese Scientists: “Tread Carefully” Nearly two dozen higher education groups warn the government to be cautious when advising US research universities to keep an eye on students and faculty with ties to certain Chinese institutions. [The Scientist] Editorial UK Announces Fast-Track Visa to Recruit Top Scientists British Prime Minister Boris Johnson has announced a new fast-track visa to attract elite scientists to live and work in the UK, in light of the nation leaving the European Union later this year. “I want the UK to continue to be a global science superpower, and when we leave the EU we will support science and research and ensure that, far from losing out, the scientific community has a huge opportunity to develop and export our innovation around the world,” Johnson said in a statement. [The Scientist] Editorial
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EVENTSNEW Annual World Congress on Insulin Resistance, Diabetes, and Cardiovascular Disease Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Researcher – Single Cell Biology and/or Vascular Biology (Heidelberg University) NEW Faculty Positions – Basic and Translational Cardiovascular Sciences (New York University) Scientific Communications Coordinator (STEMCELL Technologies Inc.) Postdoctoral Fellow – Cardiovascular Physiology (University of California, San Diego) Postdoctoral Fellowship – Cancer Therapeutics & Angiogenesis (Boston Children’s Hospital) Group Leader – Vascular Biology (Ludwig-Maximilians-University) Postdoctoral Position – Vascular Research (University of Illinois-Chicago) Faculty Positions – Cardiovascular Biomedical Research (Virginia Tech) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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