Endothelial Cell News Volume 4.40 | Dec 2 2019

TOP STORY

Missing Self Triggers NK Cell-Mediated Chronic Vascular Rejection of Solid Organ Transplants

Human in vitro models and transplantation of β2-microglobulin-deficient hearts into wild-type mice demonstrated that the inability of graft endothelial cells to provide HLA I-mediated inhibitory signals to recipient circulating NK cells triggered their activation, which in turn promoted endothelial damage. [Nat Commun] Full Article

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cAMP/EPAC Signaling Enables ETV2 to Induce Endothelial Cells with High Angiogenesis Potential

The ETV2-induced endothelial cells obtained via cAMP signaling activation showed superior angiogenesis in vivo as well as in vitro. [Mol Ther] Abstract | Graphical Abstract

Endothelial EphB4 Maintains Vascular Integrity and Transport Function in Adult Heart

The authors showed that inducible and endothelial cell-specific inactivation of Ephb4 in adult mice was compatible with survival, but led to rupturing of cardiac capillaries, cardiomyocyte hypertrophy, and pathological cardiac remodeling. [eLIFE] Full Article

Melatonin Inhibits Inflammasome-Associated Activation of Endothelium and Macrophages Attenuating Pulmonary Arterial Hypertension

Melatonin attenuated inflammasome-associated vascular disorders by directly improving endothelial leakage and decreasing the formation of inflammasome multiprotein complexes in macrophages. [Cardiovasc Res] Abstract

Coxsackievirus and Adenovirus Receptor Mediates the Responses of Endothelial Cells to Fluid Shear Stress

Investigators demonstrated the expression, regulatory mechanism, and role of coxsackievirus and adenovirus receptor in vascular endothelial cells under fluid shear stress conditions. [Exp Mol Med] Full Article

Up-Regulation of HDACs, a Harbinger of Uraemic Endothelial Dysfunction, Is Prevented by Defibrotide

The authors evaluated changes induced by chronic kidney disease on endothelial cell proteome and explored the effect of defibrotide and the mechanisms involved. [J Cell Mol Med] Full Article

Altered Processing Enhances the Efficacy of Small-Diameter Silk Fibroin Vascular Grafts

Scientists compared two electrospun silk grafts with different manufacturing processes, using either water or hexafluoroisopropanol as solvent. [Sci Rep] Full Article

VEGF/Flk1 Mechanism Is Involved in Roxarsone Promotion of Rat Endothelial Cell Growth and B16F10 Xenograft Tumor Angiogenesis

Researchers explored the mechanism of VEGF and its receptor in roxarsone promotion of rat vascular endothelial cells and B16F10 mouse xenografts. [Sci Rep] Full Article

Long Noncoding RNA XIST Participates Hypoxia-Induced Angiogenesis in Human Brain Microvascular Endothelial Cells through Regulating miR-485/SOX7 Axis

Investigators characterized the upregulation of X-inactive specific transcript silencing (XIST) in human brain microvascular endothelial cells under hypoxia condition. XIST impaired hypoxia-induced cell proliferation, migration and tube formation. [Microcirculation] Abstract

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The Role of Endothelial Cells and TNF-Receptor Superfamily Members in Lymphoid Organogenesis and Function During Health and Inflammation

Scientists discuss recent insights into endothelial cell (EC)-specific TNFRSF member signaling and highlight its importance in different EC subsets in lymph node organogenesis and function during health, and in lymphocyte activation and tertiary lymphoid structure formation during inflammation. [Front Immunol] Full Article

Visit our reviews page to see a complete list of reviews in the endothelial cell research field.

Chi-Med’s Elunate^® (Fruquintinib Capsules) Included in the National Reimbursement Drug List in China

Hutchison China MediTech Limited (Chi-Med) announced that Elunate^®, its national class 1 targeted anticancer drug for the treatment of patients with advanced colorectal cancer, has been included in the updated National Reimbursement Drug List released by China’s National Healthcare Security Administration. [Hutchison China MediTech Limited] Press Release

Cynata Files Application to Commence Phase II Clinical Trial in Critical Limb Ischaemia

Cynata Therapeutics Limited announced that it has filed a Clinical Trial Authorisation application with the UK Medicines and Healthcare products Regulatory Agency for the proposed Phase II clinical trial of Cynata’s Cymerus^® mesenchymal stem cell product CYP-002 in patients with critical limb ischaemia. [Cynata Therapeutics Limited (GlobeNewswire, Inc.)] Press Release

Elsevier Progresses in Open-Access Deal Making

The scholarly publisher has announced several new licensing agreements in both Europe and the US, but some major academic groups are still without contracts and access to journals. [The Scientist] Editorial

Stark Party Differences in ‘Brexit Election’ Could Shape Future of UK Science

When representatives of each party took to a stage last week at the Royal Society in London, they all promised increased funding and easier immigration for scientists. But Brexit loomed over the discussion, says Sarah Main, director of the Campaign for Science and Engineering, an advocacy group in London. [ScienceInsider] Editorial

NEW The Neurovascular Interface
September 14-16, 2020
Heidelberg, Germany

Visit our events page to see a complete list of events in the community.

NEW PhD Student – Metabolism and Vascular Function (Helmholtz Zentrum München)

NEW PhD Student – Molecular Obesity Research (Helmholtz Zentrum München)

NEW Research Specialist – Cell Biology (Howard Hughes Medical Institute)

Assistant or Associate Professor – Cardiovascular or Renal Physiology and Pharmacology (University of Southern Denmark)

Postdoctoral Researcher – Vascular Biology (University Medical Center Hamburg-Eppendorf)

Research Fellow – Vascular Stem Cell Biology (Queen’s University Belfast)

Faculty Positions – Tissue Regeneration Engineering (Dankook University)

Postdoctoral Fellow – 3D In Vitro Vascular Models (European Molecular Biology Laboratory)

Postdoctoral Fellow – Endothelial Cell Ion Channels (The University of Tennessee Health Science Center)

Postdoctoral Fellow – Endothelial Dysfunction and Malaria (Seattle Children’s Research Institute)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

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