Endothelial Cell News Volume 4.42 | Dec 16 2019

TOP STORY

Sphingosine-1-Phosphate Receptor 1 Activity Promotes Tumor Growth by Amplifying VEGF-VEGFR2 Angiogenic Signaling

Investigators showed that cancer cells induced sphingosine-1-phosphate receptor 1 (S1PR1) activity in endothelial cells (ECs), and thereby, conditional deletion of S1PR1 in ECs impaired tumor vascularization and growth. [Cell Rep] Full Article

(Ranked by impact factor of the journal)

Shear Stress Regulation of Endothelial Glycocalyx Structure Is Determined by Glucobiosynthesis

Both in vitro as well as in in vivo, hyaluronan expression on the endothelial surface was increased on laminar shear and reduced when exposed to oscillatory flow, which was regulated by Krüppel-like factor 2. [Arterioscler Thromb Vasc Biol] Abstract

Long Non-Coding RNA PAXIP1-AS1 Facilitates Cell Invasion and Angiogenesis of Glioma by Recruiting Transcription Factor ETS1 to Upregulate KIF14 Expression

Overexpression of long non-coding RNA PAX-interacting protein 1- antisense RNA1/ETS proto-oncogene 1 (PAXIP1-AS1) enhanced migration, invasion, and angiogenesis of HUVECs in glioma by recruiting the transcription factor ETS1 to upregulate the expression of kinesin family member 14 (KIF14), which was further confirmed by accelerated tumor growth in nude mice. [J Exp Clin Cancer Res] Full Article

Endothelial Progenitor Cells Inhibit Jaw Osteonecrosis in a Rat Model: A Major Adverse Effect of Bisphosphonate Therapy

Local injection of early and late endothelial progenitor cells healed 13 of 14 medication-related osteonecrosis of the jaw lesions compared with 2/7 lesions in the mesenchymal stem cells, and 2/6, in culture-medium group. [Sci Rep] Full Article

Fuzhenghuayu Decoction Ameliorates Hepatic Fibrosis by Attenuating Experimental Sinusoidal Capillarization and Liver Angiogenesis

Scientists investigated the effects of Fuzhenghuayu on sinusoidal capillarization and angiogenesis with mice challenged for carbon tetrachloride and dimethylnitrosamine, in vitro human hepatic sinusoidal endothelial cells and HUVEC 3D fibrin gel model. [Sci Rep] Full Article

P53 Regulates the Redox Status of Lung Endothelial Cells

The authors employed human and bovine lung endothelial cells, to investigate whether P53 expression levels affect the redox status of pulmonary cells. [Inflammation] Abstract

Polycaprolactone/Gelatin Degradable Vascular Grafts Simulating Endothelium Functions Modified by Nitric Oxide Generation

Scientists showed that modified polycaprolactone/gelatin grafts had strong catalytic nitric oxide generation capacity and facilitated the enhanced attachment of endothelial cells, compared with control scaffold groups. [Regen Med] Abstract | Graphical Abstract

Endothelial IL-8 Induced by Porcine Circovirus Type 2 Affects Dendritic Cell Maturation and Antigen-Presenting Function

Porcine circovirus type 2-induced endothelial IL-8 reduced the adhesion and migration ability of monocyte-derived dendridic cells (MoDCs), resulting in a decreased maturation rate of MoDCs, and further inhibited antigen presentation by dendritic cells. [Virol J] Full Article

A Novel Antitumor Strategy through Simultaneously Inhibiting Angiogenesis and Complement by Targeting VEGFA/PIGF and C3b/C4b

In vitro, angiogenesis effects induced by VEGF and hemolysis induced by complement were inhibited by VEGFR-Fc fusion protein (VID) and CR1-Fc fusion protein (CID), respectively. VID and CID confered a synergetic therapeutic effect in a colitis-associated colorectal cancer model and orthotopic 4T1 breast cancer model. [Mol Ther Oncolytics] Abstract

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Stem Cell-Derived Kidney Organoids: Engineering the Vasculature

Scientists review the main protocols for the generation of kidney organoids from human-induced pluripotent stem cells, discussing their advantages and limitations. In particular, they focus on the vascularization of the kidney organoids, which appears to be one of the critical factors to achieve maturation and functionality of the organoids. [Cell Mol Life Sci] Full Article

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CHMP Issues Positive Opinion to Expand CYRAMZA^® (Ramucirumab) Label to Include Results from RELAY Study in Patients with Metastatic EGFR-Mutated Non-Small Cell Lung Cancer

Eli Lilly and Company announced that the European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) issued a positive opinion recommending a new indication and associated label update for CYRAMZA^®, an antiangiogenic therapy. [Eli Lilly and Company] Press Release

Novartis Receives Positive CHMP Opinion for Beovu^® (Brolucizumab) for the Treatment of Wet AMD

Novartis announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency has adopted a positive opinion for Beovu^®, also known as RTH258, an investigational product for the treatment of wet age-related macular degeneration (AMD). [Novartis] Press Release

BioAxone BioSciences Expands Patent for Treatment of Cerebral Cavernous Malformations and Cerebral Aneurysms with Rho Kinase Inhibitors

BioAxone BioSciences, Inc. announced that it has received a Notice of Allowance from the United States Patent and Trademark Office. The notice refers to a critical patent application covering the oral drug candidate in development, BA-1049. [BioAxone BioSciences, Inc.] Press Release

UK Election Dashes Scientists’ Hopes of Staying in the EU

The United Kingdom is now firmly on the path towards leaving the European Union, after the Conservative party won a majority of 79 seats in yesterday’s general election – a result that has major implications for science. [Nature News] Editorial

United States Drops Charges against Two More Scientists after Iran Prisoner Swap

US authorities have dropped charges against two researchers accused of attempting to export chemicals to Iran in violation of trade sanctions. The decision follows a prisoner swap in which the United States freed a third researcher who was charged alongside them – and imprisoned. [Nature News] Editorial

NEW Lorne Cancer Conference
February 13-15, 2020
Lorne, Victoria, Australia

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Research Associate – Vascular Biology (University of Illinois)

Postdoctoral Researcher – Developmental Genetics and Cell Biology of the Vasculature (Peter MacCallum Cancer Centre)

PhD Student – Metabolism and Vascular Function (Helmholtz Zentrum München)

PhD Student – Molecular Obesity Research (Helmholtz Zentrum München)

Research Specialist – Cell Biology (Howard Hughes Medical Institute)

Assistant or Associate Professor – Cardiovascular or Renal Physiology and Pharmacology (University of Southern Denmark)

Postdoctoral Researcher – Vascular Biology (University Medical Center Hamburg-Eppendorf)

Faculty Positions – Tissue Regeneration Engineering (Dankook University)

Postdoctoral Fellow – 3D In Vitro Vascular Models (European Molecular Biology Laboratory)

Postdoctoral Fellow – Endothelial Cell Ion Channels (The University of Tennessee Health Science Center)

Postdoctoral Fellow – Endothelial Dysfunction and Malaria (Seattle Children’s Research Institute)

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