 | | Vol. 4.30 – 15 June, 2020 |
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| Inhibitors of oxidative phosphorylation and the ATP/ADP translocase suppressed FA uptake, pointing principally to ATP production. Decreasing total cellular ATP by blocking glycolysis did not decrease uptake, indicating that specifically mitochondrial ATP was required.
[Cell Metabolism] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors showed that neural-specific depletion of three members of the non-specific lethal chromatin complex—Mof, Kansl2 or Kansl3—unexpectedly led to severe vascular defects and brain hemorrhaging.
[Nature Cell Biology] |
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| Investigators showed that the somatic PIK3CAH1047R mutation, resulting in constitutive activation of the p110α PI3K, underlaid both macrocystic and microcystic lymphatic malformations (LMs) in human. Using a mouse model of PIK3CAH1047R-driven LMs, they demonstrated that both types of malformations arose due to lymphatic endothelial cell-autonomous defects, with the developmental timing of p110α activation determining the LM subtype.
[Nature Communications] |
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| Mechanistically, Angpt2 activated integrin α5β1 signaling in the endothelium and triggered fatty acid transport via CD36 and FATP3 into subcutaneous adipose tissue. Genetic or pharmacological inhibition of the endothelial integrin α5β1 recapitulated adipocyte-specific Angpt2 knockout phenotypes.
[Nature Communications] |
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| Mechanistically, RNA sequencing revealed that resolvin D1 induced a transcriptional program in macrophages characteristic of a pro-revascularization phenotype. Vascularization of ischemic skeletal muscle, as well as cutaneous wounds, was impaired in mice with myeloid-specific deficiency of Alx/Fpr2, and this was associated with altered expression of pro-revascularization genes in skeletal muscle and macrophages isolated from skeletal muscle.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers explored how pro-lymphangiogenic signaling affects the allergic response to house dust mite. In the acute inflammatory phase, the lungs of mice treated with blocking antibodies against VEGFR-3 displayed less inflammation overall, with dramatically reduced innate and T-cell numbers and reduced inflammatory chemokine levels.
[Mucosal Immunology] |
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| Investigators reported a new and unexpected function of Snail in endothelium generation by breast cancer cells. They showed that high Snail-expressing breast cancer cells isolated from patients showed more endothelium generated from these cells.
[Cell Death & Disease] |
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| The increased resistance observed for the non-endothelial cell types was accompanied by an increased rate of cellular attachment, even though spontaneous migration was comparable to the control, i.e., to the standard cultivation surface. As demonstrated on fibroblasts, the resistance to trypsin was similar in serum-supplemented and serum-free media.
[Scientific Reports] |
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| Researchers used electrophysiological studies in brain slices and structural analysis of post-mortem tissues obtained from animals exposed to endothelium-derived amyloids. The amyloids were administered via three different routes, by intracerebroventricular, intratracheal, and intraperitoneal injections.
[Scientific Reports] |
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| Scientists observed considerable downregulation of miR-503-5p expression in colon cancer cells and tissues and significant correlation with the TNM stage, differentiation grade and lymph node metastasis of colon cancer. Overexpression of miR-503-5p promoted the apoptosis and G1 arrest of colon cancer cells, and inhibited migration, proliferation, invasion and colony formation.
[Gene Therapy] |
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| Investigators demonstrated that TSGA10 over-expression significantly decreased HUVEC tubulogenesis and interconnected capillary network formation. HUVECs over-expressing TSGA10 exhibited a significant decrease in migration and proliferation rates.
[Genes] |
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| Conditioned medium (CM) from Radial Glia (RG) control cultures increased ZO-1 protein levels and organization on endothelial bEnd.3 cells membranes, which was impaired by CM from infected RG, accompanied by decreased trans-endothelial electrical resistance.
[Microvascular Research] |
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| The authors summarize nanotechnology-based strategies that have been explored in the broad area of angiogenesis. Lipid-based, carbon-based and polymeric nanoparticles, and a wide range of inorganic and metallic nanoparticles are covered in detail.
[Chemical Society Reviews] |
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| China’s plan to introduce a new security law in Hong Kong has prompted mixed reactions from scientists there. Some fear that such a law could lead to government interference in research, restrict participation in international collaborations and increase self-censorship, whereas others are confident that research will be unaffected.
[Nature News] |
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| Dr. Paul Cook, chief of the Division of Infectious Diseases at East Carolina Univesity’s Brody School of Medicine, began enrolling patients June 1 in a clinical trial investigating a new treatment aimed at preventing and shortening the duration of Acute Respiratory Distress Syndrome (ARDS). ARDS is a characteristic of COVID-19 that occurs when fluid builds up in the lungs and prevents oxygen from entering the bloodstream.
[East Carolina University] |
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| 2020-06-14 – 2020-06-15
Berlin, Germany |
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| | University of California, San Diego – San Diego, California, United States |
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| | UC Davis – Sacramento, California, United States |
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| | University College Dublin – Dublin, Ireland |
| | University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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| | The Chinese University of Hong Kong – Hong King, China |
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| | Aarhus University – Aarhus C, Denmark |
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| | University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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| | Universität Leipzig – Leipzig, Germany |
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| | KU Leuven and Sun Yat-Sen University – Various |
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| | Beam Therapeutics – Cambridge, Massachusetts, United States |
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