Endothelial Cell News Volume 5.23 | Jun 29 2020

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    2020-29-06 | ENDO 5.23


    Endothelial Cell News by STEMCELL Technologies
    Vol. 5.23 – 29 June, 2020
    TOP STORY

    Generation of Model Tissues with Dendritic Vascular Networks via Sacrificial Laser-Sintered Carbohydrate Templates

    Investigators showed that cell-laden hydrogels could be patterned with algorithmically generated dendritic vessel networks and other complex hierarchical networks by using sacrificial templates made from laser-sintered carbohydrate powders.
    [Nature Biomedical Engineering]

    Abstract
    View-On-Demand Webinar: Therapeutic Application of Endothelial Colony-Forming Cells. Watch Now.
    PUBLICATIONSRanked by the impact factor of the journal

    An Autophagic Deficit in the Uterine Vessel Microenvironment Provokes Hyperpermeability through Deregulated VEGFA, NOS1, and CTNNB1

    Deletion of Atg7 was confirmed by functional deficit of autophagy in uterine stromal, myometrial, and vascular smooth muscle cells, but not in endothelial cells.
    [Autophagy]

    Abstract

    Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis

    Scientists showed that tumor vascular function as well as pericyte coverage was significantly impaired in mice with conditional knockout of platelet-derived growth factor (PDGFB) in platelets.
    [Cancer Research]

    Abstract

    A Versatile Microfluidic Device for Multiple Ex Vivo/In Vitro Tissue Assays Unrestrained from Tissue Topography

    Using irregular tissues such as an aorta, scientists conducted multiple in vitro and ex vivo assays on tissue sections, including short-term culturing, a drug toxicity assay, a fluorescence immunohistochemistry staining assay, and an immune cell assay, in which they observed the interaction of neutrophils with lipopolysaccharide-stimulated endothelium.
    [Microsystems & Nanoengineering]

    Full Article

    Hyaloid Vasculature and mmp2 Activity Play a Role during Optic Fissure Fusion in Zebrafish

    Pharmacological inhibition of VEGF signaling phenocopied the pax2a−/− vasculature, F-actin and basement membrane degradation phenotypes.
    [Scientific Reports]

    Full Article

    Decreased miR-200b-3p in Cancer Cells Leads to Angiogenesis in HCC by Enhancing Endothelial ERG Expression

    Researchers investigated whether hepatocyte-derived miR-200b-3p governed angiogenesis in hepatocellular carcinoma (HCC) by targeting endothelial erythroblast transformation-specific-related gene (ERG).
    [Scientific Reports]

    Full Article

    Vascular Permeability Disruption Explored in the Proteomes of Mouse Lungs and Human Microvascular Cells following Acute Bromine Exposure

    Investigators surveyed the lung proteomes of C57BL/6 male mice and human lung derived microvascular endothelial cells at 24 hours following exposure to bromine in concentrations likely to be encountered in the vicinity of industrial accidents.
    [American Journal of Physiology-Lung Cellular and Molecular Physiology]

    Abstract

    Exoenzyme Y Induces Extracellular Active Caspase-7 Accumulation Independent from Apoptosis: Modulation of Transmissible Cytotoxicity

    To study the function of extracellular caspase-7, caspase-7- and caspase-3-deficient pulmonary microvascular endothelial cells were generated using CRISPR/Cas9 technology.
    [American Journal of Physiology-Lung Cellular and Molecular Physiology]

    Abstract

    A Somatic Activating KRAS Variant Identified in an Affected Lesion of a Patient with Gorham–Stout Disease

    To explore the pathogenesis of Gorham–Stout disease (GSD), scientists performed the amplicon-based deep sequencing on 50 cancer-related genes to assay affected tissues from the six patients with GSD.
    [Journal of Human Genetics]

    Abstract


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    REVIEWS

    New Tools to Prevent Cancer Growth and Spread: A ‘Clever’ Approach

    Clever-1 (also known as Stabilin-1 and FEEL-1) is a scavenger receptor expressed on lymphatic endothelial cells, sinusoidal endothelial cells and immunosuppressive monocytes and macrophages.
    [British Journal of Cancer]

    Full Article

    LIPG: An Inflammation and Cancer Modulator

    Since endothelial lipase predominantly functions as a phospholipase as well as presents low levels of triglyceride lipase activity, it plays an essential role in lipoprotein metabolism, and involves metabolic syndromes such as inflammatory response and atherosclerosis.
    [Cancer Gene Therapy]

    Abstract

    INDUSTRY AND POLICY NEWS

    NIH’s New Sexual-Harassment Rules Are Still Too Weak, Say Critics

    On 24 June, the US National Institutes of Health (NIH) described the actions it will take when alerted to reports of unsafe behavior, including restricting scientists from peer-review panels, holding back pending grants and refusing university requests to transfer funding to other institutions in cases where a harasser changes jobs.
    [Nature News]

    Press Release

    Graduate Programs Drop GRE after Online Version Raises Concerns about Fairness

    Scores of academics have raised concerns about the equity of the online version of the test, arguing it disadvantages prospective students from rural and low-income backgrounds. “If I were … a student trying to take this exam, satisfying criteria would be extremely difficult for me,” says Emily Levesque, an assistant professor of astronomy at the University of Washington, Seattle.
    [ScienceInsider]

    Press Release

    FEATURED EVENT

    The Neurovascular Interface

    September 14 – September 16
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    JOB OPPORTUNITIES

    Postdoctoral Fellow – Endothelial Cells in the Blood-Brain Barrier

    The University of Texas Health Science Center at Houston – Houston, Texas, United States

    Research Fellow – Endothelial and Cardiomyocyte Remodeling in Insulin Resistance

    Queen’s University Belfast – Belfast, United Kingdom

    Postdoctoral Fellow – Non-Coding RNAs in Vascular Disease

    The Brigham and Women’s Hospital – Boston, Massachusetts, United States

    Postdoctoral Researcher – Single Cell Analysis of Blood Vessels

    University of California, San Diego – San Diego, California, United States

    Specialist Researcher – Cardiovascular Medicine

    UC Davis – Sacramento, California, United States

    > See All Jobs

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