Endothelial Cell News Volume 5.26 | July 20 2020

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    ENDOCN 5.26 | July 20 2020


    Endothelial Cell News by STEMCELL Technologies
    Vol. 5.26 – 20 July, 2020
    TOP STORY

    Vascular Contributions to 16p11.2 Deletion Autism Syndrome Modeled in Mice

    Researchers showed that there was defective angiogenesis in primary 16p11.2df/+ mouse brain endothelial cells and in induced-pluripotent-stem-cell-derived endothelial cells from human carriers of the 16p11.2 deletion.
    [Nature Neuroscience]

    Abstract
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    Lactate Released by Inflammatory Bone Marrow Neutrophils Induces Their Mobilization via Endothelial GPR81 Signaling

    Investigators report that bacterial lipopolysaccharides or Salmonella typhimurium triggered lactate release by increasing glycolysis, NADPH-oxidase-mediated reactive oxygen species and HIF-1α levels in bone marrow neutrophils.
    [Nature Communications]

    Full Article

    The Bartonella Autotransporter BafA Activates the Host VEGF Pathway to Drive Angiogenesis

    BafA interacts with vascular endothelial growth factor (VEGF) receptor-2 and activated the downstream signaling pathway, suggesting that BafA functioned as a VEGF analog.
    [Nature Communications]

    Full ArticlePress Release

    A Collagen Vα1-Derived Fragment Inhibits FGF-2 Induced-Angiogenesis by Modulating Endothelial Cells Plasticity through Its Heparin-Binding Site

    Researchers showed that HEPV bound to FGF2 through its heparin-binding site. Using in vitro and in vivo angiogenesis assays, they showed that HEPV but not the HEPV mutant at the heparin-binding site, inhibited FGF2-dependent angiogenesis.
    [Matrix Biology]

    Abstract

    Circ-ADAM9 Targeting PTEN and ATG7 Promotes Autophagy and Apoptosis of Diabetic Endothelial Progenitor Cells by Sponging mir-20a-5p

    Scientists investigated the roles of mir-20a-5p and its predicted target circ-ADAM9 in endothelial progenitor cells treated with high glucose and in a diabetic mouse hind limb ischemia model.
    [Cell Death & Disease]

    Full Article

    Dual Roles of Chromatin Remodeling Protein BRG1 in Angiotensin II-Induced Endothelial–Mesenchymal Transition

    BRG1 knockdown or inhibition attenuated angiotensin II-induced endothelial–mesenchymal transition, as evidenced by down-regulation of CDH5, an endothelial marker, and up-regulation of COL1A2, a mesenchymal marker, in cultured vascular endothelial cells.
    [Cell Death & Disease]

    Full Article

    Therapeutic Targeting of 15-PGDH in Murine Pulmonary Fibrosis

    Long-term pharmacologic 15-PGDH inhibition (PGDHi) was well-tolerated, reduced the severity of pulmonary fibrotic lesions and extracellular matrix remodeling, and improved pulmonary function in bleomycin-treated mice.
    [Scientific Reports]

    Full Article

    The Pharmaceutical Solvent N-Methyl-2-Pyrollidone (NMP) Attenuates Inflammation through Krüppel-Like Factor 2 Activation to Reduce Atherogenesis

    The authors found that N-methyl-2-pyrrolidone attenuated monocyte adhesion to endothelial cells inflamed with tumor necrosis factor alpha by reducing expression of adhesion molecules.
    [Scientific Reports]

    Full Article

    Tritiated Water Induces Toxicity in Human Umbilical Vein Vascular Endothelial Cells via IL8

    Investigators evaluated cellular senescence, interleukin 8 concentrations, and angiogenesis using β-galactosidase staining, enzyme-linked immunosorbent assay, and in vitro assays, respectively.
    [Dose-Response]

    Full Article


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    REVIEWS

    Biological Functions of Lymphatic Vessels

    The authors discuss recent advances to understand previously unidentified functions of adult mammalian lymphatic vessels, including immunosurveillance.
    [Science]

    Abstract
    INDUSTRY AND POLICY NEWS

    Feinstein Institutes Receives $15 Million NIH Grant to Study Brain Dysfunction in Lupus

    The Feinstein Institutes for Medical Research has been awarded a $15 million grant to study brain dysfunction tied to lupus by the National Institutes of Health. Betty Diamond, MD, director of the Feinstein’s Institute of Molecular Medicine, will use the five-year grant to investigate the role of anti-N-methyl D-aspartate receptor.
    [The Feinstein Institutes for Medical Research (Business Wire, Inc.)]

    Press Release

    Open-Access Plan S to Allow Publishing in Any Journal

    Funding agencies behind the radical open-access initiative Plan S have announced a policy that could make it possible for researchers to bypass journals’ restrictions on open publishing.
    [Nature News]

    Editorial

    During the Pandemic, Students Do Field and Lab Work without Leaving Home

    Some researchers worry students will miss out on certain practical and problem-solving skills and won’t be able to judge whether the hands-on work of a scientist is a good fit for them. But instructors are developing high-tech ways to simulate the field and lab experiences.
    [ScienceInsider]

    Editorial

    FEATURED EVENT

    Myeloma and Plasma Cell Dyscrasias

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    JOB OPPORTUNITIES

    Postdoctoral Position – Cardiovascular and Cardiomyopathy Research

    Albert Einstein College of Medicine – New York, New York, United States

    Senior Postdoctoral Research Fellow – Molecular Mechanisms of Viral Pathogenesis

    Beth Israel Deaconess Medical Center – Boston, Massachusetts, United States

    Professor – Endothelial Cell Biology

    Universitätsklinikum Bonn – Bonn, Germany

    Postdoctoral Fellow – Endothelial Cells in the Blood-Brain Barrier

    The University of Texas Health Science Center at Houston – Houston, Texas, United States

    Research Fellow – Endothelial and Cardiomyocyte Remodeling in Insulin Resistance

    Queen’s University Belfast – Belfast, United Kingdom

    > See All Jobs

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