 | | Vol. 5.33 – 21 September, 2020 |
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| To investigate the transcriptomic basis of endothelial cell (EC) specificity, researchers analyzed single-cell RNA-sequencing data from tissue-specific mouse ECs generated by the Tabula Muris consortium.
[Circulation] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed proof-of-principle modeling of tumor progression and engineered cardiac tissue vascularization. They demonstrated that 3D curvature induced rotation and mixing under laminar flow, leading to unique phenotypic and transcriptional changes in endothelial cells.
[Science Advances] |
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| Previous studies have demonstrated that the expression of several lysine-specific demethylases is induced by hypoxia. The authors investigated the exact mechanisms underlying this regulation and its functional implications for endothelial cell function, such as angiogenesis.
[Arteriosclerosis Thrombosis and Vascular Biology] |
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| Researchers describe the design and synthesis of a panel of fluorinated L-fucose analogs bearing fluorine atoms at the C2 and/or C6 positions of L-fucose as metabolic fucosylation inhibitors. Preliminary study of their effects on cell proliferation revealed that the 6,6-difluoro-L-fucose and 6,6,6-trifluoro-L-fucose showed significant inhibitory activity against proliferation of human colon cancer cells and human umbilical vein endothelial cells.
[ACS Chemical Biology] |
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| Investigators attempted to enlarge the application range of mesenchymal stem cells with Sr incorporation in an osteoporotic bone regeneration model to evaluate whether Sr could assist in regeneration outcomes.
[International Journal of Oral Science] |
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| The authors tested the hypothesis that acute exposure of venous endothelial cells to high shear stress is associated with inflammatory responses that are regulated by NF-κB both in vitro and ex vivo.
[Scientific Reports] |
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| Scientists aimed to clarify the direct effects of SAMe on fatty acid-induced steatosis and oxidative stress in hepatic and endothelial cells.
[Molecules] |
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| Researchers successfully identified isolated endothelial progenitor cells from the peripheral blood of patients with coronary slow flow.
[Bioscience Reports] |
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| The authors provide a comprehensive perspective on the pivotal role of NLR-family pyrin domain-containing protein 3 (NLRP3) inflammasome activation in aggravating oxidative stress and endothelial dysfunction and the possible underlying mechanisms.
[Cell Death & Disease] |
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| Aerpio Pharmaceuticals, Inc. announced that it has completed patient enrollment in its double-blind, placebo-controlled Phase II trial in patients with elevated intraocular pressure associated with open angle glaucoma or ocular hypertension.
[Aerpio Pharmaceuticals, Inc.] |
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| Roche have announced that the European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) has recommended the approval of Tecentriq® in combination with Avastin® for the treatment of adult patients with advanced or unresectable hepatocellular carcinoma who have not received prior systemic therapy.
[Roche] |
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| October 13 – October 14
Virtual |
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| | Purdue University – West Lafayette, Indiana, United States |
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| | Miller School of Medicine – Miami, Florida, United States |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | United Therapeutics – Silver Spring, Maryland, United States |
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| | University of California, Davis – Davis, California, United States |
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