Endothelial Cell News Volume 5.38 | Nov 2 2020

May 12, 2022

2020-11-02 | ENDOCN 5.38

Endothelial Cell News by STEMCELL Technologies

Vol.5.38 – 2 November, 2020

TOP STORY

ANGPTL2-Containing
Small Extracellular Vesicles from Vascular Endothelial Cells Accelerate Leukemia Progression

The authors used seven cell-type specific mouse Cre lines to conditionally knockout Vps33b in Cdh5⁺ or Tie2⁺ endothelial cells, Lepr⁺ bone marrow perivascular cells, Osx⁺ osteo-progenitor cells, Pf4⁺ megakaryocytes and Tcf21⁺ spleen stromal cells.
[Journal of Clinical Investigation]

Abstract Full Article
Graphical Abstract

CloneR for Enhancing the Cloning Efficiency and Single-Cell Survival of hPSCs

PUBLICATIONSRanked by the impact factor of the journal

Genetically Engineered Magnetic Nanocages for Cancer Magneto-Catalytic Theranostics

Scientists demonstrated that encapsulin-produced magnetic iron oxide nanocomposites had excellent magnetic saturation and remnant magnetization properties, featuring superior magnetic-to-thermal conversion efficiency with an ultrahigh specific absorption rate of 2390 W/g to overcome the critical issues of magnetic hyperthermia therapy.
[Nature Communications]

Full Article

Slug
Regulates the Dll4-Notch-VEGFR2 Axis to Control Endothelial Cell Activation and Angiogenesis

Both endothelial cell-specific Slug re-expression and reduced Notch signaling, either by γ-secretase inhibition or loss of Dll4, rescued retinal angiogenesis in SlugKO mice.
[Nature Communications]

Full Article

Leukemia-on-a-Chip:
Dissecting the Chemoresistance Mechanisms in B Cell Acute Lymphoblastic Leukemia Bone Marrow Niche

Investigators demonstrated an in vitro organotypic “leukemia-on-a-chip” model to emulate the in vivo B cell acute lymphoblastic leukemia (B-ALL) bone marrow (BN) pathology and comparatively studied the spatial and genetic heterogeneity of the BM niche in regulating B-ALL chemotherapy resistance.
[Science Advances]

Full Article

Improvement
of Islet Transplantation by the Fusion of Islet Cells with Functional Blood Vessels

Scientists introduce a novel strategy for the generation of prevascularized islet organoids by the fusion of pancreatic islet cells with functional native microvessels.
[EMBO Molecular Medicine]

Full Article

An
Allosteric Peptide Inhibitor of HIF-1α Regulates Hypoxia-Induced Retinal Neovascularization

Researchers showed that a peptide fragment of CITED2 was taken up by retinal cells and efficiently regulated pathological angiogenesis in murine models of ischemic retinopathy.
[Proceedings of the National Academy of Sciences of the United States of America]

Abstract

A
CRISPR-Cas9 Screen Identifies Mitochondrial Translation as an Essential Process in Latent KSHV Infection of Human Endothelial Cells

Using a pooled CRISPR-Cas9 lentivirus library, researchers identified host factors that were essential for the survival or proliferation of latently infected endothelial cells in culture, but not their uninfected counterparts.
[Proceedings of the National Academy of Sciences of the United States of America]

Abstract

Bone
Marrow Stromal Cells Stimulated by Strontium-Substituted Calcium Silicate Ceramics: Release of Exosomal miR-146a Regulates Osteogenesis and Angiogenesis

Researchers showed that bone marrow stem cell-derived exosomes after strontium-substituted calcium silicate stimulation could significantly promote in vitro angiogenesis of human umbilical vein endothelial cells, which might be attributed to elevated pro-angiogenic miR-146a cargos and inhibition of Smad4 and NF2 proteins.
[Acta Biomaterialia]

Abstract Graphical Abstract

Long
Non-Coding RNA MIAT Regulates Blood Tumor Barrier Permeability by Functioning as a Competing Endogenous RNA

The authors demonstrated that MIAT, ZAK, and phosphorylated NFκB-p65 were upregulated, while miR-140-3p was downregulated in glioma-exposed endothelial cells of blood-tumor barrier compared with those in endothelial cells co-cultured with astrocytes of blood–brain barrier.
[Cell Death & Disease]

Full Article

Pyruvate
Kinase M2 Mediates the Glycolysis in the Lymphatic Endothelial Cells and Its Potential Relation to the Progression of Lymphatic Malformations

The glycolysis index, including glucose uptake, ATP and lactate production stayed at a relatively high level in human dermal lymphatic endothelial cells (HDLECs) compared with HUVECS, while inhibition of PKM2 by shikinon or PKM2 knockdown could significantly suppress glycolysis, migration, tubular formation, and invasion of HDLECs.
[American Journal of Pathology]

Abstract

Derive and expand human endothelial cells with EC-Cult™-XF Culture Kit.

REVIEWS

The Endothelium: An Active Regulator of Lipid and Glucose Homeostasis

Researchers summarize recent progress in the understanding of regulated fatty acid, glucose, and insulin transport across the endothelium and discusses its pathophysiological implications.
[Trends in Cell Biology]

Abstract

Age-Related Cerebral Small Vessel Disease and Inflammaging

Investigators discuss recent findings in the pathophysiology of inflammaging and their effects on the development of age-related cerebral small vessel diseases (CSVD). They speculate the inflammaging as a potential target for future therapeutic interventions to delay or prevent the progression of the age-related CSVD.
[Cell Death & Disease]

Full Article

INDUSTRY AND POLICY NEWS

European
Commission Approves Roche’s Tecentriq in Combination with Avastin for the Treatment of People with the Most Common Form of Liver Cancer

Roche announced that the European Commission has approved Tecentriq^® in combination with Avastin^® for the treatment of adult patients with advanced or unresectable hepatocellular carcinoma who have not received prior systemic therapy.
[Roche]

Press Release

FEATURED EVENT

ANGPTL2-Containing
Small Extracellular Vesicles from Vascular Endothelial Cells Accelerate Leukemia Progression

Genetically Engineered Magnetic Nanocages for Cancer Magneto-Catalytic Theranostics

Slug
Regulates the Dll4-Notch-VEGFR2 Axis to Control Endothelial Cell Activation and Angiogenesis

Leukemia-on-a-Chip:
Dissecting the Chemoresistance Mechanisms in B Cell Acute Lymphoblastic Leukemia Bone Marrow Niche

Improvement
of Islet Transplantation by the Fusion of Islet Cells with Functional Blood Vessels

An
Allosteric Peptide Inhibitor of HIF-1α Regulates Hypoxia-Induced Retinal Neovascularization

A
CRISPR-Cas9 Screen Identifies Mitochondrial Translation as an Essential Process in Latent KSHV Infection of Human Endothelial Cells

Bone
Marrow Stromal Cells Stimulated by Strontium-Substituted Calcium Silicate Ceramics: Release of Exosomal miR-146a Regulates Osteogenesis and Angiogenesis

Long
Non-Coding RNA MIAT Regulates Blood Tumor Barrier Permeability by Functioning as a Competing Endogenous RNA

Pyruvate
Kinase M2 Mediates the Glycolysis in the Lymphatic Endothelial Cells and Its Potential Relation to the Progression of Lymphatic Malformations

The Endothelium: An Active Regulator of Lipid and Glucose Homeostasis

Age-Related Cerebral Small Vessel Disease and Inflammaging

European
Commission Approves Roche’s Tecentriq in Combination with Avastin for the Treatment of People with the Most Common Form of Liver Cancer

Keystone
Symposia: Tumor Metabolism and the Microenvironment

> See All Events

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Research Associate – Cerebrovascular Development and Disease

Postdoctoral Researcher – Endothelial Cell Metabolism in Illness

Postdoctoral
/ PhD Student – Placental Vascular Immune Response

Postdoctoral Fellowship – Clinical Research in Autonomic Dysfunctions

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