 | | Vol. 5.39 – 9 November, 2020 |
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| To access human endocardial cells, investigators generated a human PSC-derived endothelial population that displayed many characteristics of endocardium, including expression of the cohort of genes that identifies this lineage in vivo, the capacity to induce a trabecular fate in immature cardiomyocytes in vitro, and the ability to undergo EMT.
[Cell Stem Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| In vitro, epigenome‐editing of C‐C motif chemokine ligand 2 (CCL2) enhancer and promoter regions by CRISPR‐dCas9‐KRAB technology repressed TNFα‐induced CCL2 transcription via H3K9 tri‐methylation.
[Hepatology] |
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| Investigators report in-depth single-cell RNA sequencing, combined with spatial transcriptomics and immunohistochemistry, to comprehensively characterize subclasses of brain endothelial cells under both normal conditions and after deletion of Pdcd10 in a mouse model of cerebral cavernous malformation.
[eLife] |
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| Researchers showed that bone marrow stem cell-derived exosomes after strontium-substituted calcium silicate stimulation could significantly promote in vitro angiogenesis of human umbilical vein endothelial cells, which might be attributed to elevated pro-angiogenic miR-146a cargos and inhibition of Smad4 and NF2 proteins.
[Acta Biomaterialia] |
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| Human umbilical cord MSCs (hucMSCs) and HUVECs were isolated from human umbilical cords and characterized by a series of experiments. Lentivirus vector encoding miRNA-126-3p was transfected into hucMSCs and verified by PCR.
[Stem Cell Research & Therapy] |
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| Overexpression of ZNF354C in human endothelial cells results in a marked inhibition of endothelial sprouting. RNA-sequencing of human microvascular endothelial cells with and without overexpression of ZNF354C revealed that the protein is a potent transcriptional repressor.
[Scientific Reports] |
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| The CARD8 mRNA was knocked-down in HUVECs in vitro, followed by quantitative RT-PCR analysis and OLINK Proteomics. Endothelial and smooth muscle cells in arterial tissue expressed CARD8 and CARD8 correlated with vWF, CD163 and the expression of inflammatory genes, such as CXCL1, CXCL6 and PDGF-A in plaque.
[Scientific Reports] |
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| The glycolysis index, including glucose uptake, ATP and lactate production stayed at a relatively high level in human dermal lymphatic endothelial cells (HDLECs) compared with HUVECS, while inhibition of PKM2 by shikinon or PKM2 knockdown could significantly suppress glycolysis, migration, tubular formation, and invasion of HDLECs.
[American Journal of Pathology] |
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| While treatment with exosomes obtained from untreated breast cancer cells, tumor cell-derived exosomes (TDE), enhanced the expression of vVEGF-A in human umbilical vein endothelial cells, incubation with DHA or TDE led to the significant decrease of VEGF-A transcript level in these cells.
[Life Sciences] |
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| The authors illuminate the current status quo of carbon nanomaterials-vascular research and inspire further exciting progress via the insights they gained from the current outstanding examples.
[Journal of Controlled Release] |
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| Studies signal that damage to the endothelium- cells that cover blood vessels like wallpaper- could underpin the thrombosis and inflammation induced by coronavirus infection.
[The Scientist] |
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| INmune Bio, Inc. announced that the first patient has been dosed in its Phase IIclinical trial evaluating Quellor™ for the treatment of pulmonary complications from COVID-19. Quellor™ is a selective soluble Tumor Necrosis Factor inhibitor designed to potentially prevent the progression of immune mediated pulmonary complications resulting from SARS-CoV-2 viral infection.
[INmune Bio, Inc.] |
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| April 9 – April 14, 2021
Washington, DC, United States |
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| | Novo Nordisk A/S – Copenhagen, Denmark |
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| | Universität Leipzig – Leipzig, Germany |
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| | The University of Sheffield – Sheffield, England, United Kingdom |
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| | Technical University of Denmark – Lyngby, Denmark |
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| | Purdue University – West Lafayette, Indiana, United States |
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