 | | Vol. 6.04 – 1 February, 2021 |
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| Investigators report the identification of a set of NF-κB-bound elements and common chromatin landscapes underlying the acute inflammatory response across cell-types and mammalian species.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors explored the kinetics and individual cellular responses of endothelial cells after myocardial infarction by using single cell RNA sequencing.
[Nature Communications] |
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| Functional experiments were conducted to examine the platelet phagocytosis and cell aging using the overexpression or knockdown plasmids of SIRT1 and GIRDIN as well as Akt inhibitor and activator.
[Molecular Therapy-Nucleic Acids] |
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| A pharmacovigilance disproportionality analysis using the World Health Organisation’s global database was conducted. Scientists then investigated the effect of leflunomide on human pulmonary endothelial cells.
[Annals of the American Thoracic Society] |
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| Hyaluronan synthase 2 was strongly expressed in endothelial progenitor cells in the thickened intima. Moyamoya disease lesions showed minimal staining for chondroitin sulfate and hyaluronan in the endothelium, in contrast to control endothelium showing positive staining for both.
[Scientific Reports] |
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| The inducible inflammatory phenotypes of endothelial cell from heart, lung, kidney, and liver were characterized in vitro, focused on expression of adhesion molecules and chemokines, and recruitment of allogeneic peripheral blood mononuclear immune cells.
[Scientific Reports] |
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| A review of the bone marrow showed an increase in the number of megakaryocytes, vascular structures, as well as increased intensity of stain for VEGF, and CXC chemokine receptor 4 in rats with iron deficiency anemia compared to controls.
[Pediatric Research] |
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| A leaky vasculature resulted in higher docetaxel tumor levels compared to normal brain. Nevertheless, Abcb1 could reduce drug distribution and efficacy even in leaky models.
[Cell Reports Medicine] |
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| The authors analyze and organize the latest information about the available dental stem cells, the types of growth factors with pro-angiogenic effect and the possible therapeutic effect of enhanced angiogenesis in regenerative dentistry.
[International Journal of Molecular Sciences] |
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| EyePoint Pharmaceuticals, Inc. announced that the first patient has been dosed in the Phase I clinical trial of EYP-1901 as a potential twice-yearly sustained delivery anti-VEGF treatment targeting wet age-related macular degeneration.
[EyePoint Pharmaceuticals, Inc.] |
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| | F. Hoffmann-La Roche AG – Basel, Switzerland |
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| | University of Birmingham – Birmingham, England, United Kingdom |
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| | University of California San Francisco – San Francisco, California, United States |
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| | Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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| | University of Buffalo – Buffalo, New York, United States |
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