 | | Vol. 6.08 – 08 March, 2021 |
| |
|
|
| Primary human, rat and mouse liver sinusoidal endothelial cells were used. Histone deacetylase 6 was overexpressed specifically in liver endothelial cell via adeno-associated virus-mediated gene delivery to decrease Hsp90 acetylation in ethanol-fed mice.
[Journal of Hepatology] |
|  |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Researchers report that Myct1, a direct target of ETV2, was nearly exclusively expressed in endothelial cells. In preclinical mouse tumor models, Myct1 deficiency reduced angiogenesis, enhanced high endothelial venule formation, and promoted anti-tumor immunity, leading to restricted tumor progression.
[Science Translational Medicine] |
|
|
|
| The authors identified that bladder cancer (BCa) cell-secreted extracellular vesicles mediated the intercellular communication with human lymphatic endothelial cells through the transmission of a long noncoding RNA ELNAT1, and promoted lymphangiogenesis and lymph node metastasis in a SUMOylation-dependent manner in both cultured BCa cell lines and mouse models.
[Journal of Clinical Investigation] |
|
|
|
| Researchers studied the effects of the proinflammatory cytokine TNFα on transendothelial permeability and electrophysiology in ex vivo murine veins and arteries.
[Science Signaling] |
|
|
|
| Investigators uncovered a previously unknown expression and function of lymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE-1) in oral squamous cell carcinoma, whereby tumor cells could induce lymphatic mimicry formation and promote lymphatic metastasis.
[Oncogenesis] |
|
|
|
| Scientists compared reactive and macrometastatic axillary lymph node by combining whole section multiplex immunofluorescence with TMT-labelled LC-MS/MS of the circulating perfusate.
[npj Breast Cancer] |
|
|
|
| Researchers generated hypoxia-inducible factor 2α (HIF2A) gain-of-function induced pluripotent stem cells and differentiated them into endothelial cells and smooth muscle cells.
[iScience] |
|
|
|
| Investigators hypothesized that human intravital microscopy (HIVM) would be feasible in patients with peritoneal carcinomatosis (PC). During cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for PC, HIVM was performed in both tumor and non-tumor areas.
[Scientific Reports] |
|
|
|
| The authors found that the mutant induced changes in cell morphology and activated SGK1, a serine/threonine kinase known to regulate cell proliferation and apoptosis, via non-canonical activation.
[HGG Advances] |
|
|
|
|
| Scientists concentrate on research regarding the antiangiogenic effects of aspirin in cancer, and they discuss the molecular mechanisms of aspirin and its metabolites.
[European Journal of Pharmacology] |
|
|
|
|
| Clearside Biomedical, Inc. announced completion of dosing in the first cohort of OASIS, its ongoing Phase I/IIa clinical trial of CLS-AX in patients with neovascular age-related macular degeneration (wet AMD).
[Clearside Biomedical, Inc.] |
|
|
|
| Quantum Leap Healthcare Collaborative will not proceed with further testing of the Aerpio Pharmaceuticals drug, razuprotafib. Razuprotafib was chosen for testing in the I-SPY COVID Trial because it was hypothesized to stabilize and repair the blood vessels in the lung and improve gas exchange.
[Quantum Leap Healthcare] |
|
|
|
|
|
|
|
| | Imperial College London – London, England, United Kingdom |
|
|
|
| | Albert Einstein College of Medicine – Bronx, New York, United States |
|
|
|
| | Karolinska Institutet – Stockholm, Sweden |
|
|
|
| | CyberCoders – San Diego, California, United States |
|
|
|
| | Imperial College London – London, England, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
