 | | Vol. 6.13 – 19 April, 2021 |
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| Investigators report that patients with sporadic amyotrophic lateral sclerosis (ALS) present cell activity patterns consistent with two mouse models in which enrichments of vascular cell genes preceded microglial response.
[Nature Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists report that zinc oxide nanoparticles can induce ferroptosis of both HUVECs and EA.hy926 cells, as evidenced by the elevation of intracellular iron levels, lipid peroxidation and cell death in a dose- and time-dependent manner.
[Autophagy] |
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| Scientists discuss the role of ncRNAs in mediating angiogenesis in various types of gastrointestinal cancers and look forward to the introduction of mimetics and antagonists as possible therapeutic agents.
[Molecular Therapy-Oncolytics] |
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| Investigators created a high throughput screening and identified SB216763, an inhibitor of glycogen synthase kinase 3, as an inducer of osteoblastic-endothelial transition.
[JCI Insight] |
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| Researchers describe a crystal structure of the CD146/AA98 Fab complex at 2.8 Å resolution. Monomeric CD146 was stabilized by AA98 Fab binding to the junction region of CD146 domains 4 and 5.
[iScience] |
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| The authors report a protein–protein interaction inhibitor of SR protein kinases (SRPKs), docking blocker of SRPK1, that specifically blocked a conserved substrate docking groove unique to SRPKs.
[iScience] |
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| Investigators detected the expression of the tripartite motif-containing 27 (TRIM27) protein in glomerular endothelial cells in vivo and in vitro.
[Laboratory Investigation] |
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| The authors investigated the role of transient receptor potential vanilloid 4 in serotonin-induced plasma extravasation using pharmacological and genetic approaches.
[Laboratory Investigation] |
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| Human primary-cultured lymphatic endothelial cells were obtained both from lymphangioleiomyomatosis-affected lung tissues and normal lung tissues using fluorescence-activated cell sorting.
[Scientific Reports] |
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| Cultured HUVECs were cultured in bone marrow mesenchymal stem cell conditioned medium.
[Bioscience Reports] |
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| Since the switches among metabolic processes precede the functional changes and disease developments, some prophylactic and/or therapeutic strategies concerning the role of glycolysis in cardiovascular disease are discussed.
[Acta Pharmacologica Sinica] |
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| Scientists discuss the role of ncRNAs in mediating angiogenesis in various types of gastrointestinal cancers and look forward to the introduction of mimetics and antagonists as possible therapeutic agents.
[Molecular Therapy-Oncolytics] |
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| aTyr Pharma, Inc. and Lonza announced that the companies have entered into an agreement for the manufacture of ATYR2810, aTyr’s monoclonal antibody targeting Neuropilin-2 that was currently in preclinical development for cancer.
[aTyr Pharma, Inc. (BusinessWire, Inc.)] |
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| Prestige BioPharma and Pharmapark LLC announced that the two companies have entered into a binding agreement for the exclusive partnership and supply for the commercialization of Prestige BioPharma’s Bevacizumab biosimilar in the Russian Federation.
[Prestige BioPharma and Pharmapark LLC] |
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| January 12 – 14, 2022
Shanghai, China |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| | The University of Tennessee Health Science Center – Memphis, Tennessee, United States |
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| | Boston Children’s Hospital – Boston, Massachusetts, United States |
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| | Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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