 | | Vol. 6.14 – 26 April, 2021 |
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| Investigators used an unbiased RNA sequencing approach in complementary models of cystic fibrosis transmembrane conductance regulator (CFTR) silencing and blockade in human endothelial cells to characterise the changes upon CFTR impairment.
[European Respiratory Journal] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The fibrogenic phenotype in the kidneys of diabetic mice lacking endothelial glucocorticoid receptor was associated with aberrant cytokine and chemokine reprogramming, augmented Wnt signaling and suppression of fatty acid oxidation.
[Nature Communications] |
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| Researchers investigated whether the neuroimmune dysregulation vascular phenotype was intrinsically compromised in the most common genetic risk factor for schizophrenia, the 22q11.2 deletion syndrome.
[Brain] |
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| Scientists aimed to investigate the role of GAS5 in wound healing in diabetic foot ulcer as well as the underlying mechanism.
[Laboratory Investigation] |
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| The authors utilized a lineage tracing model of platelet-derived growth factor receptor alpha (PDGFRa) cells and examined cellular behavior during homeostasis and injury response.
[Scientific Reports] |
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| The expression of nuclear factor-erythroid 2-related factor 2 (Nrf2), heme oxygenase 1 (HO-1), and VEGF in BGC-823 cells under hypoxia was analyzed using immunocytochemistry, immunofluorescence, Western blotting, and quantitative PCR.
[Cancer Management and Research] |
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| To isolate adipose-derived human microvascular endothelial cells, scientists analyzed the supernatant discarded when adipose stem cells were isolated from the adipose-derived stromal vascular fraction.
[Tissue Engineering and Regenerative Medicine] |
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| Apatinib was used to treat hepatocellular carcinoma (HCC) cells transfected with or without VEGFR2 overexpression vectors. The proliferation of HCC cells was detected by MTT assay.
[Molecular Medicine Reports] |
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| Investigators describe the latest advances in the understanding of miRNAs and their corresponding targets that play a role in colorectal cancer angiogenesis and discuss possible miRNA-based therapeutic strategies.
[Cancer Cell International] |
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| The authors discuss the diagnosis and management of the most common intracranial and extracranial vascular malformations and tumors in the head and neck in children and adolescents.
[Pediatric Radiology] |
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| D&D Pharmatech, Inc. announced it has entered into a sponsored research agreement with Yale University relating to optimization of two novel approaches that allow immune system cells and drug molecules to bypass the blood-brain barrier for the treatment of brain cancer and other disorders.
[D&D Pharmatech, Inc. (Business Wire, Inc.))] |
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| Humacyte, Inc. announced that five-year data from a Phase II clinical trial of patients receiving the human acellular vessels (HAV) for arteriovenous access in hemodialysis suggest the long-term durability and functional hemodialysis access of the HAV.
[Humacyte, Inc. (GlobeNewswire, Inc.)] |
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| | LSU Health Science Center – Shreveport, Louisianam United States |
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| | Aarhus University – Copenhagen, Denmark |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| | The University of Tennessee Health Science Center – Memphis, Tennessee, United States |
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| | Boston Children’s Hospital – Boston, Massachusetts, United States |
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