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| Investigators showed that that intestinal lymphatic endothelial cells (LECs) have an increasing CD36 expression from lymphatic capillaries to collecting vessels, and that LEC CD36 regulated lymphatic integrity and optimized lipid transport.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers found that elevating cytoplasmic zinc using ionophores relaxed rat and human isolated blood vessels and caused hyperpolarization of smooth muscle membrane.
[Nature Communications] |
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| Scientists showed that elevated levels of Delta-like 1 (DLL1) in the breast and lung tumor microenvironment induced long-term tumor vascular normalization to alleviate tumor hypoxia and promoted the accumulation of interferon γ–expressing CD8+ T cells and the polarization of M1-like macrophages.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers showed the delivery of miR-21-5p from colorectal cancer (CRC) cells to endothelial cells via exosomes increased the amount of miR-21-5p in recipient cells, suggesting that exosomal miR-21-5p was involved in angiogenesis and vascular permeability in CRC.
[Cell Death & Disease] |
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| Investigators showed that the expression level of interleukin (IL)-37 variant was remarkably downregulated in HUVECs exposed to Kawasaki disease sera-treated THP1 cells.
[Cell Death & Disease] |
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| The endothelin-1 in the functional hydrogels significantly promoted the proliferation, migration and angiogenesis-related gene expression of HUVECs and fibroblasts.
[Journal of Materials Chemistry B] |
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| Researchers evaluated the commercially-available decellularized skin dermis ECM Alloderm for efficacy in providing structure to biological engineered blood vessels.
[Scientific Reports] |
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| Scientists evaluated the effect of high glucose concentration on senescence in human retinal endothelial cells and modulation of that effect by Sulodexide.
[Scientific Reports] |
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| Investigators showed that under time-averaged simulated microgravity, the thickness of the endothelial cell arrangement increased by up to 59.75%, indicating skin irritation due to vasodilation, and that the diameter of keratinocytes and fibroblast co-cultured spheroids decreased by 6.66%, representing skin thinning.
[npj Microgravity] |
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| Scientists evaluated the effect of the supernatant of placental explants from preeclamptic and normotensive pregnant women after tissue treatment with or without vitamin D on oxidative stress and nitric oxide bioavailability in HUVECs.
[Brazilian Journal of Medical and Biological Research] |
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| The clinical features of COVID-19, the central role of the endothelium in COVID-19 and in other pathologies, and the potential of specific therapies aimed at protecting the endothelium in COVID-19 patients are addressed.
[Cardiovascular Drugs and Therapy] |
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| Heartseed, Inc. and Novo Nordisk A/S announced that they have entered into a collaboration and licence agreement for the development, manufacturing and commercialization of Heartseed’s asset HS-001, an investigational cell therapy using purified cardiomyocytes derived from induced pluripotent stem cells, which is currently under development by Heartseed for the treatment of heart failure.
[Heartseed, Inc.] |
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| July 8 – 10, 2021
Boston, Massachusetts, United States |
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| | Pfizer, Inc. – Cambridge, Massachusetts, United States |
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| Gilead Sciences, Inc. – Foster City, California, United States |
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| Brigham and Women’s Hospital – Boston, Massachusetts, United States |
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| | University of Nebraska Medical Center – Omaha, Nebraska, United States |
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| | Stanford University – Stanford, California, United States |
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