Endothelial Cell News Volume 6.29 | Aug 23 2021

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    2021-08-23 | ENDOCN 6.29


    Endothelial Cell News by STEMCELL Technologies
    Vol. 6.29 – 23 August, 2021
    TOP STORY

    Apolipoprotein M and Sphingosine-1-Phosphate Receptor 1 Promote the Transendothelial Transport of High-Density Lipoprotein

    High-density lipoproteins were isolated from plasma of wild-type mice, Apom knockout mice, human apoM transgenic mice or humans and radioiodinated to trace its binding, association, and transport by bovine or human aortic endothelial cells.
    [Arteriosclerosis, Thrombosis, and Vascular Biology]

    Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Novel Paracrine Action of Endothelium Enhances Glucose Uptake in Muscle and Fat

    Despite endothelial cell insulin and insulin like growth factor-1 (IGF-1) resistance, mutant IGF-1R endothelial cell over-expressing mice had enhanced insulin and IGF-1 mediated systemic glucose disposal, lower fasting free fatty acids and triglycerides.
    [Circulation Research]

    Abstract

    FGF2-Primed 3D Spheroids Producing IL-8 Promote Therapeutic Angiogenesis in Murine Hindlimb Ischemia

    Scientists demonstrated that IL-8 was upregulated by the fibroblast growth factor 2 (FGF2)-mediated priming effect during FECS-Ad formation. Immobilized FGF2 substrate induced stronger IL-8 expression than soluble FGF2 ligands, presumably through the FGFR1/JNK/NF-κB signaling cascade.
    [npj Regenerative Medicine]

    Full Article

    Lysosome Purinergic Receptor P2X4 Regulates Neoangiogenesis Induced by Microvesicles from Sarcoma Patients

    Using a proteomic approach, investigators analyzed the protein content of plasma extracellular vesicles and identified critical activated pathways in human umbilical vein endothelial cells and human progenitor hematopoietic cells.
    [Cell Death & Disease]

    Full Article

    Knockdown of Salusin-β Improves Cardiovascular Function in Myocardial Infarction-Induced Chronic Heart Failure Rats

    The authors investigated the effects of silencing salusin-β on endothelial function, cardiac function, vascular and myocardial remodeling, and its underlying signaling pathways in chronic heart failure rats induced by coronary artery ligation.
    [Oxidative Medicine and Cellular Longevity]

    Full Article

    Cholenic Acid Derivative UniPR1331 Impairs Tumor Angiogenesis via Blockade of VEGF/VEGFR2 in Addition to Eph/Ephrin

    Investgiators employed an analysis pipeline consisting of molecular modeling and simulation, surface plasmon resonance spectrometry, biochemical assays, and endothelial cell models to demonstrate that UniPR1331 directly interacted with theVEGF receptor 2.
    [Cancer Gene Therapy]

    Abstract

    Investigating the Effects of Coenzyme Q10 on Human Corneal Endothelial Cells

    HCEC-12 cells were cultured in different concentrations of Coenzyme Q10 (CoQ10) and analyzed using live/dead staining assay to determine appropriate concentration for subsequent experiments.
    [American Journal of Ophthalmology]

    Full Article

    miR-181c-5p Mediates Apoptosis of Vascular Endothelial Cells Induced by Hyperoxemia via ceRNA Crosstalk

    The molecular mechanism by which hyperoxia injures pulmonary capillary endothelial cells has not been fully elucidated. Scientists systematically investigated these issues using next-generation sequencing and functional research techniques by focusing on non-coding RNAs.
    [Scientific Reports]

    Full Article

    Exosome-Derived SNHG16 Sponging miR-4500 Activates HUVEC Angiogenesis by Targeting GALNT1 via PI3K/Akt/mTOR Pathway in Hepatocellular Carcinoma

    The proliferative, migratory, and angiogenic abilities of HUVECs were enhanced after exposure to exosomes derived from hepatocellular carcionoma cells by transmitting small nucleolar RNA host gene 16 (SNHG16). SNHG16 was validated to promote the biological function of HUVECs directly.
    [Journal of Physiology and Biochemistry]

    Abstract

    Cells of the Human Respiratory Tract Support the Replication of Pathogenic Old World Orthohantavirus Puumala

    Researchers analyzed the permissiveness of primary endothelial cells of the human pulmonary microvasculature and of primary human epithelial cells derived from bronchi, bronchioles and alveoli for Old World orthohantavirus Puumala virus in vitro.
    [Virology Journal]

    Full Article
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    REVIEWS

    Drug Delivery Strategies in Maximizing Anti-Angiogenesis and Anti-Tumor Immunity

    The authors delve into the mechanisms behind anti-tumor immunity and seeks to identify the differential effect of dosing regimens, including daily low-dose and medium-dose intermittent chemotherapy, on both innate and adaptive immune populations involved in observed anti-tumor immune response.
    [Advanced Drug Delivery Reviews]

    AbstractGraphical Abstract

    Putting Function Back in Dysfunction: Endothelial Diseases and Current Therapies in Hematopoietic Stem Cell Transplantation and Cellular Therapies

    Scientists summarize the current knowledge about statins and other agents used as endothelial protectants. They propose further studies using statins for prophylaxis and prevention of end-organ damage related to extensive endothelial dysfunction in hematopoietic stem cell transplantation and chimeric antigen receptor-T cells.
    [Blood Reviews]

    Abstract
    INDUSTRY AND POLICY NEWS

    Ceapro, Inc. Enters into Research Collaboration with the Angiogenesis Foundation for Beta Glucan and Avenanthramides

    Ceapro, Inc. announced it has established a formal research collaboration with the Boston-based Angiogenesis Foundation, a prestigious independent scientific organization focused on driving innovations in health promotion, disease prevention, and disease treatment.
    [Ceapro, Inc.]

    Press Release

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    FEATURED EVENT

    EMBO Workshop: Cancer Immunometabolism

    November 29 – December 1, 2021
    Barcelona, Spain
    JOB OPPORTUNITIES

    Postdoctoral Research Fellow – Cardiac and Endothelial Cell Function

    Stanford University – La Jolla, California, United States

    Research Associate – Neuromusculoskelatal Trauma and Tissue Regeneration

    The Geneva Foundation – Tacoma, Washington, United States

    Postdoctoral Fellow – Molecular Cell Biology

    University of Luxembourg – Luxembourg City, Luxembourg

    Faculty Position – Cancer Biology and Signal Transduction

    Purdue University – West Lafayette, Indiana, United States

    Research Associate – Cell and Regenerative Biology

    University Of Wisconsin–Madison – Madison, Wisconsin, United States

    > See All Jobs

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