| Vol. 6.29 – 23 August, 2021 |
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| High-density lipoproteins were isolated from plasma of wild-type mice, Apom knockout mice, human apoM transgenic mice or humans and radioiodinated to trace its binding, association, and transport by bovine or human aortic endothelial cells. [Arteriosclerosis, Thrombosis, and Vascular Biology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Despite endothelial cell insulin and insulin like growth factor-1 (IGF-1) resistance, mutant IGF-1R endothelial cell over-expressing mice had enhanced insulin and IGF-1 mediated systemic glucose disposal, lower fasting free fatty acids and triglycerides. [Circulation Research] |
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| Scientists demonstrated that IL-8 was upregulated by the fibroblast growth factor 2 (FGF2)-mediated priming effect during FECS-Ad formation. Immobilized FGF2 substrate induced stronger IL-8 expression than soluble FGF2 ligands, presumably through the FGFR1/JNK/NF-κB signaling cascade. [npj Regenerative Medicine] |
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| Using a proteomic approach, investigators analyzed the protein content of plasma extracellular vesicles and identified critical activated pathways in human umbilical vein endothelial cells and human progenitor hematopoietic cells. [Cell Death & Disease] |
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| The authors investigated the effects of silencing salusin-β on endothelial function, cardiac function, vascular and myocardial remodeling, and its underlying signaling pathways in chronic heart failure rats induced by coronary artery ligation. [Oxidative Medicine and Cellular Longevity] |
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| Investgiators employed an analysis pipeline consisting of molecular modeling and simulation, surface plasmon resonance spectrometry, biochemical assays, and endothelial cell models to demonstrate that UniPR1331 directly interacted with theVEGF receptor 2. [Cancer Gene Therapy] |
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| HCEC-12 cells were cultured in different concentrations of Coenzyme Q10 (CoQ10) and analyzed using live/dead staining assay to determine appropriate concentration for subsequent experiments. [American Journal of Ophthalmology] |
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| The molecular mechanism by which hyperoxia injures pulmonary capillary endothelial cells has not been fully elucidated. Scientists systematically investigated these issues using next-generation sequencing and functional research techniques by focusing on non-coding RNAs. [Scientific Reports] |
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| The proliferative, migratory, and angiogenic abilities of HUVECs were enhanced after exposure to exosomes derived from hepatocellular carcionoma cells by transmitting small nucleolar RNA host gene 16 (SNHG16). SNHG16 was validated to promote the biological function of HUVECs directly. [Journal of Physiology and Biochemistry] |
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| Researchers analyzed the permissiveness of primary endothelial cells of the human pulmonary microvasculature and of primary human epithelial cells derived from bronchi, bronchioles and alveoli for Old World orthohantavirus Puumala virus in vitro. [Virology Journal] |
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| The authors delve into the mechanisms behind anti-tumor immunity and seeks to identify the differential effect of dosing regimens, including daily low-dose and medium-dose intermittent chemotherapy, on both innate and adaptive immune populations involved in observed anti-tumor immune response. [Advanced Drug Delivery Reviews] |
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| Scientists summarize the current knowledge about statins and other agents used as endothelial protectants. They propose further studies using statins for prophylaxis and prevention of end-organ damage related to extensive endothelial dysfunction in hematopoietic stem cell transplantation and chimeric antigen receptor-T cells. [Blood Reviews] |
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| Ceapro, Inc. announced it has established a formal research collaboration with the Boston-based Angiogenesis Foundation, a prestigious independent scientific organization focused on driving innovations in health promotion, disease prevention, and disease treatment. [Ceapro, Inc.] |
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| November 29 – December 1, 2021 Barcelona, Spain |
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| Stanford University – La Jolla, California, United States |
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| The Geneva Foundation – Tacoma, Washington, United States |
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| University of Luxembourg – Luxembourg City, Luxembourg |
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| Purdue University – West Lafayette, Indiana, United States |
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| University Of Wisconsin–Madison – Madison, Wisconsin, United States |
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