Endothelial Cell News Volume 6.32 | Sep 20 2021

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    2021-09-20 | ENDOCN 6.32


    Endothelial Cell News by STEMCELL Technologies
    Vol. 6.32 – 20 September, 2021
    TOP STORY

    Chemerin Regulates Normal Angiogenesis and Hypoxia-Driven Neovascularization

    Chemerin did not affect vascular sprouting during the post-natal development of the network, but rather promoted endothelial cell apoptosis and vessel pruning.
    [Angiogenesis]

    Full Article

    Are Your Pluripotent Stem Cells What You Think They Are? Explore Now.
    PUBLICATIONSRanked by the impact factor of the journal

    CXCL13/CXCR5 Axis Facilitates Endothelial Progenitor Cell Homing and Angiogenesis during Rheumatoid Arthritis Progression

    Rheumatoid arthritis synovial fluid increased endothelial progenitor cell homing and angiogenesis, which was blocked by the CXCL13 antibody.
    [Cell Death & Disease]

    Full Article

    Bioglass Promotes Wound Healing by Inhibiting Endothelial Cell Pyroptosis through Regulation of the Connexin 43/Reactive Oxygen Species (ROS) Signaling Pathway

    Researchers investigated the possible effect of bioactive glass (BG) on pyroptosis in wound healing both in vivo and in vitro and showed that BG could accelerate wound closure, granulation formation, collagen deposition, and angiogenesis.
    [Laboratory Investigation]

    Abstract

    Targeting Integrin αvβ3 by a Rationally Designed Protein for Chronic Liver Disease Treatment

    The authors reported a strategy for chronic liver disease treatment by induction of integrin αvβ3 mediated cell apoptosis using a rationally designed protein (ProAgio). ProAgio was designed to target integrin αvβ3 at a novel site, which was highly expressed in activated hepatic stellate cells, angiogenic endothelium, and capillarized liver sinusoidal endothelial cells.
    [Communications Biology]

    Full Article

    Cellular Heterogeneity and Immune Microenvironment Revealed by Single-Cell Transcriptome in Venous Malformation and Cavernous Venous Malformation

    Investigators performed single-cell profiling of 35,245 cells from two venous malformation samples and three cavernous venous malformation samples, with a focus on endothelial cells, smooth muscle cells and immune microenvironment.
    [Journal of Molecular and Cellular Cardiology]

    AbstractGraphical Abstract

    Gamma Irradiation Exposure for Collapsed Cell Junctions and Reduced Angiogenesis of 3D In Vitro Blood Vessels

    The authors previously remodeled the ECM hydrogel that enhanced the tight barrier formation of 3D blood vessels and the vascular endothelial growth factor gradient induced angiogenesis in a microfluidic device. In this study, the blood vessel model was further introduced to understand how gamma irradiation affected the endothelial monolayer.
    [Scientific Reports]

    Full Article

    Pro-Angiogenic Effect of PC-3 Exosomes in Endothelial Cells In Vitro

    HUVEC cells treated with prostate cancer (PC)-3 exosomes showed increased invasion and tube formation ability.
    [Cellular Signalling]

    AbstractGraphical Abstract

    Paraquat-Induced Cholesterol Biosynthesis Proteins Dysregulation in Human Brain Microvascular Endothelial Cells

    Researchers unraveled biological mechanisms associated to the exposure of 1, 10 and 100 µM of paraquat for 24 hours on human brain microvascular endothelial cells.
    [Scientific Reports]

    Full Article

    Free E-Book: Genome Editing Applications for Disease Modeling and Cell Therapy.
    REVIEWS

    Angiogenesis Induction in Breast Cancer: A Paracrine Paradigm

    The authors provide an overview of the key growth factors that trigger breast cancer angiogenesis.
    [Cell Biochemistry and Function]

    Abstract

    Clinical Features, Pathophysiology and Therapy of Poor Graft Function Post Allogeneic Stem Cell Transplantation

    The pathophysiology of poor graft function can be conceptualized as dysfunction related to the number or productivity of the stem cell compartment, defects in bone marrow microenvironment components such as mesenchymal stromal cells and endothelial cells, or immunological suppression of post allogeneic stem cell transplant hematopoiesis.
    [Blood Advances]

    Abstract

    INDUSTRY AND POLICY NEWS

    AB Science Announced Today That It Has Received Authorization to Resume Patient Enrollment in the Phase II Masitinib Study of COVID-19 (AB20001)

    AB Science SA announced that it has received authorization from the Russian Health Ministry to resume patient enrollment in the phase II masitinib study of COVID-19.
    [AB Science (GlobeNewsWire, Inc.)]

    Press Release

    FEATURED EVENT

    AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics

    October 7 – 11, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Research Fellow – Cardiovascular Research

    Queen’s University Belfast – Belfast, Ireland

    Research Associate – Organogenesis, Stem Cells, and Regenerative Medicine

    University of Southern California – Los Angeles, California, United States

    PhD Studentship – Lung Metastatic Niche

    CRUK Beatson Institute for Cancer Research – Glasgow, Scotland, United Kingdom

    Postdoctoral Associate – Cardiovascular Biology and Disease Modeling

    Sanford Burnham Prebys Medical Discovery Institute – San Diego, California, United States

    Postdoctoral Research Fellow – Cardiac and Endothelial Cell Function

    Stanford University – La Jolla, California, United States

    > See All Jobs

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