 | | | Vol. 6.39 – 15 November, 2021 |
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| The authors demonstrated that a high-sucrose diet during adolescence induced psychosis-related behavioral endophenotypes, including hyperactivity, poor working memory, impaired sensory gating, and disrupted interneuron function in mice deficient for glyoxalase-1.
[Science Advances] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed that the supernatant from ubiquitin-specific protease 12 (USP12)-overexpressing breast cancer cells could promote angiogenesis according to HUVEC migration and tube formation assays.
[Cell Death & Disease] |
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| By exposing bEnd.3 endothelial cells and primary cortical neurons to oxygen−glucose deprivation (OGD), the impact of extracellular vesicles from OGD-preconditioned microglia on angiogenesis and neuronal apoptosis by the tube formation assay and TUNEL staining was assessed.
[Cell Death & Disease] |
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| Treatment of endothelial cells with insulin did not affect endothelial fatty acid uptake, but endothelial cells took up more fatty acids when exposed to media conditioned by adipocytes treated with insulin.
[Journal of Cell Science] |
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| Scientists developed an approach to examine endothelial RNA expression by using an endothelial-specific marker to isolate nuclei from abundant archived frozen brain tissues.
[Laboratory Investigation] |
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| Researchers suggested that angiogenesis promoted beta-cell survival in the inflamed pancreas, while suppression of angiogenesis turned beta-cell epithelial–mesenchymal transition into apoptotic beta-cell death.
[Laboratory Investigation] |
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| In human dermal microvascular endothelial cells, FLI1 siRNA induced the expression of CCR6, but not CCL20, and FLI1 bound to the CCR6 promoter.
[Arthritis Research & Therapy] |
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| To examine the interaction between trabecular meshwork cells on Schlemm’s canal endothelial cells, the authors investigated whether exosomes contributed to intercellular communication.
[Scientific Reports] |
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| Scientists investigated the effect of icariin on endothelial microparticles, endothelial progenitor cells, platelets, and erectile function in spontaneously hypertensive rats.
[andrology] |
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| Investigators explored the potential role and mechanism of circ_0057583 in brain microvascular endothelial cell injury. Human brain microvascular endothelial cells were exposed to different doses of lipopolysaccharide to induce cell damage.
[Metabolic Brain Disease] |
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| Researchers explored the role and molecular mechanisms underlying Netrin‑1 in the viability and angiogenic function of endothelial progenitor cells (EPCs). The apoptosis and various functions of EPCs were analyzed in vitro by manipulating the expression of Netrin‑1.
[Molecular Medicine Reports] |
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| The authors describe the interactive roles of the renin–angiotensin system, the complement system, and the closely linked kallikrein–kinin and contact systems in cell biological functions such as vascular tone and leakage, inflammation, chemotaxis, thrombosis and cell proliferation.
[Nature Reviews Immunology] |
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| Investigators highlight efforts to develop imaging techniques and to therapeutically manipulate macrophages in atherosclerotic plaques with the use of rationally designed nanoparticles, and review the latest progress in nanoparticle-based imaging modalities that can specifically target macrophages.
[Nature Reviews Cardiology] |
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| Scientists suggest that careful assessment of the status of converted cells using genetic and epigenetic profiling, various functional assays, and the use of multiple readouts is essential to determine successful conversion.
[Circulation Journal] |
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| Oxurion NV announced that the first patient has been dosed in Part B of its two-part, Phase II study evaluating multiple injections of THR-149 for the treatment of DME. THR-149 is being developed to become the treatment of choice for DME patients who respond suboptimally to anti-VEGF therapy.
[Oxurion NV] |
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| December 8 – 9, 2021
Virtual |
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| | Sidney Kimmel Cancer Center – Philadelphia, Pennsylvania, United States |
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| University of California Los Angeles – Los Angeles, California, United States |
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| | The University of Sheffield – Sheffield, England, United Kingdom |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | Columbia University – New York, New York, United States |
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