 | | Vol. 6.41 – 29 November, 2021 |
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| Researchers discovered that angiogenesis following ischemic muscle injury in mice was not driven by endothelial sprouting, and revealed the emergence of wide-caliber, primordial conduits with an ultralow flow that rapidly transformed into a hierarchical neocirculation.
[Science Advances] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that bone marrow sinusoidal endothelial cells (BM-SEC) actively controlled erythropoiesis. While activation of Wnt-signaling in BM-SEC caused an increase in erythroblast subsets, mature erythroid cells were reduced, indicating impairment of terminal erythroid differentiation/reticulocyte maturation.
[Nature Communications] |
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| The authors demonstrated that vitexin, a natural flavonoid, could inhibit the activation of apurinic/apyrimidinic endonuclease1 (APEX1) to protect vascular endothelium against the adverse effects of atherogenic stimuli.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators revealed that IκB kinase (IKK)-α in distinct endothelial cell (EC)-derived compartments was uniquely required to promote B cell homeostasis and lymph node (LN) development, and they established that lymphatic EC-intrinsic IKK-α was absolutely essential for LN formation.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers investigated the effects of bone morphogenetic protein 9 on osteogenesis and angiogenesis of human amniotic mesenchymal stem cells cocultured with HUVECs and determined the possible underlying molecular mechanism.
[Aging] |
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| Investigators modeled the relationship of adipocytes and endothelial cells in vitro to test the role of insulin in fatty acid transport.
[Journal of Cell Science] |
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| Scientists cloned VEGF-B isoforms with different receptor binding profiles to clarify the roles of VEGFR-1 and Nrp-1 in angiogenesis and to see if angiogenic properties could be maintained while avoiding side effects.
[iScience] |
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| The authors investigated receptor-interacting protein 3 kinase, a key signaling molecule of programmed cell death, in UVA-induced injury using a short-term corneal endothelium culture model.
[Cell Death Discovery] |
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| Researchers identified that ribosomal protein L32 pseudogene 3 (RPL32P3) was highly expressed in glioma-exposed endothelial cells. Knockdown of RPL32P3 decreased the expression of tight junction-related proteins and increased blood–tumor barrier permeability.
[Cell Death Discovery] |
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| Scientists explored a novel strategy leveraging endothelial cell plasticity to enhance reprogramming efficiency. Rat cardiac endothelial cells and fibroblasts were treated with Gata4, Mef2c, and Tbx5 to assess the cardio-differentiation potential of these cells.
[Scientific Reports] |
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| The binding of IsdB and adhesion of Staphylococcus aureus expressing IsdB to monolayers of activated endothelial cells was significantly inhibited by a monoclonal antibody against the A1 domain and by IsdB reactive IgG from patients with staphylococcal endocarditis.
[Scientific Reports] |
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| Investigators evaluated endothelial glycocalyx barrier properties and microvascular perfusion in psoriatic patients, as well as their correlation with carotid intima-media thickness and markers of left ventricular myocardial deformation.
[Journal of Human Hypertension] |
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| Scientists found that small extracellular vesicles derived from metastatic melanoma cell lines were enriched in nerve growth factor receptor, spread through the lymphatic system and were taken up by lymphatic endothelial cells, reinforcing lymph node metastasis.
[Nature Cancer] |
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| VEGF is a potent angiogenic factor that may have a role in the pathogenesis of the Kaposi sarcoma herpesvirus (KSHV)-negative idiopathic form of multicentric Castelman disease (MCD) and KSHV-MCD, as endothelial cell and blood vessel proliferation is an important component of MCD.
[Nature Reviews Disease Primers] |
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| The authors provide a summary on the regulation and function of SIRT1 in the vascular endothelium and discuss the different approaches targeting this molecule for the prevention and treatment of age-related cardiovascular and cerebrovascular diseases.
[Journal of Cardiovascular Pharmacology] |
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| Merck and Eisai announced that the European Commission has approved the combination of KEYTRUDA, Merck’s anti-PD-1 therapy, plus LENVIMA for the treatment of advanced or recurrent endometrial carcinoma in adults who have disease progression on or following prior treatment with a platinum‑containing therapy.
[Merck] |
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| Calroy Health Sciences announced it has been awarded a patent titled “Methods to Stabilize and Reverse Atherosclerotic Lesions by Sulfated Polysaccharides” for its cardiovascular support product Arterosil®, a dietary supplement clinically proven to protect and restore the endothelial glycocalyx.
[Calroy Health Sciences (Business Wire, Inc.)] |
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| January 21 -23, 2022
Austin, Texas, United States |
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| | Stanford University – Palo Alto, California, United States |
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| | Accession Therapeutics – Oxford, England, United Kingdom |
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| | University of California Los Angeles – Los Angeles, California, United States |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | Columbia University – New York, New York, United States |
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