Endothelial Cell News Volume 6.43 | Dec 13 2021

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    2021-12-13 | ENDOCN 6.43


    Endothelial Cell News by STEMCELL Technologies
    Vol. 6.43 – 13 December, 2021
    TOP STORY

    Alveolar, Endothelial, and Organ Injury Marker Dynamics in Severe COVID-19

    Alveolar and endothelial injury may be differentially associated with COVID-19 disease severity over time. Scientists described alveolar and endothelial injury dynamics and associations with COVID-19 severity, cardiorenovascular injury, and outcomes.
    [American Journal of Respiratory and Critical Care Medicine]

    Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Endothelial Dysfunction Contributes to Severe COVID-19 in Combination with Dysregulated Lymphocyte Responses and Cytokine Networks

    The authors combined analyses of immune cells and cytokine/chemokine networks with endothelial activation and injury.
    [Signal Transduction and Targeted Therapy]

    Full Article

    Proteomic Profiling of MIS-C Patients Indicates Heterogeneity Relating to Interferon Gamma Dysregulation and Vascular Endothelial Dysfunction

    Scientists performd a comprehensive analysis of the plasma proteome of more than 1400 proteins in children with SARS-CoV-2. They showed that protein signatures demonstrated overlap between multi-system inflammatory syndrome in children, and the inflammatory syndromes macrophage activation syndrome and thrombotic microangiopathy.
    [Nature Communications]

    Full Article

    aPC/PAR1 Confers Endothelial Anti-Apoptotic Activity via a Discrete, β-Arrestin-2–Mediated SphK1-S1PR1-Akt Signaling Axis

    Using human cultured endothelial cells, researchers found that endogenous protease-activated receptor-1 (PAR1) and sphingosine-1-phosphate receptor-1 (S1PR1) coexisted in caveolin-1–rich microdomains and that S1PR1 co-association with Cav1 was increased by activated protein C (aPC) activation of PAR1.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    STAT3-YAP/TAZ Signaling in Endothelial Cells Promotes Tumor Angiogenesis

    Scientists studied the role of YAP/TAZ signaling in endothelial cells (ECs) in tumor angiogenesis and found that the expression of YAP/TAZ and downstream target genes in ECs correlated with tumor vascularization in human colorectal carcinomas and skin melanoma.
    [Science Signaling]

    Full Article

    MiR-29cb2 Promotes Angiogenesis and Osteogenesis by Inhibiting Hif-3α in Bone

    The authors showed that miR-29cb2 was a bone-specific miRNA and played critical roles on angiogenesis-osteogenesis coupling during bone remodeling.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    MiRNA-132/212 Regulates Tight Junction Stabilization in Blood–Brain Barrier after Stroke

    A co-culture of endothelial cells with CRTC1-deficient neurons aggravated the cell vulnerability to hypoxia, supporting the idea that miRNA-132/212 cluster was regulated by CRTC1 and acted as a crucial role in the mitigation of ischemic damage.
    [Cell Death Discovery]

    Full Article

    Impact of Macular Fluid Features on Outcomes of Anti-Vascular Endothelial Growth Factor Treatment for Type 3 Macular Neovascularization

    Investigators evaluated the impact of macular fluid features on visual and anatomical outcomes in type 3 macular neovascularization (MNV) patients treated with anti-VEGF. They found that the macular fluid morphology in type 3 MNV showed no significant correlation with visual and anatomical outcomes.
    [Scientific Reports]

    Full Article

    The Role of Calcium Oscillations in the Phenotype Selection in Endothelial Cells

    Scientists developed a model based on two previously published and experimentally validated mathematical models of calcium and angiogenesis and used resulting models to simulate various multi-cell scenarios.
    [Scientific Reports]

    Full Article

    Improvement of Tube Formation Model of Cell: Application for Acute Hypoxia in In Vitro Study of Angiogenesis

    Investigators found that sodium dithionite induced endothelial cell tube formation without matrigel under hypoxia conditions. The angiogenesis related proteins and mRNA at different time points after tube formation were measured both in primary HUVECs and murine microvascular endothelial cell lines.
    [Microvascular Research]

    AbstractGraphical Abstract
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    REVIEWS

    A Novel Personalized Treatment Approach for Psoriasis: Anti-VEGF-A Therapy

    Vascular endothelial growth factor A (VEGF-A) mediates angiogenesis and is upregulated in the plaques and plasma of patients with psoriasis. Targeting VEGF-A in in vivo models of psoriasis-like inflammation results in disease clearance.
    [British Journal of Dermatology]

    Abstract
    INDUSTRY AND POLICY NEWS

    SynDevRx Announces Research Collaboration with Queensland University of Technology (QUT) to Study the Effects of SDX-7320 In Advanced Prostate Cancer Models

    SynDevRx, Inc. announced a research collaboration with Australia’s Queensland University of Technology. The collaboration with Professor Colleen Nelson, PhD, and her team will study the role of methionine aminopeptidase 2 inhibition in tumor growth in castration resistant and other treatment resistant forms of prostate cancer.
    [SynDevRx, Inc.]

    Press Release
    FEATURED EVENT

    Lorne Cancer 2022

    February 10 – 12, 2022
    Lorne, Victoria, Australia

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Student – Cardiovascular Research

    Karolinska Institute – Solna, Sweden

    Postdoctoral Fellows – Hypertension and Cardiorenal Diseases

    University of Mississippi Medical Center – Jackson, Mississippi, United States

    Faculty Positions – Pediatric Hematology, Oncology, Stem Cell Transplantation & Regenerative Medicine

    Stanford University – Palo Alto, California, United States

    Researcher – Cell Biologist

    Accession Therapeutics – Oxford, England, United Kingdom

    Postdoctoral Researcher – Endothelial Cell Migration

    University of California Los Angeles – Los Angeles, California, United States

    > See All Jobs

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