 | | Vol. 7.05 – 14 February, 2022 |
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| Researchers investigated the role of valvular endothelial cell-derived tetrahydrobiopterin in aortic valve calcification.
[European Heart Journal] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists observed that endothelial colony forming cells derived from patients with low Von Willebrand Factor (VWF) demonstrated alterations in baseline Weibel Palade body metrics and exhibited impaired VWF release.
[Blood] |
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| Researchers described the identification of vimentin, an intermediate filament protein widely expressed in cells of mesenchymal origin, as an important attachment factor for SARS-CoV-2 on human endothelial cells.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists evaluated the global mapping of VEGF-mediated dynamic transcriptional events, focusing on major histone-code profiles using chromatin immunoprecipitation sequencing.
[Cell Reports] |
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| Phenazine biosynthesis-like domain-containing protein (PBLD) exerted an inhibitory effect on angiogenesis not only via blocking the VEGFR2 expression in endothelial cells, but also through downregulating HIF-1a-induced VEGF expression and secretion in hepatocellular carcinoma (HCC) cells.
[Oncogene] |
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| CircKDM4B inhibited migration and tube formation of HUVECs in vitro and angiogenesis in vivo.
[Oncogene] |
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| Investigators provided a systematic metabolic comparison of endothelial cells derived from chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension patients.
[Scientific Reports] |
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| Using cultured HUVECs, scientists looked for sites of extracellular vesicle release using ultra-rapid freezing, freeze substitution, and serial section electron microscopy.
[Biophysical Journal] |
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| Transient receptor potential vanilloid 4 (TRPV4) enabled endothelial cells, smooth muscle cells, and perivascular neurons, to integrate hemodynamic forces to regulate systemic blood pressure.
[Biophysical Journal] |
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Researchers assessed the suppressing effect of VGB4, a VEGF antagonist peptide with the binding ability to both VEGF receptor1 and VEGF receptor2, on VEGF-induced proliferation and migration of the human lung adenocarcinoma cell line A549 and the human colon adenocarcinoma cell line HT29.
[Molecular Biology Reports] |
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| Scientists characterize the physiology of endothelial small conductance channels in the microvasculature under normal and pathological conditions.
[European Journal of Cell Biology] |
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| The authors discuss the process of protein tyrosine nitration, increased expression of nitrated proteins in cardiovascular disease and their association with endothelial dysfunction, the interference of tyrosine nitration with antioxidants and the protective role in endothelial dysfunction.
[Clinica Chimica Acta] |
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| IVERIC Bio, Inc. announced a post-hoc analysis which evaluated various Geographic Atrophy (GA) growth parameters to explore the rate of disease progression within various regions in the fovea in a subset of patients from the GATHER1 Zimura® Phase III clinical trial for the treatment of GA.
[IVERIC Bio, Inc.] |
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| April 7 – April 9
Rome, Italy & Virtual |
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| | The University of Tennessee Health Science Center – Memphis, Tennessee, United States |
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| Yale University – New Haven, Connecticut, United States |
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| Helmholtz Centre for Infection Research – Braunschweig, Germany |
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| | Columbia University – New York, New York, United States |
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| | Ksilink – Strasbourg, France |
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