 | | Vol. 7.11 – 4 April, 2022 |
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| Scientists demonstrated that cutaneous vaccinia virus infection by scarification activated dermal lymphatic capillary junction tightening and lymph node lymphangiogenesis, which were associated with reduced fluid transport and cutaneous viral sequestration.
[Journal of Experimental Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers developed endothelial cell-laden pro- and anti-angiogenic bioinks, supplemented with bioactive matrix-derived microfibers that were created from type I collagen sponges and cartilage decellularized ECM.
[Biofabrication] |
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| Scientists developed an integrated approach is developed to characterize the anisotropic elasticity of the endothelium under physiological-level fluid shear stress.
[Acta Biomaterialia] |
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| Researchers investigated the role of the endoplasmic reticulum-anchored protein, Protrudin, in endothelial cell protrusion, migration and angiogenesis.
[Cellular and Molecular Life Sciences] |
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| With transgenic mice that expressed a dominant-negative mutant of the pore-forming Kir6.1 subunit specifically in brain capillary endothelial cells or pericytes, scientists demonstrated that ATP-sensitive K+ channels were present in both cell types and robustly controlled membrane potential.
[Science Signaling] |
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| Scientists investigated the important role and mechanism of C3a in preventing the occurrence of pyroptosis to protect the lung endothelial cells in sepsis-induced acute lung injury.
[Free Radical Biology and Medicine] |
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| Researchers searched for differentially expressed circRNAs in old endothelial cells (OECs) and young endothelial cells by circRNA sequencing and found that circGSE1 was significantly downregulated in OECs.
[Aging-Us] |
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| The authors constructed hydrogel substrates with the stiffness of 18–86 kPa to explore the effect of physiological stiffness on vascular cells.
[Colloids and Surfaces B-Biointerfaces] |
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| Investigators showed that endothelial-induced astrocytes had upregulated expression of A1 astrocytic genes and exhibited a distinctive ECM remodeling profile.
[Communications Biology] |
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| The authors provide an update on the role of endothelial progenitor cells in the most common clinical scenarios that are experienced by cardiologists managing patients with coronary artery disease.
[Stem Cells Translational Medicine] |
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| Scientists review existing strategies for fabricating and incorporating vascular elements and perfusion within tissue organoids.
[Mammalian Genome] |
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| Outlook Therapeutics, Inc. announced it has submitted its Biologics License Application to the FDA for ONS-5010, an investigational therapy which, if approved, will be branded as LYTENAVA™, for the treatment of wet age-related macular degeneration.
[Outlook Therapeutics, Inc.] |
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| May 25-29, 2022
Lyon, France |
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| University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| Babraham Institute – Cambridgeshire, England, United Kingdom |
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| | Thorax Institute – Nantes, France |
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