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Vol. 7.39 – 14 November, 2022
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Investigators introduced an anticancer drug delivery concept termed Flash Release in Endothelium (FlaRE), which represented an alternative to the existing approaches based on enhanced permeability and retention effect.
[Nature Communications]
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PUBLICATIONSRanked by the impact factor of the journal
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Using comparative genome-wide endothelial cell-pericyte crosstalk analysis of healthy and LPS-challenged lungs, scientists discovered that crosstalk between endothelial nitric oxide and pericyte soluble guanylate cyclase (NO-sGC) was impaired in acute lung injury.
[Journal of Experimental Medicine]
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The authors reported that tumor cell-derived adrenomedullin had a pro-angiogenic as well as a direct tumor-promoting effect, and that endothelium-derived CC chemokine ligand 2 (CCL2) suppressed adrenomedullin-induced tumor cell proliferation.
[Journal of Experimental Medicine]
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Researchers studied the effect of aging on arterial DNA damage and telomere dysfunction. Aging resulted in greater DNA damage in endothelial cells than in vascular smooth muscle cells.
[GeroScience]
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Using transgenic mice expressing either constitutively edited or constitutively uneditable Filamin A, scientists showed that Filamin A editing critically controled angiogenesis in tumors as well as in a mouse ischemia model.
[Molecular Therapy-Nucleic Acids]
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Plasma levels of surfactant protein-D, soluble receptor for advanced glycation end products, and angiopoietin-2 were measured in a prospective, multicenter cohort of invasively ventilated patients.
[American Journal of Physiology-Lung Cellular and Molecular Physiology]
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Investigators reported on the novel stent endothelialization strategy of post-deployment seeding of biotin-modified endothelial cells to avidin-functionalized stents.
[Scientific Reports]
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Scientists investigated the restorative and protective potentials of paricalcitol, a vitamin D analog, which was frequently used in patients with chronic renal failure in HUVECs before and after hydrogen peroxide-induced oxidative stress.
[Experimental Biology and Medicine]
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Corneal endothelium parameters including endothelial cell density, average cell size, coefficient of variation in cell size, and hexagonality were evaluated by non-contact specular microscopy.
[BMC Ophthalmology]
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The authors review the impact of anti-VEGF treatment in the management of eyes with non-proliferative diabetic retinopathy without center involving diabetic macular edema.
[Eye]
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Contego Medical, Inc. announced that enrollment of the PERFORMANCE II clinical trial had been completed. PERFORMANCE II was designed to evaluate the safety and effectiveness of the Neuroguard IEP® 3-in-1 carotid stent and post-dilation balloon system with integrated embolic protection.
[Contego Medical, Inc.]
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March 6 – 8, 2023
Paris, France
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Boston University – Boston, Massachusetts, United States
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Imperial College London – London, England, United Kingdom
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Yale University – New Haven, Connecticut, United States
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Lifespan – Providence, Rhode Island, United States
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Washington University School of Medicine – Saint Louis, Missouri, United States
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