ESC & iPSC News Volume 10.40 | Oct 21 2015

Myeloid Dysregulation in a Human Induced Pluripotent Stem Cell Model of PTPN11-Associated Juvenile Myelomonocytic Leukemia
Researchers report that hematopoietic cells differentiated from human induced pluripotent stem cells harboring Noonan syndrome/juvenile myelomonocytic leukemia (JMML)-causing PTPN11 mutations recapitulated JMML features. [Cell Rep] Full Article | Graphical Abstract | Press Release

Glycolipid Dynamics in Generation and Differentiation of Induced Pluripotent Stem Cells
The authors defined the dynamics of glycosphingolipid remodeling during reprogramming from parental cell sets to induced pluripotent stem cell (iPSC) sets and thence to iPSC-neural cells. [Sci Rep] Full Article

Derivation of Ethnically Diverse Human Induced Pluripotent Stem Cell Lines
Investigators derived xenofree ethnically diverse-human induced pluripotent stem cell lines from fibroblasts obtained from individuals of African American, Hispanic-Latino, Asian, and Caucasian ethnic origin and characterized the lines under a uniform platform for comparative analysis. [Sci Rep] Full Article

Progressive Chromatin Condensation and H3K9 Methylation Regulate the Differentiation of Embryonic and Hematopoietic Stem Cells
Using nuclease sensitivity assays, scientists found a progressive decrease in chromatin digestion among pluripotent embryonic stem cells, multipotent hematopoietic stem cells, and mature hematopoietic cells. [Stem Cell Rep] Full Article | Graphical Abstract

An Orthologous Epigenetic Gene Expression Signature Derived from Differentiating Embryonic Stem Cells Identifies Regulators of Cardiogenesis
Scientists used predictive gene expression signatures within a multi-species framework to identify the genes that underlie cardiac cell fate decisions in differentiating embryonic stem cells. [PLoS One] Full Article

Differences in the Early Development of Human and Mouse Embryonic Stem Cells
Investigators performed a systematic analysis of gene expression features in early development of human vs mouse embryonic cells. Many development features were found to be conserved, and a majority of differentially regulated genes have similar expression change in both organisms. [PLoS One] Full Article

GSK3β Inhibition Activates the CDX/HOX Pathway and Promotes Hemogenic Endothelial Progenitor Differentiation from Human Pluripotent Stem Cells
Since hematopoietic and endothelial cells are derived from common progenitors, scientists examined the effect of transient GSK3β inhibitor treatment on hematopoietic cell differentiation from human induced pluripotent stem cells. [Exp Hematol] Abstract

Derivation of Induced Pluripotent Stem Cells from Orangutan Skin Fibroblasts
For potential species conservation and functional genomics studies, the authors derived induced pluripotent stem cells from cryopreserved somatic cells obtained from captive orangutans. [BMC Res Notes] Full Article

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German and US Partners Join Forces in Stem Cell Research to Accelerate Development of New Therapies
Researchers at The Scripps Research Institute and two German institutes, the Center for Integrated Psychiatry Kiel and the Fraunhofer Institute for Molecular Biology and Applied Ecology IME, have announced a partnership to advance the quality control of human stem cells. [The Scripps Research Institute] Press Release

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In Canada, Election Results Cheer Scientists
Many Canadian scientists are celebrating the result of Canada’s federal election, which saw Stephen Harper’s Conservative government defeated after nearly 10 years in power. [ScienceInsider] Editorial

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Research Technician – Basic Sciences/Cell and Molecular Biology (Fred Hutchinson Cancer Research Center)

Postdoctoral Position – Tissue Engineering and Regenerative Medicine (Northwestern University)

Postdoctoral Fellow – iPSC Research (Icahn School of Medicine at Mount Sinai)

Postdoctoral Position – Biomaterials for Cell Reprogramming (Institute of Tissue Regeneration Engineering)

Postdoctoral Position – Stem Cells, Development, and Cancer Biology (University of California, Santa Cruz)

Assistant/Associate/Full Professor – Biomedical Engineering (Worcester Polytechnic Institute)

Assistant Professor – Stem Cell Biology (University of South Carolina)

Postdoctoral Position – Spinal Cord Injury Research (Indiana University-Purdue University)

Postdoctoral Fellow – HMGA Chromatin Remodeling Proteins in Cancer and Stem Cell Biology (Johns Hopkins University School of Medicine)

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